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Hashimoto H, Matsuura T, Ueta Y. Fluorescent visualization of oxytocin in the hypothalamo-neurohypophysial system. Front Neurosci. 2014;8:213doi: 10.3389/fnins.2014.00213.
Hashimoto, H., Matsuura, T., & Ueta, Y. (2014). Fluorescent visualization of oxytocin in the hypothalamo-neurohypophysial system. Frontiers in neuroscience, 8213. https://doi.org/10.3389/fnins.2014.00213
Hashimoto, Hirofumi, et al. "Fluorescent visualization of oxytocin in the hypothalamo-neurohypophysial system." Frontiers in neuroscience vol. 8 (2014): 213. doi: https://doi.org/10.3389/fnins.2014.00213
Hashimoto H, Matsuura T, Ueta Y. Fluorescent visualization of oxytocin in the hypothalamo-neurohypophysial system. Front Neurosci. 2014 Jul 23;8:213. doi: 10.3389/fnins.2014.00213. eCollection 2014. PMID: 25100939; PMCID: PMC4107947.
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Front Neurosci. 2014 Jul 23;8:213. doi: 10.3389/fnins.2014.00213. eCollection 2014.

Fluorescent visualization of oxytocin in the hypothalamo-neurohypophysial system.

Frontiers in neuroscience

Hirofumi Hashimoto, Takanori Matsuura, Yoichi Ueta

Affiliations

  1. Department of Physiology, School of Medicine, University of Occupational and Environmental Health Kitakyushu, Japan.

PMID: 25100939 PMCID: PMC4107947 DOI: 10.3389/fnins.2014.00213

Abstract

Oxytocin (OXT) is well known for its ability to the milk ejection reflex and uterine contraction. It is also involved in several other behaviors, such as anti-nociception, anxiety, feeding, social recognition, and stress responses. OXT is synthesized in the magnocellular neurosecretory cells (MNCs) in the hypothalamic paraventricular (PVN) and the supraoptic nuclei (SON) that terminate their axons in the posterior pituitary (PP). We generated transgenic rats that express the OXT and fluorescent protein fusion gene in order to visualize OXT in the hypothalamo-neurohypophysial system (HNS). In these transgenic rats, fluorescent proteins were observed in the MNCs and axon terminals in the PP. This transgenic rat is a new tool to study the physiological role of OXT in the HNS.

Keywords: CCK; c-fos; double transgenic rat; mRFP1; paraventricular nucleus; posterior pituitary; supraoptic nucleus

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