Display options
Cite
Krengel U, Bousquet PA. Molecular recognition of gangliosides and their potential for cancer immunotherapies. Front Immunol. 2014;5:325doi: 10.3389/fimmu.2014.00325.
Krengel, U., & Bousquet, P. A. (2014). Molecular recognition of gangliosides and their potential for cancer immunotherapies. Frontiers in immunology, 5325. https://doi.org/10.3389/fimmu.2014.00325
Krengel, Ute, and Bousquet, Paula A. "Molecular recognition of gangliosides and their potential for cancer immunotherapies." Frontiers in immunology vol. 5 (2014): 325. doi: https://doi.org/10.3389/fimmu.2014.00325
Krengel U, Bousquet PA. Molecular recognition of gangliosides and their potential for cancer immunotherapies. Front Immunol. 2014 Jul 21;5:325. doi: 10.3389/fimmu.2014.00325. eCollection 2014. PMID: 25101077; PMCID: PMC4104838.
Copy Download .nbib Format: NLM
Share it on

Front Immunol. 2014 Jul 21;5:325. doi: 10.3389/fimmu.2014.00325. eCollection 2014.

Molecular recognition of gangliosides and their potential for cancer immunotherapies.

Frontiers in immunology

Ute Krengel, Paula A Bousquet

Affiliations

  1. Department of Chemistry, University of Oslo , Oslo , Norway.

PMID: 25101077 PMCID: PMC4104838 DOI: 10.3389/fimmu.2014.00325

Abstract

Gangliosides are sialic-acid-containing glycosphingolipids expressed on all vertebrate cells. They are primarily positioned in the plasma membrane with the ceramide part anchored in the membrane and the glycan part exposed on the surface of the cell. These lipids have highly diverse structures, not the least with respect to their carbohydrate chains, with N-acetylneuraminic acid (NeuAc) and N-glycolylneuraminic acid (NeuGc) being the two most common sialic-acid residues in mammalian cells. Generally, human healthy tissue is deficient in NeuGc, but this molecule is expressed in tumors and in human fetal tissues, and was hence classified as an onco-fetal antigen. Gangliosides perform important functions through carbohydrate-specific interactions with proteins, for example, as receptors in cell-cell recognition, which can be exploited by viruses and other pathogens, and also by regulating signaling proteins, such as the epidermal growth factor receptor (EGFR) and the vascular endothelial growth factor receptor (VEGFR), through lateral interaction in the membrane. Through both mechanisms, tumor-associated gangliosides may affect malignant progression, which makes them attractive targets for cancer immunotherapies. In this review, we describe how proteins recognize gangliosides, focusing on the molecular recognition of gangliosides associated with cancer immunotherapy, and discuss the importance of these molecules in cancer research.

Keywords: biological membranes; cancer immunotherapy; cell signaling; gangliosides; glycosphingolipids; protein–carbohydrate interactions; sialic acid; tumor-associated antigens

References

  1. Cancer Res. 1985 Jun;45(6):2642-9 - PubMed
  2. Cancer Invest. 2007 Feb;25(1):67-77 - PubMed
  3. Hum Pathol. 2009 Nov;40(11):1517-27 - PubMed
  4. EMBO Rep. 2004 Aug;5(8):777-82 - PubMed
  5. Nature. 1984 Oct 4-10;311(5985):483-5 - PubMed
  6. Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3445-9 - PubMed
  7. Cancer Epidemiol Biomarkers Prev. 2003 Feb;12(2):136-43 - PubMed
  8. Cancer Res. 2006 Nov 1;66(21):10408-14 - PubMed
  9. Pediatr Dev Pathol. 2010 Jan-Feb;13(1):18-23 - PubMed
  10. Nat Chem Biol. 2011 May;7(5):260-2 - PubMed
  11. Cell Immunol. 1992 Jan;139(1):18-29 - PubMed
  12. Glycobiology. 2009 Apr;19(4):344-55 - PubMed
  13. Mol Biol Cell. 1999 Feb;10(2):313-27 - PubMed
  14. J Biol Chem. 1991 Mar 5;266(7):4531-7 - PubMed
  15. J Biol Chem. 2004 Aug 27;279(35):36481-9 - PubMed
  16. Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):18987-91 - PubMed
  17. Arch Biochem Biophys. 2002 Feb 15;398(2):153-9 - PubMed
  18. Jpn J Cancer Res. 1987 Jun;78(6):614-20 - PubMed
  19. Biochem Biophys Res Commun. 1981 Jun;100(4):1578-86 - PubMed
  20. J Lipid Res. 2004 Jan;45(1):1-8 - PubMed
  21. Cold Spring Harb Perspect Biol. 2011 Nov 01;3(11):a004747 - PubMed
  22. Proc Natl Acad Sci U S A. 2011 May 31;108(22):9044-8 - PubMed
  23. BMC Cancer. 2009 Jun 11;9:180 - PubMed
  24. Clin Exp Immunol. 1976 Jul;25(1):122-32 - PubMed
  25. Biotechnol J. 2006 Feb;1(2):138-47 - PubMed
  26. J Neurochem. 2007 Nov;103 Suppl 1:81-90 - PubMed
  27. Prog Lipid Res. 2014 Apr;54:1-13 - PubMed
  28. PLoS Pathog. 2008 Aug 15;4(8):e1000129 - PubMed
  29. Cancer Res. 1996 Jun 15;56(12):2844-8 - PubMed
  30. J Am Chem Soc. 2005 May 25;127(20):7379-86 - PubMed
  31. Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13678-83 - PubMed
  32. Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5219-24 - PubMed
  33. Adv Exp Med Biol. 2011;705:525-48 - PubMed
  34. Eur J Biochem. 2004 Jun;271(12):2428-37 - PubMed
  35. Curr Opin Struct Biol. 2009 Oct;19(5):549-57 - PubMed
  36. Glycoconj J. 2006 Dec;23(9):639-49 - PubMed
  37. Drugs Today (Barc). 2014 Apr;50(4):301-7 - PubMed
  38. Chem Phys Lipids. 1990 Jan;52(1):1-10 - PubMed
  39. Expert Rev Anticancer Ther. 2006 Aug;6(8):1215-23 - PubMed
  40. J Immunol. 1987 Nov 1;139(9):3171-6 - PubMed
  41. Cancer Immunol Immunother. 2014 Jul;63(7):737-47 - PubMed
  42. J Biol Chem. 2003 Dec 5;278(49):48770-8 - PubMed
  43. Biochemistry. 2002 Feb 12;41(6):1742-51 - PubMed
  44. Mol Cell. 1998 Apr;1(5):719-28 - PubMed
  45. J Neurochem. 1963 Sep;10:613-23 - PubMed
  46. Biochim Biophys Acta. 2014 Aug;1841(8):1049-59 - PubMed
  47. Curr Drug Targets. 2008 Apr;9(4):317-24 - PubMed
  48. Commun Integr Biol. 2009 May;2(3):213-4 - PubMed
  49. Nat Rev Mol Cell Biol. 2010 Aug;11(8):593-8 - PubMed
  50. FEBS Lett. 2010 May 3;584(9):1872-8 - PubMed
  51. PLoS One. 2013 Apr 23;8(4):e62559 - PubMed
  52. Structure. 1997 Apr 15;5(4):465-8 - PubMed
  53. Exp Cell Res. 1997 Aug 1;234(2):341-6 - PubMed
  54. Cancer Manag Res. 2012;4:341-5 - PubMed
  55. PLoS One. 2010 Feb 05;5(2):e9079 - PubMed
  56. Cold Spring Harb Perspect Biol. 2011 Apr 01;3(4): - PubMed
  57. Endocr Relat Cancer. 2001 Jun;8(2):83-96 - PubMed
  58. J Biol Chem. 1985 Oct 25;260(24):13328-33 - PubMed
  59. J Biochem. 1995 Dec;118(6):1091-103 - PubMed
  60. J Lipid Res. 2008 May;49(5):929-38 - PubMed
  61. Cancer Lett. 2005 Jul 8;225(1):141-9 - PubMed
  62. Glycobiology. 2007 Jan;17(1):1R-13R - PubMed
  63. Biochemistry. 2003 Dec 23;42(50):14762-73 - PubMed
  64. Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12045-50 - PubMed
  65. Gan. 1984 May;75(5):418-26 - PubMed
  66. Infect Immun. 2004 Mar;72(3):1519-29 - PubMed
  67. CA Cancer J Clin. 1996 Jul-Aug;46(4):225-44 - PubMed
  68. J Mol Biol. 1990 Oct 20;215(4):635-51 - PubMed
  69. Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10662-7 - PubMed
  70. Clin Cancer Res. 2009 Sep 1;15(17):5323-37 - PubMed
  71. Trends Biochem Sci. 2011 Jun;36(6):298-313 - PubMed
  72. Biochim Biophys Acta. 1976 Dec 2;455(2):433-51 - PubMed
  73. J Biol Chem. 2002 Jul 19;277(29):25859-62 - PubMed
  74. J Oleo Sci. 2011;60(10):537-44 - PubMed
  75. Cold Spring Harb Perspect Biol. 2011 Oct 01;3(10):a004697 - PubMed
  76. Protein Sci. 1994 Feb;3(2):166-75 - PubMed
  77. Biochem Biophys Res Commun. 1977 Nov 21;79(2):388-95 - PubMed
  78. J Biol Chem. 1986 Feb 15;261(5):2434-40 - PubMed
  79. J Mol Biol. 2007 Dec 14;374(5):1298-308 - PubMed
  80. PLoS One. 2012;7(4):e35457 - PubMed
  81. Curr Opin Struct Biol. 2008 Oct;18(5):567-76 - PubMed
  82. J Dermatol. 1992 Nov;19(11):827-30 - PubMed
  83. Science. 2013 Dec 20;342(6165):1432-3 - PubMed
  84. Clin Cancer Res. 2014 Jul 15;20(14):3660-71 - PubMed
  85. Clin Dev Immunol. 2011;2011:245181 - PubMed
  86. Biochim Biophys Acta. 1991 Apr 24;1083(1):57-64 - PubMed
  87. Xenotransplantation. 2002 Nov;9(6):376-81 - PubMed
  88. Chang Gung Med J. 2006 Jan-Feb;29(1):37-62 - PubMed
  89. Cancer Res. 1985 Aug;45(8):3796-802 - PubMed
  90. Cell Host Microbe. 2010 Oct 21;8(4):309-19 - PubMed
  91. Molecules. 2012 Aug 10;17(8):9559-72 - PubMed
  92. Future Oncol. 2007 Apr;3(2):201-14 - PubMed
  93. J Clin Oncol. 2013 Oct 20;31(30):3831-7 - PubMed
  94. Biochimie. 2001 Jul;83(7):623-34 - PubMed
  95. Cancer Res. 2006 Jul 1;66(13):6816-25 - PubMed
  96. Cancer Res. 2003 Apr 1;63(7):1676-83 - PubMed
  97. J Biol Chem. 2005 Feb 11;280(6):4228-37 - PubMed
  98. Cancer Res. 1996 Nov 15;56(22):5165-71 - PubMed
  99. Neurosci Lett. 1994 Aug 15;177(1-2):44-6 - PubMed
  100. Chem Rev. 1998 Apr 2;98(2):637-674 - PubMed
  101. Cancer Res. 1996 Dec 1;56(23):5309-18 - PubMed
  102. Glycoconj J. 2013 Oct;30(7):687-99 - PubMed
  103. J Biol Chem. 2009 Mar 6;284(10):6147-55 - PubMed
  104. Int J Cancer. 1987 Jul 15;40(1):12-7 - PubMed
  105. Biochem Biophys Res Commun. 1984 Apr 30;120(2):500-4 - PubMed
  106. Cell Prolif. 2002 Apr;35(2):105-15 - PubMed
  107. Nature. 2003 Dec 18;426(6968):803-9 - PubMed
  108. J Biol Chem. 2004 Feb 13;279(7):5597-603 - PubMed
  109. J Exp Med. 1982 Apr 1;155(4):1133-47 - PubMed
  110. Nat Rev Mol Cell Biol. 2000 Oct;1(1):31-9 - PubMed
  111. J Biol Chem. 1986 Dec 25;261(36):17057-61 - PubMed
  112. Curr Opin Struct Biol. 2011 Dec;21(6):777-84 - PubMed
  113. J Biol Chem. 2002 Jul 19;277(29):25843-6 - PubMed
  114. Cancer Lett. 1996 Apr 19;102(1-2):209-15 - PubMed
  115. Eur J Immunol. 2003 Jun;33(6):1642-8 - PubMed
  116. Biochim Biophys Acta. 1996 Oct 29;1286(3):247-67 - PubMed
  117. Biochim Biophys Acta. 2012 Jul;1818(7):1777-84 - PubMed
  118. Thorax. 2008 Mar;63(3):228-33 - PubMed
  119. Cancer Res. 1987 Feb 15;47(4):1098-104 - PubMed
  120. Jpn J Cancer Res. 1987 Mar;78(3):251-60 - PubMed
  121. Mol Immunol. 2009 Oct;46(16):3466-75 - PubMed
  122. Cell Mol Life Sci. 2006 Jun;63(12):1331-54 - PubMed
  123. Cancer Res. 2006 Mar 15;66(6):2937-45 - PubMed
  124. FEBS Lett. 2010 May 3;584(9):1685-93 - PubMed
  125. Glycoconj J. 2012 Dec;29(8-9):627-37 - PubMed
  126. N Engl J Med. 2004 May 20;350(21):2129-39 - PubMed
  127. Philos Trans R Soc Lond B Biol Sci. 2003 May 29;358(1433):847-61 - PubMed
  128. Glycobiology. 2009 Mar;19(3):229-39 - PubMed
  129. Glycoconj J. 2004;20(5):301-17 - PubMed
  130. Cell. 2013 Jan 31;152(3):557-69 - PubMed
  131. Mol Syst Biol. 2005;1:2005.0010 - PubMed
  132. Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11751-6 - PubMed
  133. Cancer. 1991 Jun 15;67(12):3029-35 - PubMed
  134. Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9142-7 - PubMed
  135. Nature. 2005 Dec 15;438(7070):967-74 - PubMed
  136. J Virol. 2009 Oct;83(19):10275-9 - PubMed
  137. Cancer Sci. 2013 Jan;104(1):43-7 - PubMed
  138. J Biol Chem. 2002 Mar 22;277(12):10108-13 - PubMed
  139. Nature. 1997 Jun 5;387(6633):569-72 - PubMed
  140. Cancer Res. 2000 Dec 1;60(23):6670-6 - PubMed
  141. Eur J Immunol. 2013 Mar;43(3):826-37 - PubMed
  142. Cancer Res. 1989 Mar 1;49(5):1300-5 - PubMed
  143. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19137-42 - PubMed
  144. Int Arch Allergy Appl Immunol. 1978;57(5):477-80 - PubMed
  145. J Biol Chem. 1998 Jun 19;273(25):15866-71 - PubMed
  146. Mol Simul. 2008;34(4):349-363 - PubMed
  147. ACS Chem Biol. 2013 Feb 15;8(2):376-86 - PubMed
  148. Science. 2002 Jul 26;297(5581):573-8 - PubMed

Publication Types