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Photoacoustics. 2014 Sep 01;2(3):119-127. doi: 10.1016/j.pacs.2014.07.001.

Cellulose Nanoparticles are a Biodegradable Photoacoustic Contrast Agent for Use in Living Mice.

Photoacoustics

Jesse V Jokerst, Dominique Van de Sompel, Sarah E Bohndiek, Sanjiv S Gambhir

Affiliations

  1. Molecular Imaging Program at Stanford (MIPS), Department of Radiology, 318 Campus Drive, Stanford University Stanford, CA 94305-5427, .
  2. Molecular Imaging Program at Stanford (MIPS), Department of Radiology, 318 Campus Drive, Stanford University Stanford, CA 94305-5427, , ; Bioengineering, Materials Science & Engineering, Bio-X Stanford University, Stanford, CA 94305.

PMID: 25225633 PMCID: PMC4161983 DOI: 10.1016/j.pacs.2014.07.001

Abstract

Molecular imaging with photoacoustic ultrasound is an emerging field that combines the spatial and temporal resolution of ultrasound with the contrast of optical imaging. However, there are few imaging agents that offer both high signal intensity and biodegradation into small molecules. Here we describe a cellulose-based nanoparticle with peak photoacoustic signal at 700 nm and an

Keywords: Photoacoustic imaging; biodegradable nanoparticle; biodegradation; cellulose; nanoparticle; optoacoustic; ovarian cancer

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