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Casalino G, Querques G, Corvi F, et al. Choroidal neovascularization in a patient with Crohn's disease. Case Rep Ophthalmol. 2014;5(2):249-54doi: 10.1159/000365881.
Casalino, G., Querques, G., Corvi, F., Borrelli, E., Triolo, G., Ramirez, G. A., & Bandello, F. (2014). Choroidal neovascularization in a patient with Crohn's disease. Case reports in ophthalmology, 5(2), 249-54. https://doi.org/10.1159/000365881
Casalino, Giuseppe, et al. "Choroidal neovascularization in a patient with Crohn's disease." Case reports in ophthalmology vol. 5,2 (2014): 249-54. doi: https://doi.org/10.1159/000365881
Casalino G, Querques G, Corvi F, Borrelli E, Triolo G, Ramirez GA, Bandello F. Choroidal neovascularization in a patient with Crohn's disease. Case Rep Ophthalmol. 2014 Aug 04;5(2):249-54. doi: 10.1159/000365881. eCollection 2014 May. PMID: 25232338; PMCID: PMC4163694.
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Case Rep Ophthalmol. 2014 Aug 04;5(2):249-54. doi: 10.1159/000365881. eCollection 2014 May.

Choroidal neovascularization in a patient with Crohn's disease.

Case reports in ophthalmology

Giuseppe Casalino, Giuseppe Querques, Federico Corvi, Enrico Borrelli, Giacinto Triolo, Giuseppe Alvise Ramirez, Francesco Bandello

Affiliations

  1. Department of Ophthalmology, San Raffaele Scientific Institute, Vita-Salute University, Milan, Italy.
  2. Department of Immunology, San Raffaele Scientific Institute, Vita-Salute University, Milan, Italy.

PMID: 25232338 PMCID: PMC4163694 DOI: 10.1159/000365881

Abstract

PURPOSE: To report a case of subfoveal choroidal neovascularization (CNV) in a patient with Crohn's disease (CD) and to discuss a possible association between these two conditions.

METHODS: This is an observational case report.

RESULTS: A 69-year-old male affected by CD was referred to our department because of sudden visual acuity drop in the left eye. A subfoveal CNV was diagnosed based on slit-lamp fundus biomicroscopy and fluorescein angiography. Color fundus photography, infrared autofluorescence and spectral-domain optical coherence tomography imaging of both eyes were also performed. Following six intravitreal ranibizumab injections, visual improvement was obtained with no related adverse events.

CONCLUSION: We report a case of CNV as a possible rare extraintestinal manifestation of CD. The use of ranibizumab successfully impacted on CNV, while not affecting CD, which remained quiescent.

Keywords: Anti-VEGF; Choroidal neovascularization; Crohn's disease; Fluorescein angiography; Intravitreal ranibizumab; Optical coherence tomography

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