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Calkins ME, Moore TM, Merikangas KR, et al. The psychosis spectrum in a young U.S. community sample: findings from the Philadelphia Neurodevelopmental Cohort. World Psychiatry. 2014;13(3):296-305doi: 10.1002/wps.20152.
Calkins, M. E., Moore, T. M., Merikangas, K. R., Burstein, M., Satterthwaite, T. D., Bilker, W. B., Ruparel, K., Chiavacci, R., Wolf, D. H., Mentch, F., Qiu, H., Connolly, J. J., Sleiman, P. A., Hakonarson, H., Gur, R. C., & Gur, R. E. (2014). The psychosis spectrum in a young U.S. community sample: findings from the Philadelphia Neurodevelopmental Cohort. World psychiatry : official journal of the World Psychiatric Association (WPA), 13(3), 296-305. https://doi.org/10.1002/wps.20152
Calkins, Monica E, et al. "The psychosis spectrum in a young U.S. community sample: findings from the Philadelphia Neurodevelopmental Cohort." World psychiatry : official journal of the World Psychiatric Association (WPA) vol. 13,3 (2014): 296-305. doi: https://doi.org/10.1002/wps.20152
Calkins ME, Moore TM, Merikangas KR, Burstein M, Satterthwaite TD, Bilker WB, Ruparel K, Chiavacci R, Wolf DH, Mentch F, Qiu H, Connolly JJ, Sleiman PA, Hakonarson H, Gur RC, Gur RE. The psychosis spectrum in a young U.S. community sample: findings from the Philadelphia Neurodevelopmental Cohort. World Psychiatry. 2014 Oct;13(3):296-305. doi: 10.1002/wps.20152. PMID: 25273303; PMCID: PMC4219071.
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World Psychiatry. 2014 Oct;13(3):296-305. doi: 10.1002/wps.20152.

The psychosis spectrum in a young U.S. community sample: findings from the Philadelphia Neurodevelopmental Cohort.

World psychiatry : official journal of the World Psychiatric Association (WPA)

Monica E Calkins, Tyler M Moore, Kathleen R Merikangas, Marcy Burstein, Theodore D Satterthwaite, Warren B Bilker, Kosha Ruparel, Rosetta Chiavacci, Daniel H Wolf, Frank Mentch, Haijun Qiu, John J Connolly, Patrick A Sleiman, Hakon Hakonarson, Ruben C Gur, Raquel E Gur

Affiliations

  1. Department of Psychiatry, Neuropsychiatry Section, Perelman School of Medicine, University of Pennsylvania, 9 Maloney, 3600 Spruce Street, Philadelphia, PA, 19104, USA.

PMID: 25273303 PMCID: PMC4219071 DOI: 10.1002/wps.20152

Abstract

Little is known about the occurrence and predictors of the psychosis spectrum in large non-clinical community samples of U.S. youths. We aimed to bridge this gap through assessment of psychosis spectrum symptoms in the Philadelphia Neurodevelopmental Cohort, a collaborative investigation of clinical and neurobehavioral phenotypes in a prospectively accrued cohort of youths, funded by the National Institute of Mental Health. Youths (age 11-21; N=7,054) and collateral informants (caregiver/legal guardian) were recruited through the Children's Hospital of Philadelphia and administered structured screens of psychosis spectrum symptoms, other major psychopathology domains, and substance use. Youths were also administered a computerized neurocognitive battery assessing five neurobehavioral domains. Predictors of psychosis spectrum status in physically healthy participants (N=4,848) were examined using logistic regression. Among medically healthy youths, 3.7% reported threshold psychotic symptoms (delusions and/or hallucinations). An additional 12.3% reported significant sub-psychotic positive symptoms, with odd/unusual thoughts and auditory perceptions, followed by reality confusion, being the most discriminating and widely endorsed attenuated symptoms. A minority of youths (2.3%) endorsed subclinical negative/disorganized symptoms in the absence of positive symptoms. Caregivers reported lower symptom levels than their children. Male gender, younger age, and non-European American ethnicity were significant predictors of spectrum status. Youths with spectrum symptoms had reduced accuracy across neurocognitive domains, reduced global functioning, and increased odds of depression, anxiety, behavioral disorders, substance use and suicidal ideation. These findings have public health relevance for prevention and early intervention.

Copyright © 2014 World Psychiatric Association.

Keywords: Psychosis spectrum; U.S. youths; functional impairment; neurocognition; sub-psychotic positive symptoms

References

  1. Addiction. 1999 Jul;94(7):981-93 - PubMed
  2. Arch Gen Psychiatry. 2000 Nov;57(11):1053-8 - PubMed
  3. Schizophr Res. 2008 Dec;106(2-3):356-62 - PubMed
  4. Am J Psychiatry. 2010 Sep;167(9):1075-82 - PubMed
  5. Pediatrics. 2010 Jan;125(1):75-81 - PubMed
  6. Br J Psychiatry Suppl. 2007 Dec;51:s31-7 - PubMed
  7. Schizophr Bull. 2011 Jan;37(1):84-93 - PubMed
  8. J Am Acad Child Adolesc Psychiatry. 2009 Apr;48(4):367-379 - PubMed
  9. J Am Acad Child Adolesc Psychiatry. 2010 Oct;49(10):980-9 - PubMed
  10. Schizophr Res. 2011 Apr;127(1-3):252-6 - PubMed
  11. Psychol Med. 2002 Feb;32(2):347-58 - PubMed
  12. Psychol Med. 2012 Nov;42(11):2239-53 - PubMed
  13. Arch Gen Psychiatry. 2008 Jan;65(1):28-37 - PubMed
  14. Can J Psychiatry. 2013 Jan;58(1):32-40 - PubMed
  15. Am J Psychiatry. 2009 May;166(5):567-74 - PubMed
  16. Psychol Med. 2012 Sep;42(9):1857-63 - PubMed
  17. Psychol Med. 2009 Feb;39(2):179-95 - PubMed
  18. Early Interv Psychiatry. 2010 Aug;4(3):200-5 - PubMed
  19. Psychol Med. 2012 Jul;42(7):1495-506 - PubMed
  20. Psychol Med. 2011 Nov;41(11):2317-29 - PubMed
  21. Curr Pharm Des. 2012;18(4):399-415 - PubMed
  22. J Child Psychol Psychiatry. 1998 Jul;39(5):711-20 - PubMed
  23. Psychol Med. 2014 Jan;44(1):17-24 - PubMed
  24. JAMA Psychiatry. 2013 Jan;70(1):107-20 - PubMed
  25. Actas Esp Psiquiatr. 2007 Nov-Dec;35(6):368-71 - PubMed
  26. Cogn Neuropsychiatry. 2013;18(1-2):9-25 - PubMed
  27. Acta Psychiatr Scand. 2008 Sep;118(3):230-7 - PubMed
  28. Neuropsychology. 2012 Mar;26(2):251-265 - PubMed
  29. Schizophr Bull. 2008 Mar;34(2):220-5 - PubMed
  30. Arch Gen Psychiatry. 1983 Nov;40(11):1228-31 - PubMed
  31. Schizophr Bull. 2012 Sep;38(5):992-1002 - PubMed
  32. Arch Gen Psychiatry. 2012 Jun;69(6):562-71 - PubMed
  33. Schizophr Res. 2006 May;84(1):67-76 - PubMed
  34. Aust N Z J Psychiatry. 2008 Jun;42(6):505-8 - PubMed
  35. Early Interv Psychiatry. 2014 May;8(2):104-12 - PubMed

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