Display options
Cite
Wang YX, Griffith JF, Leung JC, et al. Age related reduction of T1rho and T2 magnetic resonance relaxation times of lumbar intervertebral disc. Quant Imaging Med Surg. 2014;4(4):259-64doi: 10.3978/j.issn.2223-4292.2014.07.14.
Wang, Y. X., Griffith, J. F., Leung, J. C., & Yuan, J. (2014). Age related reduction of T1rho and T2 magnetic resonance relaxation times of lumbar intervertebral disc. Quantitative imaging in medicine and surgery, 4(4), 259-64. https://doi.org/10.3978/j.issn.2223-4292.2014.07.14
Wang, Yi-Xiang J, et al. "Age related reduction of T1rho and T2 magnetic resonance relaxation times of lumbar intervertebral disc." Quantitative imaging in medicine and surgery vol. 4,4 (2014): 259-64. doi: https://doi.org/10.3978/j.issn.2223-4292.2014.07.14
Wang YX, Griffith JF, Leung JC, Yuan J. Age related reduction of T1rho and T2 magnetic resonance relaxation times of lumbar intervertebral disc. Quant Imaging Med Surg. 2014 Aug;4(4):259-64. doi: 10.3978/j.issn.2223-4292.2014.07.14. PMID: 25202661; PMCID: PMC4137186.
Copy Download .nbib Format: NLM
Share it on

Quant Imaging Med Surg. 2014 Aug;4(4):259-64. doi: 10.3978/j.issn.2223-4292.2014.07.14.

Age related reduction of T1rho and T2 magnetic resonance relaxation times of lumbar intervertebral disc.

Quantitative imaging in medicine and surgery

Yi-Xiang J Wang, James F Griffith, Jason C S Leung, Jing Yuan

Affiliations

  1. 1 Department of Imaging and Interventional Radiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China ; 2 School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.

PMID: 25202661 PMCID: PMC4137186 DOI: 10.3978/j.issn.2223-4292.2014.07.14

Abstract

This report aims to study the age related T1rho and T2 relaxation time changes in lumbar intervertebral disc. Lumbar sagittal magnetic resonance imaging (MRI) was performed with a 3 Tesla scanner in 52 subjects. With a spin-lock frequency of 500 Hz, T1rho was measured using a rotary echo spin-lock pulse embedded in a 3D balanced fast field echo sequence. A multi-echo turbo spin echo sequence was used for T2 mapping. Regions-of-interest were drawn over the T1rho and T2 maps, including nucleus pulposus and annulus fibrosus. For L1/2-L4/5 discs, results showed the age associated reduction of T1rho of nucleus pulposus had a of slope of -1.06, the reduction of T2 of nucleus pulposus had a slope of -1.47, the reduction of T1rho of annulus fibrosus had a slope of -0.25, and the reduction of T2 of annulus fibrosus had a slope of -0.18, with all the slopes significantly non-zero. In nucleus pulposus the slope of T2 was slightly steeper than that of T1rho (P=0.085), while in annulus fibrosus the slope of T1rho was slightly steeper than that of T2 (P=0.31). We conclude that significant age related reduction of T1rho and T2 magnetic resonance relaxation times of lumbar intervertebral disc was observed, however, the relative performances of T1rho vs. T2 were broadly similar.

Keywords: Magnetic resonance imaging (MRI); T1rho; T2; annulus fibrosus; degeneration; disc; nucleus pulposus; relaxation time

References

  1. Spine (Phila Pa 1976). 2010 Mar 1;35(5):531-6 - PubMed
  2. Radiology. 2014 May;271(2):408-15 - PubMed
  3. J Bone Joint Surg Am. 2001 Sep;83(9):1306-11 - PubMed
  4. Spine (Phila Pa 1976). 2006 May 15;31(11):1253-7 - PubMed
  5. Radiology. 2007 Oct;245(1):43-61 - PubMed
  6. Radiology. 2010 Nov;257(2):318-20 - PubMed
  7. J Clin Invest. 1996 Aug 15;98(4):996-1003 - PubMed
  8. Eur Radiol. 2012 Aug;22(8):1709-16 - PubMed
  9. Spine (Phila Pa 1976). 2009 Mar 1;34(5):520-4 - PubMed
  10. Spine (Phila Pa 1976). 2000 Jan 15;25(2):218-23 - PubMed
  11. Quant Imaging Med Surg. 2013 Feb;3(1):54-8 - PubMed
  12. Acta Radiol. 2001 Nov;42(6):585-91 - PubMed
  13. Skeletal Radiol. 2012 Feb;41(2):163-7 - PubMed
  14. Radiology. 2011 Jun;259(3):712-9 - PubMed
  15. Magn Reson Med. 2001 Sep;46(3):419-23 - PubMed
  16. Quant Imaging Med Surg. 2014 Jun;4(3):152-5 - PubMed
  17. Spine (Phila Pa 1976). 2006 Aug 15;31(18):2151-61 - PubMed
  18. Magn Reson Imaging. 2006 Oct;24(8):1001-7 - PubMed
  19. Acta Orthop Scand Suppl. 1998 Jun;281:28-31 - PubMed
  20. J Magn Reson. 2003 May;162(1):113-21 - PubMed
  21. Spine J. 2001 May-Jun;1(3):205-14 - PubMed
  22. Arthritis Rheum. 2013 Apr;65(4):1004-10 - PubMed
  23. PLoS One. 2013 Jul 26;8(7):e69052 - PubMed
  24. Spine (Phila Pa 1976). 2001 Oct 1;26(19):E437-44 - PubMed
  25. Eur Radiol. 2013 Jan;23(1):228-34 - PubMed
  26. Eur J Radiol. 2014 Jun;83(6):900-904 - PubMed
  27. AJNR Am J Neuroradiol. 2011 Oct;32(9):1617-23 - PubMed
  28. Eur Spine J. 2006 Aug;15 Suppl 3:S338-44 - PubMed
  29. J Orthop Res. 1992 Jul;10(4):552-61 - PubMed

Publication Types