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Hughes CE, Williams PA, Harris KD. "CLASSIC NMR": an in-situ NMR strategy for mapping the time-evolution of crystallization processes by combined liquid-state and solid-state measurements. Angew Chem Int Ed Engl. 2014;53(34):8939-43doi: 10.1002/anie.201404266.
Hughes, C. E., Williams, P. A., & Harris, K. D. (2014). "CLASSIC NMR": an in-situ NMR strategy for mapping the time-evolution of crystallization processes by combined liquid-state and solid-state measurements. Angewandte Chemie (International ed. in English), 53(34), 8939-43. https://doi.org/10.1002/anie.201404266
Hughes, Colan E, et al. ""CLASSIC NMR": an in-situ NMR strategy for mapping the time-evolution of crystallization processes by combined liquid-state and solid-state measurements." Angewandte Chemie (International ed. in English) vol. 53,34 (2014): 8939-43. doi: https://doi.org/10.1002/anie.201404266
Hughes CE, Williams PA, Harris KD. "CLASSIC NMR": an in-situ NMR strategy for mapping the time-evolution of crystallization processes by combined liquid-state and solid-state measurements. Angew Chem Int Ed Engl. 2014 Aug 18;53(34):8939-43. doi: 10.1002/anie.201404266. Epub 2014 Jul 07. PMID: 25044662; PMCID: PMC4227553.
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Angew Chem Int Ed Engl. 2014 Aug 18;53(34):8939-43. doi: 10.1002/anie.201404266. Epub 2014 Jul 07.

"CLASSIC NMR": an in-situ NMR strategy for mapping the time-evolution of crystallization processes by combined liquid-state and solid-state measurements.

Angewandte Chemie (International ed. in English)

Colan E Hughes, P Andrew Williams, Kenneth D M Harris

Affiliations

  1. School of Chemistry, Cardiff University, Cardiff CF10 3AT, Wales (UK).

PMID: 25044662 PMCID: PMC4227553 DOI: 10.1002/anie.201404266

Abstract

A new in-situ NMR strategy (termed CLASSIC NMR) for mapping the evolution of crystallization processes is reported, involving simultaneous measurement of both liquid-state and solid-state NMR spectra as a function of time. This combined strategy allows complementary information to be obtained on the evolution of both the solid and liquid phases during the crystallization process. In particular, as crystallization proceeds (monitored by solid-state NMR), the solution state becomes more dilute, leading to changes in solution-state speciation and the modes of molecular aggregation in solution, which are monitored by liquid-state NMR. The CLASSIC NMR experiment is applied here to yield new insights into the crystallization of m-aminobenzoic acid.

© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords: crystal growth; in-situ studies; solid-state nmr spectroscopy; time-dependent processes

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