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Merilainen A, Peuhkurinen S, Honkasalo T, et al. Combined first-trimester screening in northern Finland: experiences of the first ten years. Clin Med Insights Reprod Health. 2014;8:45-9doi: 10.4137/CMRH.S14958.
Merilainen, A., Peuhkurinen, S., Honkasalo, T., Laitinen, P., Kokkonen, H., Ryynanen, M., & Marttala, J. (2014). Combined first-trimester screening in northern Finland: experiences of the first ten years. Clinical medicine insights. Reproductive health, 845-9. https://doi.org/10.4137/CMRH.S14958
Merilainen, Anna, et al. "Combined first-trimester screening in northern Finland: experiences of the first ten years." Clinical medicine insights. Reproductive health vol. 8 (2014): 45-9. doi: https://doi.org/10.4137/CMRH.S14958
Merilainen A, Peuhkurinen S, Honkasalo T, Laitinen P, Kokkonen H, Ryynanen M, Marttala J. Combined first-trimester screening in northern Finland: experiences of the first ten years. Clin Med Insights Reprod Health. 2014 Jul 30;8:45-9. doi: 10.4137/CMRH.S14958. eCollection 2014. PMID: 25140118; PMCID: PMC4130568.
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Clin Med Insights Reprod Health. 2014 Jul 30;8:45-9. doi: 10.4137/CMRH.S14958. eCollection 2014.

Combined first-trimester screening in northern Finland: experiences of the first ten years.

Clinical medicine insights. Reproductive health

Anna Merilainen, Sini Peuhkurinen, Timppa Honkasalo, Paivi Laitinen, Hannaleena Kokkonen, Markku Ryynanen, Jaana Marttala

Affiliations

  1. Department of Obstetrics and Gynecology, Oulu University Hospital, Finland.
  2. Clinical Chemistry and Hematology, Helsinki University Hospital, Finland.

PMID: 25140118 PMCID: PMC4130568 DOI: 10.4137/CMRH.S14958

Abstract

OBJECTIVE: To evaluate the efficacy of first trimester combined screening for Down's syndrome in Northern Finland during the first 10 years of practice.

METHODS: During 1 January 2002 to 31 December 2011, 47,896 women participated voluntarily in combined screening during first trimester. The risk cutoff was 1:250. The study period was divided into two time periods; 2002-2006 and 2007-2011.

RESULTS: During the first half of the study period, the detection rate (DR) was 77.3% with a 4.9% false-positive rate (FPR). During the latter half, the DR was 77.1% with a 2.8% FPR.

CONCLUSIONS: An important issue is the number of invasive procedures needed to detect one case of Down's syndrome. The screening performance improved markedly in the latter five years period since the FPR lowered from 4.9% to 2.8% and the number of invasive procedures needed to detect one case of Down's syndrome lowered from 15 to 11.

Keywords: Down’s syndrome; combined screening; first trimester; nuchal translucency; singleton pregnancy

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