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Cerny J, Kelsoe G. Priority of the anti-idiotypic response after antigen administration: artefact or intriguing network mechanism?. Immunol Today. 1984;5(3):61-3doi: 10.1016/0167-5699(84)90165-8.
Cerny, J., & Kelsoe, G. (1984). Priority of the anti-idiotypic response after antigen administration: artefact or intriguing network mechanism?. Immunology today, 5(3), 61-3. https://doi.org/10.1016/0167-5699(84)90165-8
Cerny, J, and Kelsoe, G. "Priority of the anti-idiotypic response after antigen administration: artefact or intriguing network mechanism?." Immunology today vol. 5,3 (1984): 61-3. doi: https://doi.org/10.1016/0167-5699(84)90165-8
Cerny J, Kelsoe G. Priority of the anti-idiotypic response after antigen administration: artefact or intriguing network mechanism?. Immunol Today. 1984 Mar;5(3):61-3. doi: 10.1016/0167-5699(84)90165-8. PMID: 25291513.
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Immunol Today. 1984 Mar;5(3):61-3. doi: 10.1016/0167-5699(84)90165-8.

Priority of the anti-idiotypic response after antigen administration: artefact or intriguing network mechanism?.

Immunology today

J Cerny, G Kelsoe

Affiliations

  1. Department of Microbiology, University of Texas Medical Branch, Galveston, TX 77550, USA.

PMID: 25291513 DOI: 10.1016/0167-5699(84)90165-8

Abstract

Immunization triggers at least two speck responses measurable at cellular and humoral levels: the antigen-driven proliferation of idiotype-bearing (idt+) cells; and an autochthonous anti-idt response'. As the expansion of the idt* clone(s) is presumed to provide the activating stimulus for the complementary response, one expects the proliferation of anti-idt clones to follow the idt response at an interval equivalent to the time required for ~pmphocyte activation. However, there have been several reports of an autochthonous anti-idt response preceding the expansion of antigen-driven idt' clone(s). In this brief commentary, we examine these reports and offer some suggestions that may resolve this apparent paradox.

Copyright © 1984. Published by Elsevier B.V.

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