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Dembić Z, von Boehmer H, Steinmetz M. The role of T-cell receptor α and β genes in MHC-restricted antigen recognition. Immunol Today. 1986;7(10):308-11doi: 10.1016/0167-5699(86)90068-X.
Dembić, Z., von Boehmer, H., & Steinmetz, M. (1986). The role of T-cell receptor α and β genes in MHC-restricted antigen recognition. Immunology today, 7(10), 308-11. https://doi.org/10.1016/0167-5699(86)90068-X
Dembić, Z, et al. "The role of T-cell receptor α and β genes in MHC-restricted antigen recognition." Immunology today vol. 7,10 (1986): 308-11. doi: https://doi.org/10.1016/0167-5699(86)90068-X
Dembić Z, von Boehmer H, Steinmetz M. The role of T-cell receptor α and β genes in MHC-restricted antigen recognition. Immunol Today. 1986 Oct;7(10):308-11. doi: 10.1016/0167-5699(86)90068-X. PMID: 25290849.
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Immunol Today. 1986 Oct;7(10):308-11. doi: 10.1016/0167-5699(86)90068-X.

The role of T-cell receptor α and β genes in MHC-restricted antigen recognition.

Immunology today

Z Dembić, H von Boehmer, M Steinmetz

Affiliations

  1. Basel Institute for Immunology, Basel, Switzerland.

PMID: 25290849 DOI: 10.1016/0167-5699(86)90068-X

Abstract

T cells use α- and β-chain genes, which are organized and diversified by somatic DNA rearrangements much like the immunoglobulin genes, to encode clonally distributed receptor molecules which confer specificity for MHC and antigen. Here Zlatko Dembic and his colleagues summarize recent mutagenesis and gene transfection experiments indicating that α- and β-chain genes are necessary and sufficient for T-cell specificity.

Copyright © 1986. Published by Elsevier B.V.

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