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Hashemian SM, Mortaz E, Tabarsi P, et al. Elevated CXCL-8 expression in bronchoalveolar lavage correlates with disease severity in patients with acute respiratory distress syndrome resulting from tuberculosis. J Inflamm (Lond). 2014;11:21doi: 10.1186/1476-9255-11-21.
Hashemian, S. M., Mortaz, E., Tabarsi, P., Jamaati, H., Maghsoomi, Z., Khosravi, A., Garssen, J., Masjedi, M. R., Velayati, A. A., Folkerts, G., Barnes, P. J., & Adcock, I. M. (2014). Elevated CXCL-8 expression in bronchoalveolar lavage correlates with disease severity in patients with acute respiratory distress syndrome resulting from tuberculosis. Journal of inflammation (London, England), 1121. https://doi.org/10.1186/1476-9255-11-21
Hashemian, Seyed Mohamad Reza, et al. "Elevated CXCL-8 expression in bronchoalveolar lavage correlates with disease severity in patients with acute respiratory distress syndrome resulting from tuberculosis." Journal of inflammation (London, England) vol. 11 (2014): 21. doi: https://doi.org/10.1186/1476-9255-11-21
Hashemian SM, Mortaz E, Tabarsi P, Jamaati H, Maghsoomi Z, Khosravi A, Garssen J, Masjedi MR, Velayati AA, Folkerts G, Barnes PJ, Adcock IM. Elevated CXCL-8 expression in bronchoalveolar lavage correlates with disease severity in patients with acute respiratory distress syndrome resulting from tuberculosis. J Inflamm (Lond). 2014 Aug 05;11:21. doi: 10.1186/1476-9255-11-21. eCollection 2014. PMID: 25110464; PMCID: PMC4126912.
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J Inflamm (Lond). 2014 Aug 05;11:21. doi: 10.1186/1476-9255-11-21. eCollection 2014.

Elevated CXCL-8 expression in bronchoalveolar lavage correlates with disease severity in patients with acute respiratory distress syndrome resulting from tuberculosis.

Journal of inflammation (London, England)

Seyed Mohamad Reza Hashemian, Esmaeil Mortaz, Payam Tabarsi, Hamidreza Jamaati, Zohreh Maghsoomi, Adnan Khosravi, Johan Garssen, Mohamad Reza Masjedi, Ali Akbar Velayati, Gert Folkerts, Peter J Barnes, Ian M Adcock

Affiliations

  1. Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  2. Division of Pharmacology and Pathophysiology Utrecht Institute for Pharmaceutical Sciences, Faculty of Sciences, Utrecht University, Utrecht, The Netherlands ; Department of Infectious Diseases, Mycobacteriology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  3. Department of Infectious Diseases, Mycobacteriology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  4. Division of Pharmacology and Pathophysiology Utrecht Institute for Pharmaceutical Sciences, Faculty of Sciences, Utrecht University, Utrecht, The Netherlands ; Danone Research Centre for Specialised Nutrition, Wageningen, The Netherlands.
  5. Division of Pharmacology and Pathophysiology Utrecht Institute for Pharmaceutical Sciences, Faculty of Sciences, Utrecht University, Utrecht, The Netherlands.
  6. Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, UK.

PMID: 25110464 PMCID: PMC4126912 DOI: 10.1186/1476-9255-11-21

Abstract

BACKGROUND: Tuberculosis (TB) is a rare but known cause of acute respiratory distress syndrome (ARDS). The role of inflammatory cytokines in the progression of ARDS in TB patients is unknown.

OBJECTIVES: In this study we investigated the possible link between the levels of inflammatory cytokines in bronchoalveolar lavage (BAL) in patients with TB or ARDS alone or in patients with TB-induced ARDS (ARDS + TB).

METHODS: 90 patients were studied: 30 with TB alone, 30 with ARDS alone and 30 with ARDS + TB. BAL was collected by fiberoptic bronchoscopy and the concentrations of interleukin(IL)-6, CXCL8, TNF-α and IL-1β and the amounts of total protein were measured by ELISA and bicinchoninic acid assay (BCA) methods respectively. The correlation between disease severity measured by Murray scores, SOFA and APACHE II analysis and BAL mediators and cells was also determined.

RESULTS: CXCL8 levels in BAL were significantly higher in the ARDS + TB group compared to TB and ARDS alone groups. Disease severity in the ARDS + TB group as determined by Murray score correlated with BAL CXCL8 and neutrophils but not with IL-6, IL-1β and TNF-α concentrations. In addition, CXCL8 levels and neutrophils were increased in non-miliary TB versus miliary TB. This difference in CXCL8 was lost in the presence of ARDS.

CONCLUSIONS: BAL CXCL8 levels were significantly higher in patients with ARDS induced by TB and could suggest an important role of CXCL8 in the pathogenesis of this form of ARDS. This further suggests that CXCL8 inhibitors or blockers may be useful to control the onset and/or development of these combined diseases.

Keywords: ARDS; CXCL8 and neutrophils; TB

References

  1. Crit Care Med. 2002 Aug;30(8):1717-21 - PubMed
  2. Eur Respir J. 2006 Jun;27(6):1223-8 - PubMed
  3. Int J Tuberc Lung Dis. 2003 Apr;7(4):359-64 - PubMed
  4. J Immunol. 2007 Mar 15;178(6):3767-76 - PubMed
  5. Crit Care Med. 1985 Oct;13(10):818-29 - PubMed
  6. Chest. 1995 Nov;108(5):1303-14 - PubMed
  7. Crit Care Med. 1981 Aug;9(8):591-7 - PubMed
  8. JAMA. 2012 Jun 20;307(23):2526-33 - PubMed
  9. Infect Immun. 1993 Aug;61(8):3111-6 - PubMed
  10. Intensive Care Med. 2001 Mar;27(3):513-20 - PubMed
  11. Clin Exp Immunol. 1993 Feb;91(2):282-6 - PubMed
  12. J Immunol. 1999 Oct 1;163(7):3936-47 - PubMed
  13. Mol Med. 2001 Oct;7(10):685-97 - PubMed
  14. Int J Tuberc Lung Dis. 2011 Aug;15(8):1099-103 - PubMed
  15. J Immunol. 1995 Aug 15;155(4):2151-7 - PubMed
  16. Inflamm Res. 2006 Dec;55(12):528-33 - PubMed
  17. Am J Respir Crit Care Med. 1996 Jun;153(6 Pt 1):1850-6 - PubMed
  18. J Infect. 2013 Apr;66(4):357-65 - PubMed
  19. Respir Med. 2008 Feb;102(2):280-6 - PubMed
  20. N Engl J Med. 2000 May 4;342(18):1334-49 - PubMed
  21. Am J Physiol Lung Cell Mol Physiol. 2012 Oct 15;303(8):L634-9 - PubMed
  22. J Clin Invest. 2012 Aug;122(8):2731-40 - PubMed
  23. J Immunol. 2004 Feb 1;172(3):1768-76 - PubMed
  24. Lancet. 1993 Mar 13;341(8846):643-7 - PubMed
  25. Eur Respir J. 2003 Jul;22(1):141-7 - PubMed
  26. Clin Microbiol Rev. 2002 Apr;15(2):294-309 - PubMed
  27. Surg Infect (Larchmt). 2010 Apr;11(2):161-7 - PubMed
  28. Am Rev Respir Dis. 1988 Sep;138(3):720-3 - PubMed
  29. World J Surg. 1996 May;20(4):422-9 - PubMed
  30. Int J Tuberc Lung Dis. 2006 Apr;10(4):429-35 - PubMed
  31. Eur Respir J. 2010 Dec;36(6):1242-7 - PubMed
  32. Int J Tuberc Lung Dis. 2009 Mar;13(3):335-40 - PubMed
  33. Clin Exp Immunol. 1993 Jan;91(1):58-62 - PubMed
  34. J Clin Invest. 1995 Feb;95(2):586-92 - PubMed
  35. Ann Intern Med. 1996 Aug 1;125(3):191-6 - PubMed
  36. J Biol Chem. 2005 Jan 14;280(2):1292-8 - PubMed
  37. Intensive Care Med. 1996 Jul;22(7):707-10 - PubMed
  38. Am J Respir Crit Care Med. 1995 Mar;151(3 Pt 1):867-72 - PubMed
  39. Eur Respir J. 2000 May;15(5):895-901 - PubMed
  40. Eur J Immunol. 1992 Jun;22(6):1373-8 - PubMed
  41. Indian J Chest Dis Allied Sci. 1996 Jul-Sep;38(3):157-62 - PubMed
  42. Respirology. 2007 May;12(3):406-11 - PubMed
  43. Mem Inst Oswaldo Cruz. 2009 Nov;104(7):1039-41 - PubMed

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