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Saku K, Kishi T, Sakamoto K, et al. Afferent vagal nerve stimulation resets baroreflex neural arc and inhibits sympathetic nerve activity. Physiol Rep. 2014;2(9)doi: 10.14814/phy2.12136.
Saku, K., Kishi, T., Sakamoto, K., Hosokawa, K., Sakamoto, T., Murayama, Y., Kakino, T., Ikeda, M., Ide, T., & Sunagawa, K. (2014). Afferent vagal nerve stimulation resets baroreflex neural arc and inhibits sympathetic nerve activity. Physiological reports, 2(9), . https://doi.org/10.14814/phy2.12136
Saku, Keita, et al. "Afferent vagal nerve stimulation resets baroreflex neural arc and inhibits sympathetic nerve activity." Physiological reports vol. 2,9 (2014). doi: https://doi.org/10.14814/phy2.12136
Saku K, Kishi T, Sakamoto K, Hosokawa K, Sakamoto T, Murayama Y, Kakino T, Ikeda M, Ide T, Sunagawa K. Afferent vagal nerve stimulation resets baroreflex neural arc and inhibits sympathetic nerve activity. Physiol Rep. 2014 Sep 04;2(9). doi: 10.14814/phy2.12136. Print 2014 Sep 01. PMID: 25194023; PMCID: PMC4270242.
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Physiol Rep. 2014 Sep 04;2(9). doi: 10.14814/phy2.12136. Print 2014 Sep 01.

Afferent vagal nerve stimulation resets baroreflex neural arc and inhibits sympathetic nerve activity.

Physiological reports

Keita Saku, Takuya Kishi, Kazuo Sakamoto, Kazuya Hosokawa, Takafumi Sakamoto, Yoshinori Murayama, Takamori Kakino, Masataka Ikeda, Tomomi Ide, Kenji Sunagawa

Affiliations

  1. Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
  2. Department of Advanced Therapeutics for Cardiovascular Diseases, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

PMID: 25194023 PMCID: PMC4270242 DOI: 10.14814/phy2.12136

Abstract

It has been established that vagal nerve stimulation (VNS) benefits patients and/or animals with heart failure. However, the impact of VNS on sympathetic nerve activity (SNA) remains unknown. In this study, we investigated how vagal afferent stimulation (AVNS) impacts baroreflex control of SNA. In 12 anesthetized Sprague-Dawley rats, we controlled the pressure in isolated bilateral carotid sinuses (CSP), and measured splanchnic SNA and arterial pressure (AP). Under a constant CSP, increasing the voltage of AVNS dose dependently decreased SNA and AP. The averaged maximal inhibition of SNA was -28.0 ± 10.3%. To evaluate the dynamic impacts of AVNS on SNA, we performed random AVNS using binary white noise sequences, and identified the transfer function from AVNS to SNA and that from SNA to AP. We also identified transfer functions of the native baroreflex from CSP to SNA (neural arc) and from SNA to AP (peripheral arc). The transfer function from AVNS to SNA strikingly resembled the baroreflex neural arc and the transfer functions of SNA to AP were indistinguishable whether we perturbed ANVS or CSP, indicating that they likely share common central and peripheral neural mechanisms. To examine the impact of AVNS on baroreflex, we changed CSP stepwise and measured SNA and AP responses with or without AVNS. AVNS resets the sigmoidal neural arc downward, but did not affect the linear peripheral arc. In conclusion, AVNS resets the baroreflex neural arc and induces sympathoinhibition in the same manner as the control of SNA and AP by the native baroreflex.

© 2014 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

Keywords: Afferent nerve; carotid sinus baroreflex; sympathetic nerve activity; vagal nerve stimulation

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