Display options
Cite
Bohlson SS, O'Conner SD, Hulsebus HJ, et al. Complement, c1q, and c1q-related molecules regulate macrophage polarization. Front Immunol. 2014;5:402doi: 10.3389/fimmu.2014.00402.
Bohlson, S. S., O'Conner, S. D., Hulsebus, H. J., Ho, M. M., & Fraser, D. A. (2014). Complement, c1q, and c1q-related molecules regulate macrophage polarization. Frontiers in immunology, 5402. https://doi.org/10.3389/fimmu.2014.00402
Bohlson, Suzanne S, et al. "Complement, c1q, and c1q-related molecules regulate macrophage polarization." Frontiers in immunology vol. 5 (2014): 402. doi: https://doi.org/10.3389/fimmu.2014.00402
Bohlson SS, O'Conner SD, Hulsebus HJ, Ho MM, Fraser DA. Complement, c1q, and c1q-related molecules regulate macrophage polarization. Front Immunol. 2014 Aug 21;5:402. doi: 10.3389/fimmu.2014.00402. eCollection 2014. PMID: 25191325; PMCID: PMC4139736.
Copy Download .nbib Format: NLM
Share it on

Front Immunol. 2014 Aug 21;5:402. doi: 10.3389/fimmu.2014.00402. eCollection 2014.

Complement, c1q, and c1q-related molecules regulate macrophage polarization.

Frontiers in immunology

Suzanne S Bohlson, Sean D O'Conner, Holly Jo Hulsebus, Minh-Minh Ho, Deborah A Fraser

Affiliations

  1. Department of Microbiology and Immunology, Des Moines University , Des Moines, IA , USA.
  2. Department of Biologicial Sciences, California State University Long Beach , Long Beach, CA , USA.

PMID: 25191325 PMCID: PMC4139736 DOI: 10.3389/fimmu.2014.00402

Abstract

Complement is a critical system of enzymes, regulatory proteins, and receptors that regulates both innate and adaptive immune responses. Natural mutations in complement molecules highlight their requirement in regulation of a variety of human conditions including infectious disease and autoimmunity. As sentinels of the immune system, macrophages are specialized to respond to infectious microbes, as well as normal and altered self, and dictate appropriate immune responses. Complement components such as anaphylatoxins (C3a and C5a) and opsonins [C3b, C1q, mannan binding lectin (MBL)] influence macrophage responses. While anaphylatoxins C3a and C5a trigger inflammasome activation, opsonins such as C1q and related molecules (MBL and adiponectin) downregulate inflammasome activation and inflammation, and upregulate engulfment of apoptotic cells consistent with a pro-resolving or M2 macrophage phenotype. This review summarizes our current understanding of the influence of the complement system on macrophage polarization with an emphasis on C1q and related molecules.

Keywords: C1q; adiponectin; complement; cytokine; efferocytosis; inflammasome; macrophage; phagocytosis

References

  1. Nature. 2003 Jun 12;423(6941):762-9 - PubMed
  2. J Immunol. 2014 Mar 15;192(6):2837-45 - PubMed
  3. Br J Pharmacol. 2007 Oct;152(4):429-48 - PubMed
  4. Immunol Rev. 2001 Apr;180:112-22 - PubMed
  5. Arthritis Rheum. 2009 Oct;60(10):3081-90 - PubMed
  6. Blood. 2009 Jul 30;114(5):1005-15 - PubMed
  7. Inflamm Res. 2014 Oct;63(10):885-93 - PubMed
  8. J Immunol. 2009 Nov 15;183(10):6175-85 - PubMed
  9. Immunity. 1997 Sep;7(3):345-55 - PubMed
  10. J Immunol. 2012 Apr 15;188(8):3716-23 - PubMed
  11. Mol Immunol. 2011 Aug;48(14):1643-55 - PubMed
  12. Mol Immunol. 2013 Aug;55(1):22-6 - PubMed
  13. Immunology. 1999 May;97(1):166-72 - PubMed
  14. J Neurochem. 2010 Feb;112(3):733-43 - PubMed
  15. Nat Med. 2007 Mar;13(3):332-9 - PubMed
  16. J Neurosci Res. 1990 Sep;27(1):36-42 - PubMed
  17. J Immunol. 2010 Oct 15;185(8):4738-49 - PubMed
  18. Cell Metab. 2011 Apr 6;13(4):401-412 - PubMed
  19. J Clin Invest. 1998 Feb 15;101(4):890-8 - PubMed
  20. J Leukoc Biol. 2012 Sep;92(3):489-97 - PubMed
  21. J Biol Chem. 2003 Mar 28;278(13):11123-9 - PubMed
  22. PLoS Pathog. 2013 Jan;9(1):e1003114 - PubMed
  23. J Immunol. 1987 Feb 15;138(4):1150-6 - PubMed
  24. J Immunol. 2008 Jul 1;181(1):364-73 - PubMed
  25. FEMS Microbiol Lett. 2005 May 15;246(2):221-8 - PubMed
  26. Mol Immunol. 2005 Jul;42(11):1405-15 - PubMed
  27. Nature. 1991 Feb 14;349(6310):614-7 - PubMed
  28. J Mol Biol. 2011 Apr 29;408(2):277-90 - PubMed
  29. Mol Immunol. 2007 Feb;44(6):1169-77 - PubMed
  30. J Exp Med. 1985 Mar 1;161(3):617-22 - PubMed
  31. Curr Drug Targets. 2008 Feb;9(2):113-22 - PubMed
  32. Blood. 2000 Sep 1;96(5):1723-32 - PubMed
  33. Clin Exp Immunol. 2009 May;156(2):303-11 - PubMed
  34. F1000Prime Rep. 2014 Mar 03;6:13 - PubMed
  35. Mol Immunol. 2009 Sep;46(14):2753-66 - PubMed
  36. Immunobiology. 1998 Aug;199(2):265-85 - PubMed
  37. Trends Endocrinol Metab. 2012 Apr;23(4):194-204 - PubMed
  38. J Immunol. 2003 Mar 15;170(6):3306-14 - PubMed
  39. J Immunol. 2012 Jun 1;188(11):5682-93 - PubMed
  40. J Exp Med. 2000 Aug 7;192(3):359-66 - PubMed
  41. J Innate Immun. 2014;6(6):780-92 - PubMed
  42. Endocr Rev. 2005 May;26(3):439-51 - PubMed
  43. J Biol Chem. 2002 Mar 1;277(9):7165-9 - PubMed
  44. J Immunol. 2009 Jul 15;183(2):1375-83 - PubMed
  45. J Immunol. 2008 Dec 15;181(12):8633-41 - PubMed
  46. Ann Rheum Dis. 2014 Sep;73(9):1601-6 - PubMed
  47. J Immunol. 2013 Aug 1;191(3):1006-10 - PubMed
  48. J Exp Med. 1998 Dec 21;188(12):2313-20 - PubMed
  49. Cell Metab. 2013 Aug 6;18(2):251-64 - PubMed
  50. Biochemistry. 2003 Aug 12;42(31):9406-15 - PubMed
  51. Mol Immunol. 2011 Aug;48(14):1592-603 - PubMed
  52. Lupus. 2013 Jun;22(7):657-63 - PubMed
  53. Biol Chem. 2010 Sep;391(9):1005-18 - PubMed
  54. Crit Rev Immunol. 2012;32(6):463-88 - PubMed
  55. Cell. 2006 Mar 10;124(5):915-27 - PubMed
  56. J Neuroimmunol. 2000 Sep 22;109(2):87-94 - PubMed
  57. Infect Immun. 2001 Dec;69(12):7729-35 - PubMed
  58. J Biol Chem. 2013 Sep 6;288(36):26013-26026 - PubMed
  59. Front Immunol. 2013 Jan 09;3:387 - PubMed
  60. J Immunol. 1997 May 15;158(10):4525-8 - PubMed
  61. J Exp Med. 1983 Dec 1;158(6):2016-23 - PubMed
  62. J Exp Med. 1994 Jun 1;179(6):1809-21 - PubMed
  63. J Immunol. 1994 May 15;152(10):5050-9 - PubMed
  64. J Immunol. 2010 Oct 1;185(7):3932-9 - PubMed
  65. Am J Pathol. 2007 Jan;170(1):416-26 - PubMed
  66. Mol Immunol. 2014 Oct;61(2):135-48 - PubMed
  67. J Biol Chem. 1996 Aug 23;271(34):20231-4 - PubMed
  68. Blood. 2013 Nov 14;122(20):3473-81 - PubMed
  69. J Exp Med. 2001 Sep 17;194(6):781-95 - PubMed
  70. J Leukoc Biol. 2006 Jul;80(1):107-16 - PubMed
  71. Eur J Immunol. 1991 Feb;21(2):431-7 - PubMed
  72. J Biol Chem. 2007 Mar 9;282(10):7360-7 - PubMed
  73. Biochim Biophys Acta. 2002 Apr 12;1574(3):387-90 - PubMed
  74. Biomed Res Int. 2014;2014:616817 - PubMed
  75. Br J Pharmacol. 2009 Jul;157(6):922-30 - PubMed
  76. Immunobiology. 2007;212(4-5):253-66 - PubMed
  77. Crit Rev Immunol. 2001;21(5):399-425 - PubMed
  78. Immunobiology. 2002 Sep;205(4-5):395-406 - PubMed
  79. Cytokine Growth Factor Rev. 2008 Feb;19(1):41-52 - PubMed
  80. J Immunol. 2009 Jan 15;182(2):1192-201 - PubMed
  81. Arthritis Rheum. 2007 May;56(5):1598-607 - PubMed
  82. J Immunol. 2012 Jan 15;188(2):902-15 - PubMed

Publication Types

Grant support