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Manjili MH, Wang XY, Abrams S. Evolution of Our Understanding of Myeloid Regulatory Cells: From MDSCs to Mregs. Front Immunol. 2014;5:303doi: 10.3389/fimmu.2014.00303.
Manjili, M. H., Wang, X. Y., & Abrams, S. (2014). Evolution of Our Understanding of Myeloid Regulatory Cells: From MDSCs to Mregs. Frontiers in immunology, 5303. https://doi.org/10.3389/fimmu.2014.00303
Manjili, Masoud H, et al. "Evolution of Our Understanding of Myeloid Regulatory Cells: From MDSCs to Mregs." Frontiers in immunology vol. 5 (2014): 303. doi: https://doi.org/10.3389/fimmu.2014.00303
Manjili MH, Wang XY, Abrams S. Evolution of Our Understanding of Myeloid Regulatory Cells: From MDSCs to Mregs. Front Immunol. 2014 Jul 02;5:303. doi: 10.3389/fimmu.2014.00303. eCollection 2014. PMID: 25071764; PMCID: PMC4078244.
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Front Immunol. 2014 Jul 02;5:303. doi: 10.3389/fimmu.2014.00303. eCollection 2014.

Evolution of Our Understanding of Myeloid Regulatory Cells: From MDSCs to Mregs.

Frontiers in immunology

Masoud H Manjili, Xiang-Yang Wang, Scott Abrams

Affiliations

  1. Department of Microbiology and Immunology, Virginia Commonwealth University , Richmond, VA , USA ; Massey Cancer Center, Virginia Commonwealth University , Richmond, VA , USA.
  2. Massey Cancer Center, Virginia Commonwealth University , Richmond, VA , USA ; Department of Human and Molecular Genetics, Virginia Commonwealth University , Richmond, VA , USA.
  3. Roswell Park Cancer Institute , Buffalo, NY , USA.

PMID: 25071764 PMCID: PMC4078244 DOI: 10.3389/fimmu.2014.00303

Abstract

The term myeloid-derived suppressor cells (MDSCs) was first suggested in 2007 in order to reflect the origin and function of myeloid cells during immunosuppression in cancer and other pathologic conditions. Emerging evidence suggests that MDSCs suppress CTL and Th1 responses in malignant diseases while they regulate effective immune responses in parasitic and helminth infections as well as Th17 inflammatory response during autoimmune diseases. Based on these data, the term myeloid regulatory cells (Mregs) more accurately reflects their function and interactions with different cells of the immune system during diseased conditions. Here, we provide evidence on the multifaceted function of Mregs during diseased states.

Keywords: Leishmania; Nippostrongylus; helminths; immunotherapy of cancer; myeloid regulatory cells; myeloid-derived suppressor cells

References

  1. Parasite Immunol. 1998 May;20(5):241-7 - PubMed
  2. Cancer Res. 2006 Jan 15;66(2):1123-31 - PubMed
  3. Nat Med. 2007 Jul;13(7):828-35 - PubMed
  4. Cancer Discov. 2012 Aug;2(8):722-35 - PubMed
  5. Immunol Lett. 2005 Jun 15;99(1):17-23 - PubMed
  6. J Exp Med. 2013 Jul 1;210(7):1433-445 - PubMed
  7. Int Immunol. 2002 Oct;14(10):1125-34 - PubMed
  8. Blood. 2009 Apr 2;113(14):3190-7 - PubMed
  9. World J Gastroenterol. 2012 Oct 14;18(38):5454-61 - PubMed
  10. Immunity. 2008 Aug 15;29(2):306-17 - PubMed
  11. Cancer Cell. 2004 Oct;6(4):409-21 - PubMed
  12. Semin Cancer Biol. 2006 Feb;16(1):53-65 - PubMed
  13. J Immunol. 2009 Jan 1;182(1):240-9 - PubMed
  14. Clin Exp Immunol. 2009 Apr;156(1):17-24 - PubMed
  15. Eur J Immunol. 2014 Jan;44(1):184-94 - PubMed
  16. J Leukoc Biol. 2011 Dec;90(6):1191-7 - PubMed
  17. Blood. 2008 Apr 15;111(8):4233-44 - PubMed
  18. Cancer Immunol Immunother. 2009 Jun;58(6):941-53 - PubMed
  19. J Immunol. 2013 Apr 1;190(7):3783-97 - PubMed
  20. Brain. 2009 Sep;132(Pt 9):2487-500 - PubMed
  21. J Immunol. 2009 Jul 15;183(2):937-44 - PubMed
  22. Mol Clin Oncol. 2013 Jul;1(4):675-679 - PubMed
  23. Parasite Immunol. 2005 Oct-Nov;27(10-11):395-405 - PubMed
  24. Hepatology. 2009 Sep;50(3):799-807 - PubMed
  25. Eur J Immunol. 2010 Nov;40(11):2976-85 - PubMed
  26. Infect Immun. 2004 Jan;72(1):398-407 - PubMed
  27. Eur J Immunol. 2000 Apr;30(4):1127-35 - PubMed
  28. J Exp Med. 2005 Oct 3;202(7):931-9 - PubMed
  29. J Immunol. 2012 Jul 15;189(2):511-5 - PubMed
  30. J Immunol. 2012 Nov 1;189(9):4295-304 - PubMed
  31. Cancer Res. 2008 Jul 1;68(13):5439-49 - PubMed
  32. J Immunol. 2012 Aug 15;189(4):1843-9 - PubMed
  33. Infect Immun. 1996 Dec;64(12):4960-6 - PubMed
  34. Clin Cancer Res. 2012 Oct 1;18(19):5212-23 - PubMed
  35. Cancer Res. 2007 Jan 1;67(1):425; author reply 426 - PubMed
  36. J Leukoc Biol. 2014 Jul;96(1):151-9 - PubMed

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