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Wu SY, Man KM, Shen JL, et al. Effect of Flos carthami Extract and α 1-Adrenergic Antagonists on the Porcine Proximal Ureteral Peristalsis. Evid Based Complement Alternat Med. 2014;2014:437803doi: 10.1155/2014/437803.
Wu, S. Y., Man, K. M., Shen, J. L., Chen, H. Y., Chang, C. H., Tsai, F. J., Hsieh, W. T., Winardi, D., Lee, Y. J., Tsai, K. S., Lin, Y. N., Chen, Y. H., & Chen, W. C. (2014). Effect of Flos carthami Extract and α 1-Adrenergic Antagonists on the Porcine Proximal Ureteral Peristalsis. Evidence-based complementary and alternative medicine : eCAM, 2014437803. https://doi.org/10.1155/2014/437803
Wu, San-Yuan, et al. "Effect of Flos carthami Extract and α 1-Adrenergic Antagonists on the Porcine Proximal Ureteral Peristalsis." Evidence-based complementary and alternative medicine : eCAM vol. 2014 (2014): 437803. doi: https://doi.org/10.1155/2014/437803
Wu SY, Man KM, Shen JL, Chen HY, Chang CH, Tsai FJ, Hsieh WT, Winardi D, Lee YJ, Tsai KS, Lin YN, Chen YH, Chen WC. Effect of Flos carthami Extract and α 1-Adrenergic Antagonists on the Porcine Proximal Ureteral Peristalsis. Evid Based Complement Alternat Med. 2014;2014:437803. doi: 10.1155/2014/437803. Epub 2014 Jul 09. PMID: 25170340; PMCID: PMC4120800.
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Evid Based Complement Alternat Med. 2014;2014:437803. doi: 10.1155/2014/437803. Epub 2014 Jul 09.

Effect of Flos carthami Extract and α 1-Adrenergic Antagonists on the Porcine Proximal Ureteral Peristalsis.

Evidence-based complementary and alternative medicine : eCAM

San-Yuan Wu, Kee-Ming Man, Jui-Lung Shen, Huey-Yi Chen, Chiao-Hui Chang, Fuu-Jen Tsai, Wen-Tsong Hsieh, Daniel Winardi, Yuan-Ju Lee, Kao-Sung Tsai, Yu-Ning Lin, Yung-Hsiang Chen, Wen-Chi Chen

Affiliations

  1. Department of Anesthesiology, Tungs' Taichung MetroHarbor Hospital, Taichung 435, Taiwan ; Graduate Institute of Integrated Medicine, Institute of Chinese Medicine, School of Chinese Medicine, Department of Pharmacology, Research Center for Chinese Medicine and Acupuncture, China Medical University, Taichung 404, Taiwan.
  2. Department of Anesthesiology, Tungs' Taichung MetroHarbor Hospital, Taichung 435, Taiwan ; Graduate Institute of Integrated Medicine, Institute of Chinese Medicine, School of Chinese Medicine, Department of Pharmacology, Research Center for Chinese Medicine and Acupuncture, China Medical University, Taichung 404, Taiwan ; Department of Medicinal Botanicals and Health Applications, Da-Yeh University, Changhua 515, Taiwan ; Department of Life Sciences, National Chung Hsing University, Taichung 402, Taiwan ; Graduate Institute of Geriatric Medicine, Anhui Medical University, Hefei 230032, China.
  3. Department of Dermatology, Taichung Veterans General Hospital, Taichung 407, Taiwan.
  4. Graduate Institute of Integrated Medicine, Institute of Chinese Medicine, School of Chinese Medicine, Department of Pharmacology, Research Center for Chinese Medicine and Acupuncture, China Medical University, Taichung 404, Taiwan ; Departments of Obstetrics and Gynecology, Medical Genetics and Pediatrics, Dermatology, Medical Research, and Urology, China Medical University Hospital, Taichung 404, Taiwan.
  5. Graduate Institute of Integrated Medicine, Institute of Chinese Medicine, School of Chinese Medicine, Department of Pharmacology, Research Center for Chinese Medicine and Acupuncture, China Medical University, Taichung 404, Taiwan.
  6. Department of Urology, National Taiwan University Hospital, Taipei 100, Taiwan.

PMID: 25170340 PMCID: PMC4120800 DOI: 10.1155/2014/437803

Abstract

Traditional Chinese medicine (TCM) has been proposed to prevent urolithiasis. In China, Flos carthami (FC, also known as Carthamus tinctorius) (Safflower; Chinese name: Hong Hua/) has been used to treat urological diseases for centuries. We previously performed a screening and confirmed the in vivo antilithic effect of FC extract. Here, ex vivo organ bath experiment was further performed to study the effect of FC extract on the inhibition of phenylepinephrine (PE) (10(-4) and 10(-3) M) ureteral peristalsis of porcine ureters with several α 1-adrenergic antagonists (doxazosin, tamsulosin, and terazosin) as experimental controls. The results showed that doxazosin, tamsulosin, and terazosin dose (approximately 4.5 × 10(-6) - 4.5 × 10(-1) μg/mL) dependently inhibited both 10(-4) and 10(-3) M PE-induced ureteral peristalsis. FC extract achieved 6.2% ± 10.1%, 21.8% ± 6.8%, and 24.0% ± 5.6% inhibitions of 10(-4) M PE-induced peristalsis at doses of 5 × 10(3), 1 × 10(4), and 2 × 10(4) μg/mL, respectively, since FC extract was unable to completely inhibit PE-induced ureteral peristalsis, suggesting the antilithic effect of FC extract is related to mechanisms other than modulation of ureteral peristalsis.

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