Display options
Cite
Schoenberg PL, Speckens AE. Modulation of induced frontocentral theta (Fm-θ) event-related (de-)synchronisation dynamics following mindfulness-based cognitive therapy in Major Depressive Disorder. Cogn Neurodyn. 2014;8(5):373-88doi: 10.1007/s11571-014-9294-0.
Schoenberg, P. L., & Speckens, A. E. (2014). Modulation of induced frontocentral theta (Fm-θ) event-related (de-)synchronisation dynamics following mindfulness-based cognitive therapy in Major Depressive Disorder. Cognitive neurodynamics, 8(5), 373-88. https://doi.org/10.1007/s11571-014-9294-0
Schoenberg, Poppy L A, and Speckens, Anne E M. "Modulation of induced frontocentral theta (Fm-θ) event-related (de-)synchronisation dynamics following mindfulness-based cognitive therapy in Major Depressive Disorder." Cognitive neurodynamics vol. 8,5 (2014): 373-88. doi: https://doi.org/10.1007/s11571-014-9294-0
Schoenberg PL, Speckens AE. Modulation of induced frontocentral theta (Fm-θ) event-related (de-)synchronisation dynamics following mindfulness-based cognitive therapy in Major Depressive Disorder. Cogn Neurodyn. 2014 Oct;8(5):373-88. doi: 10.1007/s11571-014-9294-0. Epub 2014 May 07. PMID: 25206931; PMCID: PMC4155066.
Copy Download .nbib Format: NLM
Share it on

Cogn Neurodyn. 2014 Oct;8(5):373-88. doi: 10.1007/s11571-014-9294-0. Epub 2014 May 07.

Modulation of induced frontocentral theta (Fm-θ) event-related (de-)synchronisation dynamics following mindfulness-based cognitive therapy in Major Depressive Disorder.

Cognitive neurodynamics

Poppy L A Schoenberg, Anne E M Speckens

Affiliations

  1. Faculty of Science, Intelligent Systems, Radboud University Nijmegen, Postbus 9010, 6500 GL Nijmegen, The Netherlands ; Department of Cognitive Neuroscience, Radboud University Medical Centre Nijmegen, Nijmegen, The Netherlands ; Netherlands Institute for Advanced Study, Wassenaar, The Netherlands.
  2. Department of Psychiatry, Radboud University Medical Centre Nijmegen, Nijmegen, The Netherlands.

PMID: 25206931 PMCID: PMC4155066 DOI: 10.1007/s11571-014-9294-0

Abstract

Depressive severity has been associated with attenuated neocortical frontal midline theta (Fm-θ) power/evoked activity. Mindfulness-Based Cognitive Therapy (MBCT) has shown to be a successful novel intervention for Major Depressive Disorder (MDD), albeit precise working mechanisms remain elusive. We examined the hypothesis that MBCT would have modulating effects upon evoked Fm-θ power, in addition to investigating possible mediation of induced event-related de/synchronisation (ERD/ERS) dynamics. Fifty one patients with a primary diagnosis of MDD (26 exposed to MBCT vs. 25 wait-list/WL controls) undertook a Go/NoGo task consisting of positive, negative and neutral words, further stratified into abstract versus trait adjective matrices. Depressive symptom severity and rumination were also examined. A pattern of enhanced induced Fm-θ synchronisation during the latter 400-800 ms temporal-window pre-to-post MBCT was observed; the contrary in the WL. Modulated ERD/ERS dynamics correlated to amelioration in depressive and rumination symptoms in the MBCT group. We propose the primary action pathway alluded to a neural disengagement mechanism enacting upon tonic neuronal assemblies implicated in emotional and self-related processing. Due to the complexity and presently undiscovered complete unified scientific understanding of neuro-oscillatory-dynamics, and associated clinical interplays; we hypothesise that the electro-cortical and connected clinical working pathways of MBCT in depression are multi-levelled constituting nonlinear and interdependent mechanisms, represented by mediated EEG synchronisation dynamics.

Keywords: Event-related (de-)synchronisation (ERD/ERS); Fm-theta; Major Depressive Disorder (MDD); Mindfulness-Based Cognitive Therapy (MBCT); Oscillatory EEG; Rumination

References

  1. Nat Rev Neurosci. 2011 Aug 10;12(9):509-23 - PubMed
  2. Psychol Med. 1996 May;26(3):477-86 - PubMed
  3. Hippocampus. 2005;15(7):881-9 - PubMed
  4. Psychol Med. 2012 May;42(5):989-1001 - PubMed
  5. Psychophysiology. 2007 Mar;44(2):293-304 - PubMed
  6. Perspect Psychol Sci. 2011 Nov;6(6):537-59 - PubMed
  7. Trends Cogn Sci. 2011 Feb;15(2):85-93 - PubMed
  8. J Pers Soc Psychol. 1991 Jul;61(1):115-21 - PubMed
  9. Psychiatry Res. 2000 Mar 6;93(2):153-64 - PubMed
  10. Psychopharmacology (Berl). 2006 Jul;187(1):103-11 - PubMed
  11. Prog Neurobiol. 2008 Nov;86(3):156-85 - PubMed
  12. J ECT. 2001 Jun;17(2):136-40 - PubMed
  13. Mol Psychiatry. 2002;7 Suppl 1:S71-80 - PubMed
  14. Electroencephalogr Clin Neurophysiol. 1995 May;94(5):381-4 - PubMed
  15. Ann N Y Acad Sci. 2003 Nov;1003:250-72 - PubMed
  16. Biol Psychiatry. 2011 Aug 15;70(4):327-33 - PubMed
  17. Conscious Cogn. 2010 Dec;19(4):1110-8 - PubMed
  18. Brain Res Cogn Brain Res. 2001 Jun;11(3):363-76 - PubMed
  19. Psychophysiology. 2003 Nov;40(6):939-49 - PubMed
  20. Clin Neurophysiol. 2007 Mar;118(3):645-68 - PubMed
  21. J Neural Transm (Vienna). 2006 Oct;113(10):1477-86 - PubMed
  22. Neurosci Lett. 2001 Sep 7;310(1):57-60 - PubMed
  23. J Anxiety Disord. 2008 May;22(4):716-21 - PubMed
  24. J Consult Clin Psychol. 2011 Oct;79(5):618-28 - PubMed
  25. Psychol Sci. 2013 Mar 1;24(3):334-44 - PubMed
  26. Neuropsychiatr Dis Treat. 2011;7(Suppl 1):9-13 - PubMed
  27. Behav Res Ther. 2012 May;50(5):292-7 - PubMed
  28. Neurosci Lett. 2008 Oct 17;444(1):1-4 - PubMed
  29. Prog Neurobiol. 1995 Apr;45(6):523-83 - PubMed
  30. Biol Psychol. 1977 Mar;5(1):47-82 - PubMed
  31. Clin Neurophysiol. 2004 Aug;115(8):1821-35 - PubMed
  32. Neuropsychopharmacology. 2003 May;28(5):857-64 - PubMed
  33. Neuropsychologia. 2010 Jan;48(2):619-26 - PubMed
  34. J Consult Clin Psychol. 2004 Feb;72(1):31-40 - PubMed
  35. Int J Psychophysiol. 2009 Feb;71(2):156-69 - PubMed
  36. Scand J Psychol. 2013 Apr;54(2):118-26 - PubMed
  37. Neuroimage. 2010 May 1;50(4):1666-75 - PubMed
  38. J Affect Disord. 2002 May;69(1-3):241-9 - PubMed
  39. Neurosci Lett. 2000 Jan 14;278(3):141-4 - PubMed
  40. Int J Psychophysiol. 2003 Nov;50(3):205-12 - PubMed
  41. J Affect Disord. 2011 Jun;131(1-3):214-23 - PubMed
  42. J Cogn Neurosci. 2007 Jan;19(1):158-72 - PubMed
  43. J Clin Psychol. 2006 Feb;62(2):201-10 - PubMed
  44. Am J Psychiatry. 2001 Mar;158(3):405-15 - PubMed
  45. Int J Psychophysiol. 2008 Mar;67(3):242-51 - PubMed
  46. Can J Psychiatry. 2004 Mar;49(3 Suppl 1):10S-16S - PubMed
  47. Neuroreport. 2010 Apr 21;21(6):410-5 - PubMed
  48. Neuropsychopharmacology. 2011 Jan;36(1):183-206 - PubMed
  49. Cortex. 2003 Sep-Dec;39(4-5):967-92 - PubMed
  50. Cereb Cortex. 1997 Jun;7(4):374-85 - PubMed
  51. J Consult Clin Psychol. 2000 Aug;68(4):615-23 - PubMed
  52. BMC Psychiatry. 2012 Feb 29;12:15 - PubMed
  53. Clin Neurophysiol. 2009 Jul;120(7):1313-9 - PubMed
  54. Behav Res Ther. 2007 Mar;45(3):617-25 - PubMed
  55. J Affect Disord. 2007 Mar;98(3):215-25 - PubMed
  56. J Affect Disord. 2008 Apr;107(1-3):275-9 - PubMed
  57. Psychiatry Res. 2001 Nov 30;108(2):111-21 - PubMed
  58. Eur J Neurosci. 2002 Apr;15(8):1395-9 - PubMed
  59. Assessment. 2008 Sep;15(3):329-42 - PubMed
  60. Neuroimage. 2010 Nov 1;53(2):757-68 - PubMed

Publication Types