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Rigoni A, Colombo MP, Pucillo C. The Role of Mast Cells in Molding the Tumor Microenvironment. Cancer Microenviron. 2014;8(3):167-76doi: 10.1007/s12307-014-0152-8.
Rigoni, A., Colombo, M. P., & Pucillo, C. (2015). The Role of Mast Cells in Molding the Tumor Microenvironment. Cancer microenvironment : official journal of the International Cancer Microenvironment Society, 8(3), 167-76. https://doi.org/10.1007/s12307-014-0152-8
Rigoni, A, et al. "The Role of Mast Cells in Molding the Tumor Microenvironment." Cancer microenvironment : official journal of the International Cancer Microenvironment Society vol. 8,3 (2015): 167-76. doi: https://doi.org/10.1007/s12307-014-0152-8
Rigoni A, Colombo MP, Pucillo C. The Role of Mast Cells in Molding the Tumor Microenvironment. Cancer Microenviron. 2015 Dec;8(3):167-76. doi: 10.1007/s12307-014-0152-8. Epub 2014 Sep 07. PMID: 25194694; PMCID: PMC4715001.
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Cancer Microenviron. 2015 Dec;8(3):167-76. doi: 10.1007/s12307-014-0152-8. Epub 2014 Sep 07.

The Role of Mast Cells in Molding the Tumor Microenvironment.

Cancer microenvironment : official journal of the International Cancer Microenvironment Society

A Rigoni, M P Colombo, C Pucillo

Affiliations

  1. Molecular Immunology Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori, via Amadeo 42, 20133, Milan, Italy.
  2. Molecular Immunology Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori, via Amadeo 42, 20133, Milan, Italy. [email protected].
  3. Department of Medical and Biological Sciences, University of Udine, 33100, Udine, Italy.

PMID: 25194694 PMCID: PMC4715001 DOI: 10.1007/s12307-014-0152-8

Abstract

Mast cells (MCs) are granulocytic immune cells that reside in tissues exposed to the external environment. MCs are best known for their activity in allergic reactions, but they have been involved in different physiological and pathological conditions. In particular, MC infiltration has been shown in several types of human tumors and in animal cancer models. Nevertheless, the role of MCs in the tumor microenvironment is still debated because they have been associated either to good or poor prognosis depending on tumor type and tissue localization. This dichotomous role relies on MC capacity to secrete a broad spectrum of molecules with modulatory functions, which may condition the final tumor outcome also promoting angiogenesis and tissue remodeling. In this review, we analyze the multifaceted role of mast cell in tumor progression and inhibition considering their ability to interact with: i) immune cells, ii) tumor cells and iii) the extracellular matrix. Eventually, the current MC targeting strategies to treat cancer patients are discussed. Deciphering the actual role of MCs in tumor onset and progression is crucial to identify MC-targeted treatments aimed at killing cancer cells or at making the tumor vulnerable to selected anti-cancer drugs.

Keywords: Cancer; Extracellular matrix; Immune responses; Immunosuppression; Mast cell

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