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Matos A, Pereira da Silva A, Clara Bicho M, et al. In women with previous pregnancy hypertension, levels of cardiovascular risk biomarkers may be modulated by haptoglobin polymorphism. Obstet Gynecol Int. 2014;2014:361727doi: 10.1155/2014/361727.
Matos, A., Pereira da Silva, A., Clara Bicho, M., Afonso, C., Areias, M. J., Rebelo, I., & Bicho, M. (2014). In women with previous pregnancy hypertension, levels of cardiovascular risk biomarkers may be modulated by haptoglobin polymorphism. Obstetrics and gynecology international, 2014361727. https://doi.org/10.1155/2014/361727
Matos, Andreia, et al. "In women with previous pregnancy hypertension, levels of cardiovascular risk biomarkers may be modulated by haptoglobin polymorphism." Obstetrics and gynecology international vol. 2014 (2014): 361727. doi: https://doi.org/10.1155/2014/361727
Matos A, Pereira da Silva A, Clara Bicho M, Afonso C, Areias MJ, Rebelo I, Bicho M. In women with previous pregnancy hypertension, levels of cardiovascular risk biomarkers may be modulated by haptoglobin polymorphism. Obstet Gynecol Int. 2014;2014:361727. doi: 10.1155/2014/361727. Epub 2014 Jul 02. PMID: 25101128; PMCID: PMC4102073.
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Obstet Gynecol Int. 2014;2014:361727. doi: 10.1155/2014/361727. Epub 2014 Jul 02.

In women with previous pregnancy hypertension, levels of cardiovascular risk biomarkers may be modulated by haptoglobin polymorphism.

Obstetrics and gynecology international

Andreia Matos, Alda Pereira da Silva, Maria Clara Bicho, Conceição Afonso, Maria José Areias, Irene Rebelo, Manuel Bicho

Affiliations

  1. Genetics Laboratory, Lisbon Medical School, University of Lisbon, 1649-028 Lisbon, Portugal.
  2. Júlio Diniz Maternity, Maria Pia Hospital, 4050-371 Porto, Portugal.
  3. Department of Biochemistry, Faculty of Pharmacy and Institute for Molecular and Cell Biology, University of Porto, 4050-313 Porto, Portugal.
  4. Genetics Laboratory, Lisbon Medical School, University of Lisbon, 1649-028 Lisbon, Portugal ; Rocha Cabral Institute, 1250-047 Lisbon, Portugal.

PMID: 25101128 PMCID: PMC4102073 DOI: 10.1155/2014/361727

Abstract

Preeclampsia (PE) may affect the risk for future cardiovascular disease. Haptoglobin (Hp), an acute phase protein with functional genetic polymorphism, synthesized in the hepatocyte and in many peripheral tissues secondary of oxidative stress of PE, may modulate that risk through the antioxidant, angiogenic, and anti-inflammatory differential effects of their genotypes. We performed a prospective study in 352 women aged 35 ± 5.48 years, which 165 had previous PE, 2 to 16 years ago. We studied demographic, anthropometric, and haemodynamic biomarkers such as C-reactive protein (CRP), myeloperoxidase (MPO), and nitric oxide metabolites (total and nitrites), and others associated with liver function (AST and ALT) and lipid profile (total LDL and cholesterol HDL, non-HDL, and apolipoproteins A and B). Finally, we study the influence of Hp genetic polymorphism on all these biomarkers and as a predisposing factor for PE and its remote cardiovascular disease prognosis. Previously preeclamptic women either hypertensive or normotensive presented significant differences in those risk biomarkers (MPO, nitrites, and ALT), whose variation may be modulated by Hp 1/2 functional genetic polymorphism. The history of PE may be relevant, in association with these biomarkers to the cardiovascular risk in premenopausal women.

References

  1. J Pregnancy. 2012;2012:632732 - PubMed
  2. Circulation. 2013 Feb 12;127(6):668-9 - PubMed
  3. Free Radic Biol Med. 2004 Sep 15;37(6):902-11 - PubMed
  4. Clin Chem. 1996 Oct;42(10):1589-600 - PubMed
  5. Antioxid Redox Signal. 2010 Feb;12(2):293-304 - PubMed
  6. J Zhejiang Univ Sci B. 2005 Nov;6(11):1045-56 - PubMed
  7. Cardiovasc Res. 2014 Mar 15;101(4):579-86 - PubMed
  8. Clin Chim Acta. 2012 Apr 11;413(7-8):669-74 - PubMed
  9. Nitric Oxide. 2008 Jun;18(4):296-302 - PubMed
  10. PLoS One. 2013;8(4):e60479 - PubMed
  11. Pregnancy Hypertens. 2011 Jan;1(1):28-42 - PubMed
  12. Circulation. 2006 Apr 18;113(15):1871-8 - PubMed
  13. Am J Obstet Gynecol. 2012 Apr;206(4):358.e10-8 - PubMed
  14. J Clin Invest. 1993 Mar;91(3):977-85 - PubMed
  15. Int J Biochem Cell Biol. 2002 Apr;34(4):309-14 - PubMed
  16. J Med Genet. 2003 Mar;40(3):214-6 - PubMed
  17. Nat Clin Pract Nephrol. 2005 Dec;1(2):98-114; quiz 120 - PubMed
  18. Hypertens Pregnancy. 2001;20(1):IX-XIV - PubMed
  19. Circ Res. 2006 Dec 8;99(12):1419-25 - PubMed
  20. Clin Chem Lab Med. 2006;44(8):924-8 - PubMed
  21. Mol Hum Reprod. 2001 Aug;7(8):747-54 - PubMed
  22. Fertil Steril. 2008 May;89(5):1090-1094 - PubMed
  23. Atherosclerosis. 2013 Jul;229(1):234-9 - PubMed
  24. Blood. 2006 Jul 1;108(1):353-61 - PubMed
  25. Atherosclerosis. 2007 Mar;191(1):48-53 - PubMed
  26. Clin Chim Acta. 2011 Mar 18;412(7-8):493-8 - PubMed
  27. J Immunol Methods. 1984 Mar 30;68(1-2):185-92 - PubMed
  28. Anal Biochem. 1984 Aug 15;141(1):55-61 - PubMed
  29. Hypertens Pregnancy. 2003;22(2):173-84 - PubMed
  30. J Hypertens. 2013 Oct;31(10):1925-38 - PubMed
  31. Placenta. 2013 Dec;34(12):1177-82 - PubMed
  32. Clin Chim Acta. 2004 Jul;345(1-2):35-42 - PubMed
  33. Endocrine. 2010 Oct;38(2):303-8 - PubMed
  34. J Hum Hypertens. 1997 Apr;11(4):233-8 - PubMed
  35. Biochem Soc Trans. 1979 Jun;7(3):543-5 - PubMed
  36. Am J Obstet Gynecol. 2012 Nov;207(5):407.e1-7 - PubMed
  37. Biochem Biophys Res Commun. 2007 Feb 23;353(4):915-20 - PubMed
  38. Antioxid Redox Signal. 2010 Feb;12(2):261-73 - PubMed
  39. Blood. 2010 Dec 9;116(24):5347-56 - PubMed

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