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Immunol Today. 1983 Sep;4(9):247-9. doi: 10.1016/0167-5699(83)90041-5.

On the necessity of the idiotype network: studies with nude mice.

Immunology today

H M Edinger, C H Heusser

Affiliations

  1. Basel Institute for Immunology (founded and supported by F. Hoffmann-La Roche and Co., Ltd, Basel, Switzerland) and Pharmaceutical Research Laboratories, Ciba-Geigy Ltd, Basel, Switzerland.

PMID: 25290300 DOI: 10.1016/0167-5699(83)90041-5

Abstract

jerne suggested that a quintessentialfeature of the immune system was the recognition of self-idiotypes(1,2). Despite intense interest and investigation, the concept remains a hypothesis. Here the authors discuss data which place in question the necessity of an idiotype network.

Copyright © 1983. Published by Elsevier B.V.

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