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Phiske MM. An approach to acanthosis nigricans. Indian Dermatol Online J. 2014;5(3):239-49doi: 10.4103/2229-5178.137765.
Phiske, M. M. (2014). An approach to acanthosis nigricans. Indian dermatology online journal, 5(3), 239-49. https://doi.org/10.4103/2229-5178.137765
Phiske, Meghana Madhukar. "An approach to acanthosis nigricans." Indian dermatology online journal vol. 5,3 (2014): 239-49. doi: https://doi.org/10.4103/2229-5178.137765
Phiske MM. An approach to acanthosis nigricans. Indian Dermatol Online J. 2014 Jul;5(3):239-49. doi: 10.4103/2229-5178.137765. PMID: 25165638; PMCID: PMC4144206.
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Indian Dermatol Online J. 2014 Jul;5(3):239-49. doi: 10.4103/2229-5178.137765.

An approach to acanthosis nigricans.

Indian dermatology online journal

Meghana Madhukar Phiske

Affiliations

  1. Assistant Professor, Department of Dermatology, L.T.M.M.C and General Hospital, Sion, Mumbai, Maharashtra, India.

PMID: 25165638 PMCID: PMC4144206 DOI: 10.4103/2229-5178.137765

Abstract

Acanthosis nigricans (AN) is characterized by dark, coarse and thickened skin with a velvety texture, being symmetrically distributed on the neck, the axillae, antecubital and popliteal fossae, and groin folds, histopathologically characterized by papillomatosis and hyperkeratosis of the skin. A high prevalence of AN has been observed recently. Different varieties of AN include benign, obesity associated, syndromic, malignant, acral, unilateral, medication-induced and mixed AN. Diagnosis is largely clinical with histopathology needed only for confirmation. Other investigations needed are fasting lipoprotein profile, fasting glucose, fasting insulin, hemoglobin and alanine aminotransferase for obesity associated AN and radiological investigations (plain radiography, ultrasonography, magnetic resonance imaging/computerized tomography) for malignancy associated AN. The most common treatment modalities include retinoids and metformin.

Keywords: Acanthosis nigricans; insulin resistance; obesity

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