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Puertollano R. mTOR and lysosome regulation. F1000Prime Rep. 2014;6:52doi: 10.12703/P6-52.
Puertollano, R. (2014). mTOR and lysosome regulation. F1000prime reports, 652. https://doi.org/10.12703/P6-52
Puertollano, Rosa. "mTOR and lysosome regulation." F1000prime reports vol. 6 (2014): 52. doi: https://doi.org/10.12703/P6-52
Puertollano R. mTOR and lysosome regulation. F1000Prime Rep. 2014 Jul 08;6:52. doi: 10.12703/P6-52. eCollection 2014. PMID: 25184042; PMCID: PMC4108950.
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F1000Prime Rep. 2014 Jul 08;6:52. doi: 10.12703/P6-52. eCollection 2014.

mTOR and lysosome regulation.

F1000prime reports

Rosa Puertollano

Affiliations

  1. Cell Biology and Physiology Center, National Heart, Lung, and Blood Institute, National Institutes of Health 9000 Rockville Pike, Bldg. 50/3537, Bethesda, MD 20892 USA.

PMID: 25184042 PMCID: PMC4108950 DOI: 10.12703/P6-52

Abstract

Lysosomes are key cellular organelles that play a crucial role in catabolism by degrading extracellular and intracellular material. It is, therefore, very intriguing that mTORC1 (mechanistic target of rapamycin complex 1), a major promoter of anabolic processes, localizes in its active form to the surface of lysosomes. In recent years, many exciting observations have revealed a tightly regulated crosstalk between mTORC1 activity and lysosomal function. These findings highlight the complex regulatory network that modulates energy metabolism in cells.

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