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Pedram M, Vafaie M, Fekri K, et al. Cerebellar neuroblastoma in 2.5 years old child. Iran J Cancer Prev. 2013;6(3):174-6
Pedram, M., Vafaie, M., Fekri, K., Haghi, S., Rashidi, I., & Pirooti, C. (2013). Cerebellar neuroblastoma in 2.5 years old child. Iranian journal of cancer prevention, 6(3), 174-6.
Pedram, Mohammad, et al. "Cerebellar neuroblastoma in 2.5 years old child." Iranian journal of cancer prevention vol. 6,3 (2013): 174-6.
Pedram M, Vafaie M, Fekri K, Haghi S, Rashidi I, Pirooti C. Cerebellar neuroblastoma in 2.5 years old child. Iran J Cancer Prev. 2013;6(3):174-6. PMID: 25250130; PMCID: PMC4142921.
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Iran J Cancer Prev. 2013;6(3):174-6.

Cerebellar neuroblastoma in 2.5 years old child.

Iranian journal of cancer prevention

Mohammad Pedram, Majid Vafaie, Kiavash Fekri, Sabahat Haghi, Iran Rashidi, Chia Pirooti

Affiliations

  1. Thalassemia and Hemoglobinopathy Research Center, Ahvaz Jondishapur University of Medical Sciences, Ahvaz, Iran.
  2. Dept. of Pathology, Shafa Hospital , Ahvaz Jondishapur University of Medical Sciences, Ahvaz, Iran.
  3. Dept. of Neurosurgery, Golestan Hospital, Ahvaz Jondishapur University of Medical Sciences, Ahvaz, Iran.

PMID: 25250130 PMCID: PMC4142921

Abstract

Neuroblastoma is the third most common malignancy of childhood, after leukemia and brain tumors. Only 2% of all neuroblastoma occur in the brain. Primary cerebellar neuroblastoma is an specific subset of Primitive Neuroectodermal Tumors (PNET). Meduloblastoma is a relatively common and well-established entity, consisting of primitive and multipotential cells that may exhibit some evidence of neuroblastic or gliad differentiation. But cerebellar neuroblastoma with ultrastractural evidence of significant neuroblastic differentiation is extremely rare. We report a rare case of neuroblastoma in the cerebellum. A 2.5-year-old Iranian boy presented with vomiting and nausea in the morning and ataxia. CT scan showed a tumor mass in the cerebellum and the report of radiologist was medulloblastoma. Light microscopic assay showed a small cell neoplasm with lobules of densely packed cells (lobulated pattern) and better differentiated cells. Neuron-Specific Enolase was positive. Pathologic diagnosis confirmed the existence of cerebellar neuroblastoma. Chemotherapy followed surgical removal. No relapse occurred 12 months after surgery.

Keywords: Cerebellum; Chemotherapy; Neuroblastoma

References

  1. Cancer. 1981 Feb 15;47(4):772-9 - PubMed
  2. Acta Neuropathol. 1982;56(1):22-8 - PubMed
  3. Acta Neuropathol. 1978 Apr 26;42(1):11-3 - PubMed
  4. Neuropediatrics. 1997 Aug;28(4):235-8 - PubMed
  5. Asian Pac J Cancer Prev. 2008 Apr-Jun;9(2):361-2 - PubMed
  6. JBR-BTR. 2005 May-Jun;88(3):148-9 - PubMed
  7. Turk J Pediatr. 2004 Apr-Jun;46(2):182-5 - PubMed
  8. Asian Pac J Cancer Prev. 2006 Apr-Jun;7(2):283-8 - PubMed
  9. Acta Neuropathol. 1980;50(2):139-42 - PubMed
  10. Clin Neurol Neurosurg. 2000 Mar;102(1):52-7 - PubMed

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