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Moradkhani S, Kobarfard F, Ayatollahi SA. Phytochemical Investigations on Chemical Constituents of Achillea tenuifolia Lam. Iran J Pharm Res. 2014;13(3):1049-54
Moradkhani, S., Kobarfard, F., & Ayatollahi, S. A. (2014). Phytochemical Investigations on Chemical Constituents of Achillea tenuifolia Lam. Iranian journal of pharmaceutical research : IJPR, 13(3), 1049-54.
Moradkhani, Shirin, et al. "Phytochemical Investigations on Chemical Constituents of Achillea tenuifolia Lam." Iranian journal of pharmaceutical research : IJPR vol. 13,3 (2014): 1049-54.
Moradkhani S, Kobarfard F, Ayatollahi SA. Phytochemical Investigations on Chemical Constituents of Achillea tenuifolia Lam. Iran J Pharm Res. 2014;13(3):1049-54. PMID: 25276207; PMCID: PMC4177627.
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Iran J Pharm Res. 2014;13(3):1049-54.

Phytochemical Investigations on Chemical Constituents of Achillea tenuifolia Lam.

Iranian journal of pharmaceutical research : IJPR

Shirin Moradkhani, Farzad Kobarfard, Seyed Abdol Majid Ayatollahi

Affiliations

  1. Department of Pharmacognosy and Biotechnology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.
  2. Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ; Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  3. Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ; Department of Pharmacognosy and Biotechnolgy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

PMID: 25276207 PMCID: PMC4177627

Abstract

Achillea tenuifolia Lam. (Asteraceae) afforded a methanolic extract from which after fractionation in solvents with different polarities, two known flavones 3', 5- dihydroxy- 4', 6, 7- trimethoxy flavone (eupatorine, compound 3), 5- hydroxy- 3',4', 6, 7- tetramethoxyflavone (compound 4), besides stearic acid (compound 1), lupeol (compound 2), daucosterol (β- sitosterol 3-O- β- D- glucopyranoside, compound 5), 2, 4- dihydroxy methyl benzoate (compound 6) were isolated for the first time. The structure of isolated compounds was elucidated by means of different spectroscopic methods such as UV, IR, Mass and 1H- NMR (1D and 2D) and 13C-NMR. For further confirming the structures of isolated compounds, comparison of the spectral data of them with those reported in the litratures have been done.

Keywords: Achillea tenuifolia; Asteraceae; Daucosterol; Eupatorine; Lupeol

References

  1. Z Naturforsch C J Biosci. 2002 Nov-Dec;57(11-12):1016-21 - PubMed
  2. Phytochemistry. 2006 May;67(9):887-93 - PubMed
  3. Evid Based Complement Alternat Med. 2007 Mar;4(1):95-8 - PubMed
  4. Iran J Pharm Res. 2012 Winter;11(1):177-83 - PubMed

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