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Khosravi R, Trackman PC. Diabetes-induced fibrotic matrix inhibits intramembranous bone healing. J Cell Commun Signal. 2014;9(1):19-26doi: 10.1007/s12079-014-0242-x.
Khosravi, R., & Trackman, P. C. (2015). Diabetes-induced fibrotic matrix inhibits intramembranous bone healing. Journal of cell communication and signaling, 9(1), 19-26. https://doi.org/10.1007/s12079-014-0242-x
Khosravi, Roozbeh, and Trackman, Philip C. "Diabetes-induced fibrotic matrix inhibits intramembranous bone healing." Journal of cell communication and signaling vol. 9,1 (2015): 19-26. doi: https://doi.org/10.1007/s12079-014-0242-x
Khosravi R, Trackman PC. Diabetes-induced fibrotic matrix inhibits intramembranous bone healing. J Cell Commun Signal. 2015 Mar;9(1):19-26. doi: 10.1007/s12079-014-0242-x. Epub 2014 Sep 04. PMID: 25186349; PMCID: PMC4414841.
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J Cell Commun Signal. 2015 Mar;9(1):19-26. doi: 10.1007/s12079-014-0242-x. Epub 2014 Sep 04.

Diabetes-induced fibrotic matrix inhibits intramembranous bone healing.

Journal of cell communication and signaling

Roozbeh Khosravi, Philip C Trackman

Affiliations

  1. Department of Molecular and Cell Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, 02118, USA, [email protected].

PMID: 25186349 PMCID: PMC4414841 DOI: 10.1007/s12079-014-0242-x

Abstract

Diabetes diminishes bone healing and ossification. Reduced bone formation in intramembranous ossification is known, yet the mechanism(s) behind impaired intramembranous bone healing are unclear. Here we report the formation of a fibrotic matrix during healing of intramembranous calvarial bone defects that appears to exclude new bone growth. Our histological analyses of 7-day and 14-day calvaria bone healing tissue in chemically-induced diabetic mice and non-diabetic mice showed the accumulation of a non-mineralized fibrotic matrix, likely as a consequence of unresolved hematomas under diabetic conditions. Elevated mRNA and enzyme activity levels of lysyl oxidase on day 7 in diabetic bone healing tissues also supports that the formation of a fibrotic matrix occurs in these tissues. Based on these findings, we propose that elevated fibroblast proliferation and formation of a non-mineralized fibrotic extracellular matrix in diabetes contributes to deficient intramembranous bone healing in diabetes. A greater understanding of this process has relevance to managing dental procedures in diabetics in which successful outcomes depend on intramembranous bone formation.

References

  1. J Biol Chem. 1995 Dec 22;270(51):30797-803 - PubMed
  2. Diabetes. 1990 Apr;39(4):477-82 - PubMed
  3. Cell. 1997 May 30;89(5):677-80 - PubMed
  4. Science. 1976 Jul 30;193(4251):415-7 - PubMed
  5. J Biol Chem. 2007 Sep 14;282(37):27298-27305 - PubMed
  6. J Cell Biochem. 2007 Dec 15;102(6):1343-57 - PubMed
  7. Bone. 2010 Aug;47(2):281-94 - PubMed
  8. Bone. 2008 Nov;43(5):832-9 - PubMed
  9. Horm Metab Res. 2007 Dec;39(12):871-5 - PubMed
  10. Anal Biochem. 2002 Jan 15;300(2):245-51 - PubMed
  11. J Bone Miner Res. 2010 Jul;25(7):1680-94 - PubMed
  12. Cell. 1997 May 30;89(5):755-64 - PubMed
  13. J Clin Invest. 2000 Apr;105(8):1117-24 - PubMed
  14. Am J Respir Cell Mol Biol. 1994 Dec;11(6):751-5 - PubMed
  15. Med Res Rev. 2003 Mar;23(2):117-45 - PubMed
  16. Biochem Biophys Res Commun. 2004 Jan 30;314(1):197-207 - PubMed
  17. Bone. 2014 Jan;58:33-41 - PubMed
  18. Cell. 1997 May 30;89(5):765-71 - PubMed
  19. J Bone Miner Res. 2010 Jul;25(7):1604-15 - PubMed
  20. Bonekey Rep. 2013 Jan 09;2:255 - PubMed
  21. Diabetologia. 2010 Feb;53(2):378-88 - PubMed
  22. Proc Natl Acad Sci U S A. 1977 Jun;74(6):2485-9 - PubMed
  23. Diabetes. 2003 Jun;52(6):1502-10 - PubMed
  24. Acta Trop. 2000 Oct 23;77(1):147-52 - PubMed
  25. Drug News Perspect. 2008 May;21(4):218-24 - PubMed
  26. Int J Biochem Cell Biol. 1996 Dec;28(12):1297-310 - PubMed
  27. Clin Orthop Relat Res. 1994 Nov;(308):220-8 - PubMed
  28. Calcif Tissue Int. 1991 Sep;49(3):155-60 - PubMed

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