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Holt PG, Sedgwick JD. Suppression of IgE responses following inhalation of antigen A natural homeostatic mechanism which limits sensitization to aeroallergens. Immunol Today. 1987;8(1):14-5doi: 10.1016/0167-5699(87)90825-5.
Holt, P. G., & Sedgwick, J. D. (1987). Suppression of IgE responses following inhalation of antigen A natural homeostatic mechanism which limits sensitization to aeroallergens. Immunology today, 8(1), 14-5. https://doi.org/10.1016/0167-5699(87)90825-5
Holt, P G, and Sedgwick, J D. "Suppression of IgE responses following inhalation of antigen A natural homeostatic mechanism which limits sensitization to aeroallergens." Immunology today vol. 8,1 (1987): 14-5. doi: https://doi.org/10.1016/0167-5699(87)90825-5
Holt PG, Sedgwick JD. Suppression of IgE responses following inhalation of antigen A natural homeostatic mechanism which limits sensitization to aeroallergens. Immunol Today. 1987;8(1):14-5. doi: 10.1016/0167-5699(87)90825-5. PMID: 25291491.
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Immunol Today. 1987;8(1):14-5. doi: 10.1016/0167-5699(87)90825-5.

Suppression of IgE responses following inhalation of antigen A natural homeostatic mechanism which limits sensitization to aeroallergens.

Immunology today

P G Holt, J D Sedgwick

Affiliations

  1. Clinical Immunology Research Unit, Princess Margaret Hospital, Subiaco 6008, Western Australia.
  2. MRC Cellular Immunology Unit, Sir William Dunn School of Pathology, Oxford OX1 3RE, UK.

PMID: 25291491 DOI: 10.1016/0167-5699(87)90825-5

Abstract

Contract between immune cells and airborne antigens is limited in the upper respiratory tract (URT) by physical barriers such as mucous. But some antigen does penetrate the URT epithelium. In this article, Patrick Holt and Jon Sedgwick postulate the existence of back-up immune mechanisms which prevent sensitization to antigens which cross epithelial barriers.

Copyright © 1987. Published by Elsevier B.V.

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