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Merkley CM, Jian C, Mosa A, et al. Homeostatic regulation of adult hippocampal neurogenesis in aging rats: long-term effects of early exercise. Front Neurosci. 2014;8:174doi: 10.3389/fnins.2014.00174.
Merkley, C. M., Jian, C., Mosa, A., Tan, Y. F., & Wojtowicz, J. M. (2014). Homeostatic regulation of adult hippocampal neurogenesis in aging rats: long-term effects of early exercise. Frontiers in neuroscience, 8174. https://doi.org/10.3389/fnins.2014.00174
Merkley, Christina M, et al. "Homeostatic regulation of adult hippocampal neurogenesis in aging rats: long-term effects of early exercise." Frontiers in neuroscience vol. 8 (2014): 174. doi: https://doi.org/10.3389/fnins.2014.00174
Merkley CM, Jian C, Mosa A, Tan YF, Wojtowicz JM. Homeostatic regulation of adult hippocampal neurogenesis in aging rats: long-term effects of early exercise. Front Neurosci. 2014 Jul 01;8:174. doi: 10.3389/fnins.2014.00174. eCollection 2014. PMID: 25071426; PMCID: PMC4077125.
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Front Neurosci. 2014 Jul 01;8:174. doi: 10.3389/fnins.2014.00174. eCollection 2014.

Homeostatic regulation of adult hippocampal neurogenesis in aging rats: long-term effects of early exercise.

Frontiers in neuroscience

Christina M Merkley, Charles Jian, Adam Mosa, Yao-Fang Tan, J Martin Wojtowicz

Affiliations

  1. Department of Physiology, Faculty of Medicine, University of Toronto Toronto, ON, Canada.

PMID: 25071426 PMCID: PMC4077125 DOI: 10.3389/fnins.2014.00174

Abstract

Adult neurogenesis is highly responsive to environmental and physiological factors. The majority of studies to date have examined short-term consequences of enhancing or blocking neurogenesis but long-term changes remain less well understood. Current evidence for age-related declines in neurogenesis warrant further investigation into these long-term changes. In this report we address the hypothesis that early life experience, such as a period of voluntary running in juvenile rats, can alter properties of adult neurogenesis for the remainder of the animal's life. The results indicate that the number of proliferating and differentiating neuronal precursors is not altered in runners beyond the initial weeks post-running, suggesting homeostatic regulation of these processes. However, the rate of neuronal maturation and survival during a 4 week period after cell division was enhanced up to 11 months of age (the end of the study period). This study is the first to show that a transient period of physical activity at a young age promotes changes in neurogenesis that persist over the long-term, which is important for our understanding of the modulation of neurogenesis by exercise with age. Functional integration of adult-born neurons within the hippocampus that resist homeostatic regulation with aging, rather than the absolute number of adult-born neurons, may be an essential feature of adult neurogenesis that promotes the maintenance of neural plasticity in old age.

Keywords: adult neurogenesis; aging; dentate gyrus; exercise; hippocampus; homeostasis; plasticity

References

  1. Nat Protoc. 2006;1(3):1399-405 - PubMed
  2. Neurobiol Aging. 2006 Oct;27(10):1505-13 - PubMed
  3. Trends Neurosci. 1997 Nov;20(11):523-9 - PubMed
  4. Eur J Neurosci. 2008 Mar;27(6):1494-502 - PubMed
  5. J Neurosci. 2007 Mar 21;27(12):3252-9 - PubMed
  6. Front Hum Neurosci. 2012 Dec 12;6:327 - PubMed
  7. Ann Neurol. 2002 Aug;52(2):135-43 - PubMed
  8. Hippocampus. 2005;15(5):579-86 - PubMed
  9. Neuroscience. 2004;124(1):71-9 - PubMed
  10. Trends Cogn Sci. 2013 Oct;17(10):525-44 - PubMed
  11. J Neurophysiol. 2005 May;93(5):2406-14 - PubMed
  12. Hippocampus. 2009 Oct;19(10):1040-9 - PubMed
  13. Int J Mol Med. 2008 Oct;22(4):529-39 - PubMed
  14. Brain Res. 2004 Aug 13;1017(1-2):21-31 - PubMed
  15. J Neuroendocrinol. 2013 Nov;25(11):1039-61 - PubMed
  16. J Neurosci. 2000 Apr 15;20(8):2896-903 - PubMed
  17. Brain Res. 1996 Jul 8;726(1-2):49-56 - PubMed
  18. Mol Brain. 2010 Apr 28;3:13 - PubMed
  19. J Neurosci Res. 2004 May 1;76(3):356-62 - PubMed
  20. J Alzheimers Dis. 2011;24(3):421-54 - PubMed
  21. Nature. 1995 Jan 12;373(6510):109 - PubMed
  22. Neurobiol Dis. 2009 Sep;35(3):426-32 - PubMed
  23. Prog Brain Res. 2007;163:567-76 - PubMed
  24. J Neurosci. 2005 Apr 27;25(17):4217-21 - PubMed
  25. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2367-72 - PubMed
  26. Front Neurosci. 2013 Apr 04;7:50 - PubMed
  27. J Neurosci Res. 2010 Aug 1;88(10):2103-17 - PubMed
  28. Neuromolecular Med. 2008;10(2):128-40 - PubMed
  29. J Gerontol A Biol Sci Med Sci. 2008 Jan;63(1):62-6 - PubMed
  30. Genes Brain Behav. 2005 Mar;4(2):89-98 - PubMed
  31. Neuroscience. 2001;107(4):603-13 - PubMed
  32. J Comp Neurol. 2003 Dec 1;467(1):1-10 - PubMed
  33. Endocrinology. 1997 Aug;138(8):3515-20 - PubMed
  34. Dev Neurobiol. 2012 Jun;72(6):943-52 - PubMed
  35. Behav Brain Res. 2012 Feb 14;227(2):497-507 - PubMed
  36. Mol Cell Neurosci. 2010 Jan;43(1):127-35 - PubMed
  37. Neuron. 2011 May 26;70(4):589-96 - PubMed
  38. J Neurophysiol. 2001 Jun;85(6):2423-31 - PubMed
  39. Curr Alzheimer Res. 2012 Jul;9(6):621-7 - PubMed
  40. J Neurosci. 1996 Mar 15;16(6):2027-33 - PubMed
  41. Gerontologist. 1997 Apr;37(2):150-6 - PubMed
  42. Alzheimers Dement. 2009 Jul;5(4):287-94 - PubMed
  43. J Neurosci Methods. 2002 Mar 30;115(1):97-105 - PubMed
  44. Trends Neurosci. 2010 Dec;33(12):569-79 - PubMed
  45. J Int Neuropsychol Soc. 2002 Mar;8(3):448-60 - PubMed
  46. Neuron. 2007 May 24;54(4):559-66 - PubMed
  47. J Neurosci. 2012 Feb 29;32(9):3101-8 - PubMed
  48. Front Neurosci. 2013 Aug 20;7:145 - PubMed
  49. J Neurosci. 2013 Apr 10;33(15):6614-22 - PubMed
  50. Hippocampus. 2009 Oct;19(10):1019-29 - PubMed
  51. Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):5263-7 - PubMed
  52. Ann Neurol. 2013 Oct;74(4):611-21 - PubMed
  53. Cell. 2013 Jun 6;153(6):1219-1227 - PubMed
  54. Mol Neurodegener. 2011 Dec 22;6:85 - PubMed
  55. Neuroscience. 2005;133(3):853-61 - PubMed
  56. Nat Neurosci. 1999 Oct;2(10):894-7 - PubMed
  57. Trends Neurosci. 2008 Apr;31(4):163-9 - PubMed
  58. Neurobiol Learn Mem. 2008 Oct;90(3):511-8 - PubMed
  59. Science. 2003 Dec 5;302(5651):1760-5 - PubMed
  60. Physiol Rev. 2005 Apr;85(2):523-69 - PubMed
  61. Neuroreport. 1995 Dec 15;6(18):2479-82 - PubMed
  62. Curr Alzheimer Res. 2011 Nov;8(7):707-17 - PubMed
  63. Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20906-11 - PubMed
  64. J Appl Physiol (1985). 2008 Nov;105(5):1585-94 - PubMed
  65. Neurosci Lett. 2005 Sep 2;385(1):70-5 - PubMed
  66. Behav Brain Res. 2011 Apr 15;218(2):308-14 - PubMed
  67. Nature. 2011 Aug 31;477(7362):90-4 - PubMed
  68. Science. 2009 Jul 10;325(5937):210-3 - PubMed
  69. Nat Neurosci. 2007 Mar;10(3):355-62 - PubMed
  70. J Cell Physiol. 2000 Mar;182(3):311-22 - PubMed
  71. Brain Res Brain Res Rev. 1999 Nov;30(3):236-49 - PubMed
  72. Brain Behav Immun. 2012 Jul;26(5):803-10 - PubMed
  73. Brain Behav Immun. 2013 Feb;28:25-43 - PubMed
  74. J Neurosci. 2005 Sep 21;25(38):8680-5 - PubMed
  75. Neurobiol Aging. 1989 Jul-Aug;10(4):353-8 - PubMed
  76. Front Neurosci. 2010 Dec 08;4:189 - PubMed
  77. Eur J Neurosci. 1999 Apr;11(4):1479-85 - PubMed
  78. PLoS One. 2013 Sep 27;8(9):e76497 - PubMed
  79. Network. 2009;20(3):137-61 - PubMed
  80. Nature. 2011 Apr 28;472(7344):466-70 - PubMed
  81. Behav Brain Res. 2012 Feb 14;227(2):384-90 - PubMed
  82. Neuroscience. 2011 Sep 29;192:773-80 - PubMed
  83. Front Neurosci. 2011 Mar 21;5:34 - PubMed

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