J Sports Sci Med. 2014 Sep 01;13(3):590-6. eCollection 2014 Sep.
Physical Fitness Measures as Potential Markers of Low Cognitive Function in Japanese Community-Dwelling Older Adults without Apparent Cognitive Problems.
Journal of sports science & medicine
Kenji Narazaki, Eri Matsuo, Takanori Honda, Yu Nofuji, Koji Yonemoto, Shuzo Kumagai
Affiliations
Affiliations
- Graduate School of Human-Environment Studies, Kyushu University , Fukuoka, Japan.
- Tokyo Metropolitan Institute of Gerontology , Tokyo, Japan.
- Biostatistics Center, Kurume University , Fukuoka, Japan.
- Graduate School of Human-Environment Studies, Kyushu University , Fukuoka, Japan ; Faculty of Arts and Science, Kyushu University , Fukuoka, Japan.
PMID: 25177186
PMCID: PMC4126296
Abstract
Detecting signs of cognitive impairment as early as possible is one of the most urgent challenges in preventive care of dementia. It has still been unclear whether physical fitness measures can serve as markers of low cognitive function, a sign of cognitive impairment, in older people free from dementia. The aim of the present study was to examine an association between each of five physical fitness measures and global cognition in Japanese community-dwelling older adults without apparent cognitive problems. The baseline research of the Sasaguri Genkimon Study was conducted from May to August 2011 in Sasaguri town, Fukuoka, Japan. Of the 2,629 baseline subjects who were aged 65 years or older and not certified as individuals requiring nursing care by the town, 1,552 participants without apparent cognitive problems (Mini-Mental State Examination score ≥24) were involved in the present study (59.0% of the baseline subjects, median age: 72 years, men: 40.1%). Global cognitive function was measured by the Japanese version of the Montreal Cognitive Assessment. Handgrip strength, leg strength, sit-to-stand rate, gait speed, and one-leg stand time were examined as physical fitness measures. In multiple linear regression analyses, each of the five physical fitness measures was positively associated with the Montreal Cognitive Assessment score after adjusting for age and sex (p < 0.001). These associations were preserved after additional adjustment for years of formal education, body mass index, and other confounding factors (p < 0.001). The present study first demonstrated the associations between multiple aspects of physical fitness and global cognitive function in Japanese community-dwelling older people without apparent cognitive problems. These results suggest that each of the physical fitness measures has a potential as a single marker of low cognitive function in older populations free from dementia and thereby can be useful in community-based preventive care of dementia. Key pointsThere is a great need for identifying lifestyle-related markers which help detect subtle cognitive impairment in the preclinical or earlier phase of dementia.In the present study, each of the five physical fitness measures employed was linearly and positively associated with the Montreal Cognitive Assessment score in the present older adults without apparent cognitive problems, after adjusting for age, sex, education, body mass index, and other confounding factors.The results suggest the potential of each physical fitness measure as a single lifestyle-related marker of low cognitive function in the population, which can be useful in community-based preventive care of dementia.
Keywords: Cognitive screening; community-based study; cross-sectional study; mild cognitive impairment; physical function; primary prevention
References
- Arch Intern Med. 2006 May 22;166(10):1115-20 - PubMed
- J Neurosci. 2003 Apr 15;23(8):3295-301 - PubMed
- J Gerontol A Biol Sci Med Sci. 2007 Nov;62(11):1244-51 - PubMed
- J Gerontol A Biol Sci Med Sci. 2013 Aug;68(8):929-37 - PubMed
- JAMA. 2007 Jun 6;297(21):2391-404 - PubMed
- J Nutr Health Aging. 2011 Jan;15(1):22-4 - PubMed
- J Am Geriatr Soc. 2005 Apr;53(4):695-9 - PubMed
- Geriatr Gerontol Int. 2010 Jul;10(3):225-32 - PubMed
- J Am Geriatr Soc. 2012 Sep;60(9):1681-6 - PubMed
- Stroke. 2010 Jun;41(6):1290-3 - PubMed
- J Am Geriatr Soc. 2007 Feb;55(2):245-51 - PubMed
- Alzheimers Dement. 2011 May;7(3):280-92 - PubMed
- Alzheimers Dement. 2013 Jan;9(1):1-11.e3 - PubMed
- Br J Nutr. 2011 Jun;105(11):1681-91 - PubMed
- AJNR Am J Neuroradiol. 2013 Apr;34(4):797-801 - PubMed
- Neuroepidemiology. 2013;40(1):23-9 - PubMed
- Neuroepidemiology. 2007;29(1-2):66-73 - PubMed
- Psychiatry Clin Neurosci. 2011 Aug;65(5):434-41 - PubMed
- J Alzheimers Dis. 2011;26(4):709-18 - PubMed
- Arch Gerontol Geriatr. 1991 Sep-Oct;13(2):103-16 - PubMed
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