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Sosnik A. Alginate Particles as Platform for Drug Delivery by the Oral Route: State-of-the-Art. ISRN Pharm. 2014;2014:926157doi: 10.1155/2014/926157.
Sosnik, A. (2014). Alginate Particles as Platform for Drug Delivery by the Oral Route: State-of-the-Art. ISRN pharmaceutics, 2014926157. https://doi.org/10.1155/2014/926157
Sosnik, Alejandro. "Alginate Particles as Platform for Drug Delivery by the Oral Route: State-of-the-Art." ISRN pharmaceutics vol. 2014 (2014): 926157. doi: https://doi.org/10.1155/2014/926157
Sosnik A. Alginate Particles as Platform for Drug Delivery by the Oral Route: State-of-the-Art. ISRN Pharm. 2014 Apr 09;2014:926157. doi: 10.1155/2014/926157. eCollection 2014. PMID: 25101184; PMCID: PMC4004034.
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ISRN Pharm. 2014 Apr 09;2014:926157. doi: 10.1155/2014/926157. eCollection 2014.

Alginate Particles as Platform for Drug Delivery by the Oral Route: State-of-the-Art.

ISRN pharmaceutics

Alejandro Sosnik

Affiliations

  1. Group of Pharmaceutical Nanomaterials Science, Department of Materials Science and Engineering, Technion-Israel Institute of Technology De-Jur Building, Office 607, Technion City, 32000 Haifa, Israel.

PMID: 25101184 PMCID: PMC4004034 DOI: 10.1155/2014/926157

Abstract

Pharmaceutical research and development aims to design products with ensured safety, quality, and efficacy to treat disease. To make the process more rational, coherent, efficient, and cost-effective, the field of Pharmaceutical Materials Science has emerged as the systematic study of the physicochemical properties and behavior of materials of pharmaceutical interest in relation to product performance. The oral route is the most patient preferred for drug administration. The presence of a mucus layer that covers the entire gastrointestinal tract has been exploited to expand the use of the oral route by developing a mucoadhesive drug delivery system that showed a prolonged residence time. Alginic acid and sodium and potassium alginates have emerged as one of the most extensively explored mucoadhesive biomaterials owing to very good cytocompatibility and biocompatibility, biodegradation, sol-gel transition properties, and chemical versatility that make possible further modifications to tailor their properties. The present review overviews the most relevant applications of alginate microparticles and nanoparticles for drug administration by the oral route and discusses the perspectives of this biomaterial in the future.

References

  1. Eur J Pharm Biopharm. 2009 Oct;73(2):205-18 - PubMed
  2. Materials (Basel). 2013 Mar 26;6(4):1285-1309 - PubMed
  3. Int J Nanomedicine. 2011;6:1057-68 - PubMed
  4. J Microencapsul. 2011;28(7):614-20 - PubMed
  5. Int J Pharm. 2007 Dec 10;345(1-2):59-69 - PubMed
  6. J Pharm Sci. 2009 May;98(5):1671-87 - PubMed
  7. Biomaterials. 2006 Sep;27(26):4646-54 - PubMed
  8. J Biomed Mater Res B Appl Biomater. 2012 Jan;100(1):249-55 - PubMed
  9. Int J Pharm. 2009 Jul 6;376(1-2):92-8 - PubMed
  10. Expert Opin Drug Deliv. 2012 Mar;9(3):303-23 - PubMed
  11. Biomaterials. 1999 Jan;20(1):45-53 - PubMed
  12. Biomaterials. 2012 Jun;33(18):4752-61 - PubMed
  13. Int J Pharm. 2010 Jun 30;393(1-2):212-8 - PubMed
  14. Int J Antimicrob Agents. 2006 May;27(5):409-16 - PubMed
  15. Carbohydr Res. 1972 Dec;25(2):273-82 - PubMed
  16. J Control Release. 2000 Sep 3;68(3):397-404 - PubMed
  17. Biomaterials. 2008 Mar;29(9):1207-15 - PubMed
  18. Int Immunopharmacol. 2008 Dec 20;8(13-14):1773-80 - PubMed
  19. World J Gastroenterol. 1999 Feb;5(1):57-60 - PubMed
  20. Eur J Pharm Biopharm. 2008 Nov;70(3):777-83 - PubMed
  21. J Drug Target. 2012 Jan;20(1):76-84 - PubMed
  22. J Nanomater. 2011;2011(2011): - PubMed
  23. J Pharm Sci. 1993 Sep;82(9):912-7 - PubMed
  24. Biotechnol Appl Biochem. 2009 Dec 21;55(1):1-8 - PubMed
  25. AAPS J. 2009 Dec;11(4):740-6 - PubMed
  26. Biomaterials. 2002 Sep;23(18):3825-31 - PubMed
  27. AAPS PharmSciTech. 2011 Dec;12(4):1335-47 - PubMed
  28. Expert Opin Drug Deliv. 2008 Apr;5(4):417-25 - PubMed
  29. Eur J Pharm Biopharm. 2001 Mar;51(2):127-33 - PubMed
  30. Biomacromolecules. 2011 Apr 11;12(4):889-97 - PubMed
  31. Int J Pharm. 2007 Jul 18;339(1-2):3-18 - PubMed
  32. Biomaterials. 2006 Nov;27(32):5603-17 - PubMed
  33. Int J Pharm. 2011 Jun 30;412(1-2):123-31 - PubMed
  34. PLoS Negl Trop Dis. 2012;6(11):e1894 - PubMed
  35. Int J Pharm. 2006 Apr 7;312(1-2):113-8 - PubMed
  36. Biomed Microdevices. 2010 Feb;12(1):145-51 - PubMed
  37. N Engl J Med. 1993 Jun 10;328(23):1676-85 - PubMed
  38. Int J Pharm. 2012 May 10;427(2):417-25 - PubMed
  39. Eur J Pharm Sci. 2007 Sep;32(1):17-23 - PubMed
  40. J Microencapsul. 2009 Mar;26(2):143-53 - PubMed
  41. Recent Pat Drug Deliv Formul. 2012 Dec;6(3):259-77 - PubMed
  42. Biotechnol Bioeng. 2003 Aug 5;83(3):282-92 - PubMed
  43. Biomacromolecules. 2011 Nov 14;12(11):4095-103 - PubMed
  44. J Biomater Sci Polym Ed. 2012;23(1-4):315-31 - PubMed
  45. J Pharm Sci. 2007 Oct;96(10):2547-65 - PubMed
  46. Colloids Surf B Biointerfaces. 2010 Dec 1;81(2):521-9 - PubMed
  47. Eur J Pharm Sci. 2009 Feb 15;36(2-3):226-34 - PubMed
  48. Adv Drug Deliv Rev. 2006 Jul 7;58(4):487-99 - PubMed
  49. Nanomedicine. 2007 Sep;3(3):239-43 - PubMed
  50. AAPS PharmSciTech. 2008;9(1):224-30 - PubMed
  51. J Microencapsul. 2009 Nov;26(7):563-70 - PubMed
  52. Indian J Pharm Sci. 2012 Jul;74(4):319-30 - PubMed
  53. Drug Deliv Transl Res. 2011 Aug;1(4):289-98 - PubMed
  54. Pharm Res. 1995 Mar;12(3):413-20 - PubMed
  55. J Control Release. 2006 Sep 12;114(3):348-58 - PubMed
  56. J Biomed Mater Res A. 2012 Oct;100(10):2637-43 - PubMed
  57. Drug Deliv. 2011 Jan;18(1):26-37 - PubMed
  58. Int J Pharm. 2008 Feb 12;349(1-2):226-33 - PubMed
  59. J Biomed Mater Res. 2002 May;60(2):217-23 - PubMed
  60. Biomaterials. 2011 Mar;32(8):2174-82 - PubMed
  61. J Pharm Pharm Sci. 1998 Jan-Apr;1(1):15-30 - PubMed
  62. Adv Drug Deliv Rev. 2010 Jun 15;62(7-8):711-30 - PubMed
  63. Eur J Pharm Sci. 2013 May 13;49(2):272-7 - PubMed
  64. Adv Drug Deliv Rev. 2013 Aug;65(9):1148-71 - PubMed
  65. Prog Polym Sci. 2012 Jan;37(1):106-126 - PubMed
  66. J Biosci Bioeng. 2012 Feb;113(2):133-40 - PubMed
  67. J Microencapsul. 2004 Dec;21(8):829-39 - PubMed
  68. Drug Dev Ind Pharm. 2012 Dec;38(12):1486-93 - PubMed
  69. Biomacromolecules. 2007 Oct;8(10):3054-60 - PubMed
  70. Eur J Pharm Biopharm. 2012 Jan;80(1):67-75 - PubMed
  71. Sci Pharm. 2011 Sep;79(3):673-94 - PubMed
  72. Langmuir. 2012 Mar 6;28(9):4131-41 - PubMed
  73. Electrophoresis. 1992 May;13(5):269-74 - PubMed
  74. Eur J Pharm Biopharm. 2007 Mar;65(3):354-62 - PubMed
  75. Maturitas. 2012 Sep;73(1):5-18 - PubMed
  76. Adv Drug Deliv Rev. 2012 May 1;64(6):557-70 - PubMed
  77. Eur J Pharm Biopharm. 2011 Jan;77(1):11-9 - PubMed
  78. Langmuir. 2010 Dec 21;26(24):19066-72 - PubMed
  79. Colloids Surf B Biointerfaces. 2009 Feb 1;68(2):245-9 - PubMed
  80. Macromol Biosci. 2005 Sep 16;5(9):881-9 - PubMed
  81. Cartilage. 2012 Jan;3(1):70-8 - PubMed
  82. J Biomed Mater Res. 2001 Jan;54(1):76-86 - PubMed
  83. Am J Physiol Gastrointest Liver Physiol. 2001 May;280(5):G922-9 - PubMed
  84. Eur J Pharm Sci. 2007 Aug;31(5):249-61 - PubMed
  85. Chem Pharm Bull (Tokyo). 2008 Aug;56(8):1077-84 - PubMed
  86. Drug Dev Ind Pharm. 2001 Apr;27(4):309-19 - PubMed
  87. Biomaterials. 2012 Apr;33(11):3279-305 - PubMed
  88. J Pharm Pharmacol. 2012 Apr;64(4):530-40 - PubMed
  89. J Biomater Appl. 1998 Jan;12(3):249-57 - PubMed
  90. Trends Biotechnol. 1990 Mar;8(3):71-8 - PubMed
  91. Int J Nanomedicine. 2012;7:4679-95 - PubMed
  92. J Biomater Sci Polym Ed. 2006;17(8):909-24 - PubMed
  93. Langmuir. 2008 Apr 15;24(8):4092-6 - PubMed
  94. Eur J Pharm Sci. 2010 Jul 11;40(4):359-66 - PubMed
  95. Colloids Surf B Biointerfaces. 2013 Sep 1;109:301-6 - PubMed
  96. J Pharm Pharmacol. 1997 Feb;49(2):119-26 - PubMed
  97. J Pharm Sci. 2008 Aug;97(8):2892-923 - PubMed
  98. Eur J Pharm Biopharm. 2008 Mar;68(3):565-78 - PubMed
  99. Nanomedicine. 2009 Sep;5(3):316-22 - PubMed
  100. Biomacromolecules. 2001 Winter;2(4):1089-96 - PubMed
  101. Drug Dev Ind Pharm. 2007 Jun;33(6):667-76 - PubMed
  102. Acta Biomater. 2009 Sep;5(7):2475-84 - PubMed
  103. J Drug Target. 2010 Dec;18(10):831-41 - PubMed
  104. Int J Pharm. 2007 Aug 16;341(1-2):1-19 - PubMed
  105. J Biomed Mater Res A. 2007 Sep 15;82(4):892-8 - PubMed
  106. Drug Deliv. 2012 Apr;19(3):123-31 - PubMed
  107. Pharm Res. 2010 Feb;27(2):264-71 - PubMed
  108. Int J Pharm. 2008 Mar 3;351(1-2):104-12 - PubMed
  109. J Nanosci Nanotechnol. 2007 Aug;7(8):2833-41 - PubMed
  110. AAPS PharmSciTech. 2012 Dec;13(4):1147-57 - PubMed
  111. Drug Metab Pharmacokinet. 2011;26(1):3-14 - PubMed
  112. J Control Release. 2006 Aug 10;114(1):1-14 - PubMed
  113. J Pharm Sci. 2009 Nov;98(11):4285-95 - PubMed
  114. Biomaterials. 2000 Sep;21(17):1797-802 - PubMed
  115. Int J Pharm. 2007 Apr 4;334(1-2):71-7 - PubMed
  116. Drug Dev Ind Pharm. 2010 Apr;36(4):482-9 - PubMed
  117. J Microencapsul. 2012;29(1):63-71 - PubMed
  118. Biomaterials. 1987 Nov;8(6):449-57 - PubMed
  119. Expert Opin Drug Deliv. 2011 Aug;8(8):1085-104 - PubMed
  120. Int J Pharm. 2005 Sep 14;301(1-2):268-76 - PubMed
  121. Gut. 1970 May;11(5):450-6 - PubMed
  122. Biotechnol Bioeng. 2007 Apr 1;96(5):977-89 - PubMed
  123. Int J Biol Macromol. 2012 Jul-Aug;51(1-2):45-55 - PubMed
  124. Ann R Coll Surg Engl. 1986 Jan;68(1):27-8 - PubMed
  125. Indian J Pharm Sci. 2008 Jan;70(1):77-84 - PubMed
  126. Curr Drug Deliv. 2011 Sep;8(5):494-510 - PubMed
  127. J Immunother (1991). 1991 Aug;10(4):286-91 - PubMed
  128. Arch Pharm Res. 2011 Jun;34(6):919-29 - PubMed
  129. J Interferon Cytokine Res. 2012 Jul;32(7):299-311 - PubMed
  130. AAPS PharmSciTech. 2005 Sep 30;6(2):E209-22 - PubMed
  131. Curr Drug Deliv. 2010 Jul;7(3):238-43 - PubMed
  132. Nanomedicine (Lond). 2007 Apr;2(2):183-202 - PubMed
  133. J Microencapsul. 2006 May;23(3):245-57 - PubMed
  134. Pharm Res. 2007 Dec;24(12):2198-206 - PubMed
  135. Eur J Pharm Sci. 2007 Nov;32(3):231-9 - PubMed
  136. Drug Dev Ind Pharm. 2002 Jul;28(6):621-30 - PubMed
  137. Int J Pharm. 2009 Feb 9;367(1-2):127-32 - PubMed
  138. J Biomater Sci Polym Ed. 2010;21(6-7):701-13 - PubMed
  139. Biomaterials. 1999 Aug;20(15):1427-35 - PubMed
  140. Eur J Pharm Sci. 2007 Apr;30(5):392-7 - PubMed

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