Display options
Cite
Kang HJ, Moon HS, Chung HW. The expression of FAS-associated factor 1 and heat shock protein 70 in ovarian cancer. Obstet Gynecol Sci. 2014;57(4):281-90doi: 10.5468/ogs.2014.57.4.281.
Kang, H. J., Moon, H. S., & Chung, H. W. (2014). The expression of FAS-associated factor 1 and heat shock protein 70 in ovarian cancer. Obstetrics & gynecology science, 57(4), 281-90. https://doi.org/10.5468/ogs.2014.57.4.281
Kang, Hye-Ju, et al. "The expression of FAS-associated factor 1 and heat shock protein 70 in ovarian cancer." Obstetrics & gynecology science vol. 57,4 (2014): 281-90. doi: https://doi.org/10.5468/ogs.2014.57.4.281
Kang HJ, Moon HS, Chung HW. The expression of FAS-associated factor 1 and heat shock protein 70 in ovarian cancer. Obstet Gynecol Sci. 2014 Jul;57(4):281-90. doi: 10.5468/ogs.2014.57.4.281. Epub 2014 Jul 15. PMID: 25105101; PMCID: PMC4124089.
Copy Download .nbib Format: NLM
Share it on

Obstet Gynecol Sci. 2014 Jul;57(4):281-90. doi: 10.5468/ogs.2014.57.4.281. Epub 2014 Jul 15.

The expression of FAS-associated factor 1 and heat shock protein 70 in ovarian cancer.

Obstetrics & gynecology science

Hye-Ju Kang, Hye-Sung Moon, Hye-Won Chung

Affiliations

  1. Mizpark Obstetrics and Gynecology, Incheon, Korea.
  2. Department of Obstetrics and Gynecology, Ewha Womans University School of Medicine, Seoul, Korea.

PMID: 25105101 PMCID: PMC4124089 DOI: 10.5468/ogs.2014.57.4.281

Abstract

OBJECTIVE: In this study, we evaluated the expression of FAS-associated factor 1 (FAF1) and heat shock protein 70 (HSP70) in normal ovary and ovarian cancer, and also analyzed the correlation between FAF1 and HSP70 in ovarian cancer.

METHODS: The patient group consisted of 29 unrelated Korean women diagnosed as ovarian cancers and control samples were obtained from 7 patients who underwent oophorectomy for benign disease of uterus, and normal ovary was confirmed histologically from biopsy. We examined FAF1 and HSP70 expression by western blot analysis and immunohistochemical staining in normal ovary and ovarian cancer. Furthermore, we examined a correlation between FAF1 and HSP70 in ovarian cancer.

RESULTS: The expression of FAF1 was lower in ovarian cancer than that in normal ovary (P=0.02), and the expression of HSP70 was increased in ovarian cancer in comparison to that in normal ovary (P=0.03). The expression of FAF1 was decreased in advanced stages (stage III or stage IV) as compared with early stages (stage I or stage II) (P=0.01). The expression of HSP70 was not significantly related with ovarian cancer histology (P=0.10), but the expression of HSP70 was most increased with papillary serous carcinomas and undifferentiated ovarian cancer. The expression of FAF1 was inversely correlated with the expression of HSP70 in ovarian cancer (Spearman correlation coefficience=-0.47).

CONCLUSION: We concluded that the expression of FAF1 or HSP70 each seems to have a meaning as a biomarker for early detection of ovarian cancer. The expressions of FAF1 and HSP70 seem to be more valuable in predicting ovarian cancer when used together because of their inverse correlation. This is the first study about the expression of FAF1 in ovarian cancer and the correlation between FAF1 and HSP70 expression in ovarian cancer.

Keywords: FAS-associated factor 1; HSP70 heat-shock proteins; Ovarian neoplasms

References

  1. Hum Reprod. 1989 Jan;4(1):1-12 - PubMed
  2. Science. 1995 Sep 15;269(5230):1585-8 - PubMed
  3. J Exp Med. 2004 Aug 16;200(4):425-35 - PubMed
  4. Cell Cycle. 2009 Aug 15;8(16):2528-34 - PubMed
  5. Expert Rev Mol Diagn. 2010 Sep;10(6):787-98 - PubMed
  6. Int J Gynecol Pathol. 1983;2(3):275-85 - PubMed
  7. Pathol Oncol Res. 1998;4(4):316-21 - PubMed
  8. Oral Oncol. 1998 Mar;34(2):93-8 - PubMed
  9. Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11894-8 - PubMed
  10. Cell. 1998 Feb 6;92(3):351-66 - PubMed
  11. Biochem Biophys Res Commun. 2001 Sep 7;286(5):1027-32 - PubMed
  12. Int J Oncol. 2003 Oct;23(4):1015-23 - PubMed
  13. Womens Health (Lond). 2010 Jul;6(4):487-90 - PubMed
  14. Cancer. 1995 Nov 15;76(10 Suppl):2092-6 - PubMed
  15. J Korean Med Sci. 1998 Aug;13(4):383-8 - PubMed
  16. Mol Cancer. 2008 May 19;7:40 - PubMed
  17. Drug Resist Updat. 2008 Aug-Oct;11(4-5):164-79 - PubMed
  18. Am J Gastroenterol. 2009 Mar;104(3):630-8 - PubMed
  19. Eur J Cancer Prev. 1998 Jun;7(3):225-31 - PubMed
  20. Nature. 1996 Jun 13;381(6583):571-9 - PubMed
  21. Exp Cell Res. 2003 Feb 1;283(1):1-16 - PubMed
  22. Am J Respir Cell Mol Biol. 1994 Apr;10(4):453-61 - PubMed
  23. BMC Cancer. 2005 Jul 09;5:77 - PubMed
  24. Int J Cancer. 2001 Aug 15;93(4):481-8 - PubMed
  25. Breast Cancer Res Treat. 1997 Mar;43(1):43-51 - PubMed
  26. Nat Rev Drug Discov. 2009 Jan;8(1):33-40 - PubMed
  27. Cancer Detect Prev. 1998;22(6):549-55 - PubMed
  28. Cancer Res. 2007 Feb 15;67(4):1735-43 - PubMed
  29. Int J Hyperthermia. 2000 Sep-Oct;16(5):445-8 - PubMed
  30. J Immunol. 1993 Oct 15;151(8):4286-94 - PubMed
  31. J Biol Chem. 2004 Jan 23;279(4):2544-9 - PubMed
  32. Hepatology. 2003 Jan;37(1):198-207 - PubMed
  33. Nat Med. 2000 Apr;6(4):435-42 - PubMed
  34. J Biol Chem. 2005 Mar 4;280(9):8125-33 - PubMed
  35. Gynecol Oncol. 1992 Feb;44(2):147-54 - PubMed
  36. Oncogene. 2008 Oct 20;27(48):6216-27 - PubMed
  37. Blood. 2009 Mar 26;113(13):3059-69 - PubMed

Publication Types