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Kim BD. Foldback intercoil DNA and the mechanism of DNA transposition. Genomics Inform. 2014;12(3):80-6doi: 10.5808/GI.2014.12.3.80.
Kim, B. D. (2014). Foldback intercoil DNA and the mechanism of DNA transposition. Genomics & informatics, 12(3), 80-6. https://doi.org/10.5808/GI.2014.12.3.80
Kim, Byung-Dong. "Foldback intercoil DNA and the mechanism of DNA transposition." Genomics & informatics vol. 12,3 (2014): 80-6. doi: https://doi.org/10.5808/GI.2014.12.3.80
Kim BD. Foldback intercoil DNA and the mechanism of DNA transposition. Genomics Inform. 2014 Sep;12(3):80-6. doi: 10.5808/GI.2014.12.3.80. Epub 2014 Sep 30. PMID: 25317106; PMCID: PMC4196379.
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Genomics Inform. 2014 Sep;12(3):80-6. doi: 10.5808/GI.2014.12.3.80. Epub 2014 Sep 30.

Foldback intercoil DNA and the mechanism of DNA transposition.

Genomics & informatics

Byung-Dong Kim

Affiliations

  1. Department of Plant Science, Seoul National University, Seoul 151-921, Korea. ; The Korean Academy of Science and Technology, Seongnam 463-808, Korea.

PMID: 25317106 PMCID: PMC4196379 DOI: 10.5808/GI.2014.12.3.80

Abstract

Foldback intercoil (FBI) DNA is formed by the folding back at one point of a non-helical parallel track of double-stranded DNA at as sharp as 180° and the intertwining of two double helixes within each other's major groove to form an intercoil with a diameter of 2.2 nm. FBI DNA has been suggested to mediate intra-molecular homologous recombination of a deletion and inversion. Inter-molecular homologous recombination, known as site-specific insertion, on the other hand, is mediated by the direct perpendicular approach of the FBI DNA tip, as the attP site, onto the target DNA, as the attB site. Transposition of DNA transposons involves the pairing of terminal inverted repeats and 5-7-bp tandem target duplication. FBI DNA configuration effectively explains simple as well as replicative transposition, along with the involvement of an enhancer element. The majority of diverse retrotransposable elements that employ a target site duplication mechanism is also suggested to follow the FBI DNA-mediated perpendicular insertion of the paired intercoil ends by non-homologous end-joining, together with gap filling. A genome-wide perspective of transposable elements in light of FBI DNA is discussed.

Keywords: DNA end-joining repair; DNA transposable elements; foldback intercoil DNA; homologous recombination; retroelements; target site duplication

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