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Gentry LR, Martin TD, Reiner DJ, et al. Ral small GTPase signaling and oncogenesis: More than just 15minutes of fame. Biochim Biophys Acta. 2014;1843(12):2976-2988doi: 10.1016/j.bbamcr.2014.09.004.
Gentry, L. R., Martin, T. D., Reiner, D. J., & Der, C. J. (2014). Ral small GTPase signaling and oncogenesis: More than just 15minutes of fame. Biochimica et biophysica acta, 1843(12), 2976-2988. https://doi.org/10.1016/j.bbamcr.2014.09.004
Gentry, Leanna R, et al. "Ral small GTPase signaling and oncogenesis: More than just 15minutes of fame." Biochimica et biophysica acta vol. 1843,12 (2014): 2976-2988. doi: https://doi.org/10.1016/j.bbamcr.2014.09.004
Gentry LR, Martin TD, Reiner DJ, Der CJ. Ral small GTPase signaling and oncogenesis: More than just 15minutes of fame. Biochim Biophys Acta. 2014 Dec;1843(12):2976-2988. doi: 10.1016/j.bbamcr.2014.09.004. Epub 2014 Sep 16. PMID: 25219551; PMCID: PMC4201770.
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Biochim Biophys Acta. 2014 Dec;1843(12):2976-2988. doi: 10.1016/j.bbamcr.2014.09.004. Epub 2014 Sep 16.

Ral small GTPase signaling and oncogenesis: More than just 15minutes of fame.

Biochimica et biophysica acta

Leanna R Gentry, Timothy D Martin, David J Reiner, Channing J Der

Affiliations

  1. University of North Carolina at Chapel Hill, Department of Pharmacology, Chapel Hill, NC, USA.
  2. Department of Genetics, Harvard Medical School, Boston, MA, USA.
  3. Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX, USA.
  4. University of North Carolina at Chapel Hill, Department of Pharmacology, Chapel Hill, NC, USA; University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USA. Electronic address: [email protected].

PMID: 25219551 PMCID: PMC4201770 DOI: 10.1016/j.bbamcr.2014.09.004

Abstract

Since their discovery in 1986, Ral (Ras-like) GTPases have emerged as critical regulators of diverse cellular functions. Ral-selective guanine nucleotide exchange factors (RalGEFs) function as downstream effectors of the Ras oncoprotein, and the RalGEF-Ral signaling network comprises the third best characterized effector of Ras-dependent human oncogenesis. Because of this, Ral GTPases as well as their effectors are being explored as possible therapeutic targets in the treatment of RAS mutant cancer. The two Ral isoforms, RalA and RalB, interact with a variety of downstream effectors and have been found to play key and distinct roles in both normal and neoplastic cell physiology including regulation of vesicular trafficking, migration and invasion, tumor formation, metastasis, and gene expression. In this review we provide an overview of Ral biochemistry and biology, and we highlight recent discoveries.

Copyright © 2014 Elsevier B.V. All rights reserved.

Keywords: Exocyst; GTPase activating protein; Guanine nucleotide exchange factor; Ras; Rho; Small GTPase

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