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Wang P, Wang B, Chung S, et al. Increased chemopreventive effect by combining arctigenin, green tea polyphenol and curcumin in prostate and breast cancer cells. RSC Adv. 2014;4(66):35242-35250doi: 10.1039/C4RA06616B.
Wang, P., Wang, B., Chung, S., Wu, Y., Henning, S. M., & Vadgama, J. V. (2014). Increased chemopreventive effect by combining arctigenin, green tea polyphenol and curcumin in prostate and breast cancer cells. RSC advances, 4(66), 35242-35250. https://doi.org/10.1039/C4RA06616B
Wang, Piwen, et al. "Increased chemopreventive effect by combining arctigenin, green tea polyphenol and curcumin in prostate and breast cancer cells." RSC advances vol. 4,66 (2014): 35242-35250. doi: https://doi.org/10.1039/C4RA06616B
Wang P, Wang B, Chung S, Wu Y, Henning SM, Vadgama JV. Increased chemopreventive effect by combining arctigenin, green tea polyphenol and curcumin in prostate and breast cancer cells. RSC Adv. 2014 Aug 05;4(66):35242-35250. doi: 10.1039/C4RA06616B. PMID: 25243063; PMCID: PMC4166488.
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RSC Adv. 2014 Aug 05;4(66):35242-35250. doi: 10.1039/C4RA06616B.

Increased chemopreventive effect by combining arctigenin, green tea polyphenol and curcumin in prostate and breast cancer cells.

RSC advances

Piwen Wang, Bin Wang, Seyung Chung, Yanyuan Wu, Susanne M Henning, Jaydutt V Vadgama

Affiliations

  1. Division of Cancer Research and Training, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA ; Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
  2. Division of Cancer Research and Training, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA.
  3. Division of Cancer Research and Training, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA ; David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
  4. Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

PMID: 25243063 PMCID: PMC4166488 DOI: 10.1039/C4RA06616B

Abstract

The low bioavailability of most flavonoids limits their application as anti-carcinogenic agents in humans. A novel approach of treatment with a mixture of bioactive compounds that share molecular anti-carcinogenic targets may enhance the effect on these targets at low concentrations of individual compound, thereby overcoming the limitations of reduced bioavailability. We therefore investigated whether a combination of three natural products arctigenin (Arc), a novel anti-inflammatory lignan from the seeds of

Keywords: Curcumin; arctigenin; breast cancer; combination; green tea polyphenol; prostate cancer

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