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Valdimarsson H, Bake BS, Jónsdótdr I, et al. Psoriasis: a disease of abnormal Keratinocyte proliferation induced by T lymphocytes. Immunol Today. 1986;7(9):256-9doi: 10.1016/0167-5699(86)90005-8.
Valdimarsson, H., Bake, B. S., Jónsdótdr, I., & Fry, L. (1986). Psoriasis: a disease of abnormal Keratinocyte proliferation induced by T lymphocytes. Immunology today, 7(9), 256-9. https://doi.org/10.1016/0167-5699(86)90005-8
Valdimarsson, H, et al. "Psoriasis: a disease of abnormal Keratinocyte proliferation induced by T lymphocytes." Immunology today vol. 7,9 (1986): 256-9. doi: https://doi.org/10.1016/0167-5699(86)90005-8
Valdimarsson H, Bake BS, Jónsdótdr I, Fry L. Psoriasis: a disease of abnormal Keratinocyte proliferation induced by T lymphocytes. Immunol Today. 1986 Sep;7(9):256-9. doi: 10.1016/0167-5699(86)90005-8. PMID: 25290627.
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Immunol Today. 1986 Sep;7(9):256-9. doi: 10.1016/0167-5699(86)90005-8.

Psoriasis: a disease of abnormal Keratinocyte proliferation induced by T lymphocytes.

Immunology today

H Valdimarsson, B S Bake, I Jónsdótdr, L Fry

Affiliations

  1. Department of Immunology, Landspitalinn, Reykjavik, Iceland.
  2. Department of Immunology, St. Mary's Hospital, London W2, UK.
  3. Department of Dermatology, St. Mary's Hospital, London W2, UK.

PMID: 25290627 DOI: 10.1016/0167-5699(86)90005-8

Abstract

Psoriasis affects 2% of the population in Western countries. Its aetiology and pathogenesis remain unknown but suggestions include abnormalities of blood vessels, neural components, epidermal cell cycle time or maturation of keratinocytes. More recently autoimmune reactions have been implicated involving stratum corneum antibodies(1) and antibodies to nuclei of basal epidermal cells(2). However, there is no convincing evidence that any of these abnormalities are of primary nature. In this article, Helgi Valdimarsson and his colleagues propose that the process leading to psoriatic lesions is triggered by T lymphocytes within the epidermal compartment. They envisage that psoratic lesions erupt where epidermal influx of antigen-carrying Langerhans cells and helper T lymphocytes overrides the normal epidermal suppressor mechanism.

Copyright © 1986. Published by Elsevier B.V.

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