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Gloria-Bottini F, Pietropolli A, Neri A, et al. A study of adenylate kinase locus 1 (ak 1 ) genetic polymorphism in diabetic pregnancy. J Reprod Infertil. 2014;15(3):161-4
Gloria-Bottini, F., Pietropolli, A., Neri, A., Coppeta, L., Magrini, A., & Bottini, E. (2014). A study of adenylate kinase locus 1 (ak 1 ) genetic polymorphism in diabetic pregnancy. Journal of reproduction & infertility, 15(3), 161-4.
Gloria-Bottini, Fulvia, et al. "A study of adenylate kinase locus 1 (ak 1 ) genetic polymorphism in diabetic pregnancy." Journal of reproduction & infertility vol. 15,3 (2014): 161-4.
Gloria-Bottini F, Pietropolli A, Neri A, Coppeta L, Magrini A, Bottini E. A study of adenylate kinase locus 1 (ak 1 ) genetic polymorphism in diabetic pregnancy. J Reprod Infertil. 2014 Jul;15(3):161-4. PMID: 25202675; PMCID: PMC4138424.
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J Reprod Infertil. 2014 Jul;15(3):161-4.

A study of adenylate kinase locus 1 (ak 1 ) genetic polymorphism in diabetic pregnancy.

Journal of reproduction & infertility

Fulvia Gloria-Bottini, Adalgisa Pietropolli, Anna Neri, Luca Coppeta, Andrea Magrini, Egidio Bottini

Affiliations

  1. Department of Biomedicine and Prevention, School of Medicine, University of Rome Tor Vergata, Rome, Italy.

PMID: 25202675 PMCID: PMC4138424

Abstract

BACKGROUND: Previous studies suggest that adenylate kinase locus 1 (Ak 1 ) has an important role in the control of blood glucose level and in the glycation of structural and functional proteins in type 2 diabetes and in the balanced development of feto-placental unit in healthy puerperae (HP). In this study, an attempt was made to investigate the relationship of Ak 1 with maternal and neonatal parameters in puerperae with gestational diabetes (GDP) and with preexisting type 1 diabetes (T1DP).

METHODS: This study was carried on 402 HP, 347 consecutive healthy newborns, 102 GDP and 111 T1DP with their newborn infants. Ak 1 phenotype was determined by starch gel electrophoresis. Chi-square test of independence was carried out by SPSS program. The analysis of three way contingency table was carried out by a loglinear model. Significant level was 0.05.

RESULTS: In T1DP, the frequency of Ak 1 *2 allele was higher than in GDP and in HP. Serum glucose level was higher in T1DP than in GDP with higher values in carriers of Ak 1 *2 allele. Neonatal hypoglycemia was more frequent in T1DP than in GDP with a positive association with Ak 1 *2 allele. The correlation between birth weight (BW) and placental weight (PW) was lower in infants from T1DP than HP. In healthy puerperae the correlation is higher in Ak 1 2-1 than in Ak 1 1 phenotype while in diabetic puerperae the pattern is reversed with lower values in Ak 1 2-1 than in Ak 1 1 phenotype. The lowest value of correlation is observed in infants from T1D mothers carrying the Ak 1 *2 allele.

CONCLUSION: The data confirmed the involvement of Ak 1 in glucose metabolism and showed a disturbance of the balance between placental and fetal growth which was more marked in T1DP.

Keywords: Adenylate kinase; BW-PW correlation; Gestational diabetes; Neonatal hypoglycemia; Preexisting T1D

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