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Söyüt H, Kaya ED, Beydemir S. Impact of antibacterial drugs on human serum paraoxonase-1 (hPON1) activity: an in vitro study. Asian Pac J Trop Biomed. 2014;4(8):603-9doi: 10.12980/APJTB.4.2014APJTB-2014-0059.
Söyüt, H., Kaya, E. D., & Beydemir, S. (2014). Impact of antibacterial drugs on human serum paraoxonase-1 (hPON1) activity: an in vitro study. Asian Pacific journal of tropical biomedicine, 4(8), 603-9. https://doi.org/10.12980/APJTB.4.2014APJTB-2014-0059
Söyüt, Hakan, et al. "Impact of antibacterial drugs on human serum paraoxonase-1 (hPON1) activity: an in vitro study." Asian Pacific journal of tropical biomedicine vol. 4,8 (2014): 603-9. doi: https://doi.org/10.12980/APJTB.4.2014APJTB-2014-0059
Söyüt H, Kaya ED, Beydemir S. Impact of antibacterial drugs on human serum paraoxonase-1 (hPON1) activity: an in vitro study. Asian Pac J Trop Biomed. 2014 Aug;4(8):603-9. doi: 10.12980/APJTB.4.2014APJTB-2014-0059. PMID: 25183328; PMCID: PMC4037652.
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Asian Pac J Trop Biomed. 2014 Aug;4(8):603-9. doi: 10.12980/APJTB.4.2014APJTB-2014-0059.

Impact of antibacterial drugs on human serum paraoxonase-1 (hPON1) activity: an in vitro study.

Asian Pacific journal of tropical biomedicine

Hakan Söyüt, Elif Duygu Kaya, Sükrü Beydemir

Affiliations

  1. Department of Primary Education, Faculty of Education, Bayburt University, 69000 Bayburt, Turkey.
  2. Department of Food Engineering, Faculty of Engineering, I?d?r University, 76000 I?d?r, Turkey.
  3. Department of Chemistry, Faculty of Science, Atatürk University, 25240 Erzurum, Turkey.

PMID: 25183328 PMCID: PMC4037652 DOI: 10.12980/APJTB.4.2014APJTB-2014-0059

Abstract

OBJECTIVE: To investigate the in vitro effects of the antibacterial drugs, meropenem trihydrate, piperacillin sodium, and cefoperazone sodium, on the activity of human serum paraoxonase (hPON1).

METHODS: hPON1 was purified from human serum using simple chromatographic methods, including DEAE-Sephadex anion exchange and Sephadex G-200 gel filtration chromatography.

RESULTS: The three antibacterial drugs decreased in vitro hPON1 activity. Inhibition mechanisms meropenem trihydrate was noncompetitive while piperacillin sodium and cefoperazone sodium were competitive.

CONCLUSIONS: Our results showed that antibacterial drugs significantly inhibit hPON1 activity, both in vitro, with rank order meropenem trihydrate piperacillin sodium cefoperazone sodium in vitro.

Keywords: Cefoperazone sodium; Inhibition; Meropenem trihydrate; Paraoxonase; Piperacillin sodium

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