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Dong J, Cai F, Shen R, et al. Hypoglycaemic effects and inhibitory effect on intestinal disaccharidases of oat beta-glucan in streptozotocin-induced diabetic mice. Food Chem. 2011;129(3):1066-71doi: 10.1016/j.foodchem.2011.05.076.
Dong, J., Cai, F., Shen, R., & Liu, Y. (2011). Hypoglycaemic effects and inhibitory effect on intestinal disaccharidases of oat beta-glucan in streptozotocin-induced diabetic mice. Food chemistry, 129(3), 1066-71. https://doi.org/10.1016/j.foodchem.2011.05.076
Dong, Jilin, et al. "Hypoglycaemic effects and inhibitory effect on intestinal disaccharidases of oat beta-glucan in streptozotocin-induced diabetic mice." Food chemistry vol. 129,3 (2011): 1066-71. doi: https://doi.org/10.1016/j.foodchem.2011.05.076
Dong J, Cai F, Shen R, Liu Y. Hypoglycaemic effects and inhibitory effect on intestinal disaccharidases of oat beta-glucan in streptozotocin-induced diabetic mice. Food Chem. 2011 Dec 01;129(3):1066-71. doi: 10.1016/j.foodchem.2011.05.076. Epub 2011 May 25. PMID: 25212338.
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Food Chem. 2011 Dec 01;129(3):1066-71. doi: 10.1016/j.foodchem.2011.05.076. Epub 2011 May 25.

Hypoglycaemic effects and inhibitory effect on intestinal disaccharidases of oat beta-glucan in streptozotocin-induced diabetic mice.

Food chemistry

Jilin Dong, Fengli Cai, Ruiling Shen, Yanqi Liu

Affiliations

  1. School of Food and Biological Engineering, Zhengzhou University of Light Industry, Dongfeng Road, Zhengzhou, China.
  2. School of Food and Biological Engineering, Zhengzhou University of Light Industry, Dongfeng Road, Zhengzhou, China. Electronic address: [email protected].

PMID: 25212338 DOI: 10.1016/j.foodchem.2011.05.076

Abstract

Most physiological studies on oat beta (β)-glucan referred to attenuation of blood glucose and insulin responses in both healthy and diabetic individuals. The main purpose of this work was to evaluate the effects of oat β-glucan on glucose metabolism in streptozotocin-induced diabetic mice and the activities of intestinal disaccharidases in the diabetic mice and in vitro. Meanwhile, the potentially regulative mechanisms on intestinal disaccharidases were discussed. Normal and diabetic mice, treated with metformin, were used as the negative and positive controls, respectively. The results indicated that oat β-glucan could regulate the glucose metabolism and inhibit the activities of intestinal disaccharidases in vivo and in vitro (p<0.01), especially when using a high-dose, which suggested that oat β-glucan could effectively improve the internal environment of intestinal tract and would be a potential alpha (α)-glycosidase inhibitor.

Copyright © 2011 Elsevier Ltd. All rights reserved.

Keywords: Hypoglycaemic effects; Intestinal disaccharidase; Oat β-glucan; Type 2 diabetes mellitus

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