Display options
Cite
Shimura N, Kojima S. Effects of low-dose-gamma rays on the immune system of different animal models of disease. Dose Response. 2014;12(3):429-65doi: 10.2203/dose-response.13-042.Shimura.
Shimura, N., & Kojima, S. (2014). Effects of low-dose-gamma rays on the immune system of different animal models of disease. Dose-response : a publication of International Hormesis Society, 12(3), 429-65. https://doi.org/10.2203/dose-response.13-042.Shimura
Shimura, Noriko, and Kojima, Shuji. "Effects of low-dose-gamma rays on the immune system of different animal models of disease." Dose-response : a publication of International Hormesis Society vol. 12,3 (2014): 429-65. doi: https://doi.org/10.2203/dose-response.13-042.Shimura
Shimura N, Kojima S. Effects of low-dose-gamma rays on the immune system of different animal models of disease. Dose Response. 2014 Apr 23;12(3):429-65. doi: 10.2203/dose-response.13-042.Shimura. eCollection 2014 Jul. PMID: 25249835; PMCID: PMC4146334.
Copy Download .nbib Format: NLM
Share it on

Dose Response. 2014 Apr 23;12(3):429-65. doi: 10.2203/dose-response.13-042.Shimura. eCollection 2014 Jul.

Effects of low-dose-gamma rays on the immune system of different animal models of disease.

Dose-response : a publication of International Hormesis Society

Noriko Shimura, Shuji Kojima

Affiliations

  1. Faculty of Pharmaceutical Sciences, Ohu University, Japan.
  2. Faculty of Pharmaceutical Sciences, Tokyo University of Science, Japan.

PMID: 25249835 PMCID: PMC4146334 DOI: 10.2203/dose-response.13-042.Shimura

Abstract

We reviewed the beneficial or harmful effects of low-dose ionizing radiation on several diseases based on a search of the literature. The attenuation of autoimmune manifestations in animal disease models irradiated with low-dose γ-rays was previously reported by several research groups, whereas the exacerbation of allergic manifestations was described by others. Based on a detailed examination of the literature, we divided animal disease models into two groups: one group consisting of collagen-induced arthritis (CIA), experimental encephalomyelitis (EAE), and systemic lupus erythematosus, the pathologies of which were attenuated by low-dose irradiation, and another group consisting of atopic dermatitis, asthma, and Hashimoto's thyroiditis, the pathologies of which were exacerbated by low-dose irradiation. The same biological indicators, such as cytokine levels and T-cell subpopulations, were examined in these studies. Low-dose irradiation reduced inter-feron (IFN)-gamma (γ) and interleukin (IL)-6 levels and increased IL-5 levels and the percentage of CD4(+)CD25(+)Foxp3(+)Treg cells in almost all immunological disease cases examined. Variations in these biological indicators were attributed to the attenuation or exacerbation of the disease's manifestation. We concluded that autoimmune diseases caused by autoantibodies were attenuated by low-dose irradiation, whereas diseases caused by antibodies against external antigens, such as atopic dermatitis, were exacerbated.

Keywords: T-cell subpopulation; allergic diseases; autoimmune disease; cytokines; immune response; low-dose irradiation

References

  1. Immunol Cell Biol. 1996 Jun;74(3):274-7 - PubMed
  2. Exp Gerontol. 1975 Aug;10(3-4):189-93 - PubMed
  3. Clin Immunol Immunopathol. 1990 Jun;55(3):427-37 - PubMed
  4. Arthritis Res Ther. 2005;7(1):29-37 - PubMed
  5. Rheumatol Int. 2013 Mar;33(3):697-703 - PubMed
  6. Scand J Immunol. 2008 Dec;68(6):589-97 - PubMed
  7. Jpn J Pharmacol. 2002 Dec;90(4):328-36 - PubMed
  8. Immunol Lett. 1999 Jun 1;68(2-3):237-45 - PubMed
  9. Exp Clin Endocrinol Diabetes. 1996;104 Suppl 3:17-20 - PubMed
  10. J Radiat Res. 1990 Sep;31(3):256-62 - PubMed
  11. Acta Otolaryngol. 1976 Sep-Oct;82(3-4):204-7 - PubMed
  12. Ann Med. 1991 Aug;23(3):219-23 - PubMed
  13. Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3915-20 - PubMed
  14. Ann N Y Acad Sci. 1996 Oct 31;796:91-6 - PubMed
  15. J Exp Med. 1984 Jan 1;159(1):1-20 - PubMed
  16. J Allergy Clin Immunol. 1997 May;99(5):673-82 - PubMed
  17. Clin Exp Pharmacol Physiol. 2006 May-Jun;33(5-6):519-24 - PubMed
  18. J Asthma. 1997;34(3):195-201 - PubMed
  19. Radiat Res. 1999 Jun;151(6):717-24 - PubMed
  20. Physiol Chem Phys Med NMR. 1996;28(1):7-14 - PubMed
  21. J Radiat Res. 2003 Sep;44(3):243-7 - PubMed
  22. CNS Neurol Disord Drug Targets. 2012 Aug;11(5):506-17 - PubMed
  23. Int J Radiat Biol. 2000 Dec;76(12):1641-7 - PubMed
  24. Int J Radiat Biol. 2003 Dec;79(12):993-1001 - PubMed
  25. Mamm Genome. 1992;2(3):158-71 - PubMed
  26. Radiat Res. 2008 Jan;169(1):59-66 - PubMed
  27. Nature. 2003 May 15;423(6937):356-61 - PubMed
  28. Radiat Res. 1999 Sep;152(3):273-9 - PubMed
  29. Inflamm Res. 2013 Jan;62(1):27-36 - PubMed
  30. J Immunol. 1987 Oct 1;139(7):2200-10 - PubMed
  31. Health Phys. 1982 Dec;43(6):771-89 - PubMed
  32. J Radiat Res. 1994 Jun;35(2):83-91 - PubMed
  33. Int J Radiat Biol Relat Stud Phys Chem Med. 1988 Jan;53(1):103-18 - PubMed
  34. J Immunol. 1990 May 1;144(9):3347-53 - PubMed
  35. Arthritis Rheum. 2006 Jul;54(7):2198-210 - PubMed
  36. Clin Exp Immunol. 2007 Apr;148(1):32-46 - PubMed
  37. Am J Respir Crit Care Med. 1997 Oct;156(4 Pt 2):S78-81 - PubMed
  38. Nat Immunol. 2005 Apr;6(4):345-52 - PubMed
  39. Am J Respir Cell Mol Biol. 1996 Apr;14(4):319-26 - PubMed
  40. Chin Med J (Engl). 1996 Mar;109(3):215-8 - PubMed
  41. J Neuropsychiatry Clin Neurosci. 2011 Fall;23(4):442-8 - PubMed
  42. Radiat Res. 2000 Dec;154(6):680-5 - PubMed
  43. Radiat Res. 2013 May;179(5):570-83 - PubMed
  44. J Clin Invest. 1999 Apr;103(8):1103-11 - PubMed
  45. Clin Exp Immunol. 1984 Nov;58(2):348-56 - PubMed
  46. Ann Rheum Dis. 2010 Aug;69(8):1519-26 - PubMed
  47. Radiat Environ Biophys. 2008 Apr;47(2):275-83 - PubMed
  48. Arthritis Rheum. 2007 Dec;56(12):4015-23 - PubMed
  49. Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5150-5 - PubMed
  50. Int J Radiat Biol. 2005 Oct;81(10):731-40 - PubMed
  51. Clin Exp Allergy. 1995 Jun;25(6):515-21 - PubMed
  52. Lancet. 1998 Sep 5;352(9130):763-6 - PubMed
  53. Immunol Suppl. 1988;1:51-2 - PubMed
  54. Annu Rev Immunol. 1991;9:243-69 - PubMed
  55. Transplant Proc. 2008 Dec;40(10 Suppl):S13-6 - PubMed
  56. J Radiat Res. 2005 Jun;46(2):151-6 - PubMed
  57. J Invest Dermatol. 1994 Oct;103(4):589-92 - PubMed
  58. J Clin Invest. 1996 Apr 1;97(7):1748-60 - PubMed
  59. J Allergy Clin Immunol. 1998 May;101(5):699-708 - PubMed
  60. Am J Respir Cell Mol Biol. 1996 May;14(5):439-43 - PubMed
  61. J Clin Lab Immunol. 1999;51(1):9-20 - PubMed
  62. Ann Hematol. 2011 Jun;90(6):617-24 - PubMed
  63. Int Arch Allergy Immunol. 2001 Nov;126(3):239-47 - PubMed
  64. Clin Exp Allergy. 2001 Aug;31(8):1232-41 - PubMed
  65. Ann Intern Med. 1994 Nov 1;121(9):698-708 - PubMed
  66. Cell. 1996 May 3;85(3):307-10 - PubMed
  67. Am J Respir Cell Mol Biol. 1994 May;10(5):471-80 - PubMed
  68. Acta Derm Venereol Suppl (Stockh). 1989;151:77-83; discussion 106-10 - PubMed
  69. Autoimmun Rev. 2007 Nov;7(1):65-70 - PubMed
  70. Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16246-51 - PubMed
  71. Brain Res Rev. 2011 Jun 24;67(1-2):157-83 - PubMed
  72. Clin Exp Allergy. 1994 Jan;24(1):73-80 - PubMed
  73. Ann Immunol (Paris). 1983 Jan-Feb;134C(1):149-57 - PubMed
  74. Autoimmunity. 2009 May;42(4):337-9 - PubMed
  75. Int J Radiat Biol. 2000 Aug;76(8):1143-53 - PubMed
  76. Mol Genet Metab. 1998 Mar;63(3):157-67 - PubMed
  77. Ann Rheum Dis. 1990 Sep;49(9):676-81 - PubMed
  78. Curr Med Chem. 2012;19(12):1741-50 - PubMed
  79. Mod Rheumatol. 2008;18(5):429-41 - PubMed
  80. Strahlenther Onkol. 2004 Mar;180(3):165-72 - PubMed
  81. Clin Immunol Immunopathol. 1985 Nov;37(2):220-9 - PubMed
  82. J Neuroimmunol. 2012 Aug 15;249(1-2):109-11 - PubMed
  83. Arch Dis Child. 1977 Dec;52(12):951-5 - PubMed
  84. Chin Med J (Engl). 1989 Oct;102(10):750-5 - PubMed
  85. J Endocrinol Invest. 2008 Oct;31(10):861-5 - PubMed
  86. Health Phys. 1987 May;52(5):579-83 - PubMed
  87. Clin Lab. 2012;58(3-4):253-60 - PubMed
  88. J Dermatol. 2001 May;28(5):237-43 - PubMed
  89. Exp Biol Med (Maywood). 2004 Jan;229(1):12-20 - PubMed
  90. J Exp Med. 1996 Apr 1;183(4):1447-59 - PubMed
  91. Ann Surg. 1955 May;141(5):737-46 - PubMed
  92. Int J Radiat Biol. 2005 Oct;81(10):721-9 - PubMed
  93. Curr Opin Immunol. 1993 Dec;5(6):956-62 - PubMed
  94. Radiat Res. 2002 Mar;157(3):275-80 - PubMed
  95. Blood. 1989 Jul;74(1):1-10 - PubMed
  96. Exp Neurol. 2012 Oct;237(2):296-303 - PubMed
  97. Int J Radiat Biol. 2007 Jun;83(6):357-66 - PubMed
  98. J Exp Med. 1993 Aug 1;178(2):723-30 - PubMed
  99. Clin Immunol Immunopathol. 1997 Sep;84(3):251-9 - PubMed
  100. J Exp Med. 2004 Apr 5;199(7):971-9 - PubMed
  101. Am J Physiol. 1996 Sep;271(3 Pt 1):L476-83 - PubMed
  102. Arthritis Rheum. 1991 Sep;34(9):1125-32 - PubMed
  103. Radiat Res. 2003 Mar;159(3):320-7 - PubMed
  104. Physiol Chem Phys Med NMR. 1995;27(1):17-23 - PubMed
  105. Int J Radiat Biol. 2008 Sep;84(9):761-9 - PubMed
  106. J Exp Med. 1996 Jan 1;183(1):195-201 - PubMed
  107. Int J Radiat Biol. 2005 Nov;81(11):801-12 - PubMed
  108. Eur J Immunol. 2010 Jul;40(7):1830-5 - PubMed
  109. Am J Respir Crit Care Med. 1997 Sep;156(3 Pt 1):704-8 - PubMed
  110. Arthritis Rheum. 2003 May;48(5):1452-60 - PubMed
  111. Med Sci Monit. 2001 Sep-Oct;7(5):914-8 - PubMed
  112. Proc Natl Acad Sci U S A. 1992 Mar 1;89(5):1890-3 - PubMed
  113. Int J Radiat Biol Relat Stud Phys Chem Med. 1988 Jan;53(1):137-52 - PubMed
  114. Ann Rheum Dis. 2002 Nov;61 Suppl 2:ii84-6 - PubMed
  115. Vojnosanit Pregl. 2012 Feb;69(2):151-6 - PubMed
  116. J Clin Lab Immunol. 1991 Mar;34(3):107-13 - PubMed
  117. J Am Acad Dermatol. 1982 Jan;6(1):1-13 - PubMed
  118. J Dermatol Sci. 1992 May;3(3):172-80 - PubMed
  119. Int J Radiat Oncol Biol Phys. 1997 Aug 1;39(1):161-71 - PubMed
  120. Nature. 1986 Nov 20-26;324(6094):258-60 - PubMed
  121. J Immunol. 2006 Apr 1;176(7):4484-91 - PubMed
  122. J Radiat Res. 2007 Jan;48(1):51-5 - PubMed
  123. Calif Med. 1972 May;116(5):25-33 - PubMed
  124. J Rheumatol. 1990 Dec;17(12):1608-12 - PubMed
  125. J Clin Neurosci. 2011 Oct;18(10):1313-7 - PubMed
  126. Life Sci. 1997;61(19):1861-78 - PubMed
  127. Nature. 1992 Mar 26;356(6367):314-7 - PubMed
  128. Allergol Int. 2008 Jun;57(2):115-20 - PubMed
  129. Acta Reumatol Port. 2008 Jan-Mar;33(1):17-33 - PubMed
  130. Anticancer Res. 2000 May-Jun;20(3A):1583-8 - PubMed
  131. J Immunol. 2003 Dec 1;171(11):6173-7 - PubMed
  132. Radiat Res. 2010 Oct;174(4):480-9 - PubMed
  133. J Radiat Res. 2004 Mar;45(1):33-9 - PubMed
  134. Phys Med Biol. 2003 Jul 7;48(13):2041-9 - PubMed
  135. Radiat Res. 2010 Sep;174(3):313-24 - PubMed
  136. Arthritis Rheum. 2005 Jul;52(7):2212-21 - PubMed
  137. Clin Immunol Immunopathol. 1996 Dec;81(3):287-92 - PubMed
  138. J Allergy Clin Immunol. 1996 May;97(5):1121-8 - PubMed
  139. Ann Allergy. 1983 Jan;50(1):51-4 - PubMed
  140. J Investig Allergol Clin Immunol. 2011;21(3):199-206 - PubMed
  141. Radiat Res. 2008 Oct;170(4):429-36 - PubMed
  142. N Engl J Med. 1992 Jan 30;326(5):298-304 - PubMed
  143. J Allergy Clin Immunol. 1992 Sep;90(3 Pt 1):323-31 - PubMed
  144. J Radiat Res. 2008 Jul;49(4):381-9 - PubMed

Publication Types