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Onaolapo OJ, Onaolapo AY, Abiola AA, et al. Central depressant and nootropic effects of daytime melatonin in mice. Ann Neurosci. 2014;21(3):90-6doi: 10.5214/ans.0972.7531.210304.
Onaolapo, O. J., Onaolapo, A. Y., Abiola, A. A., & Lillian, E. A. (2014). Central depressant and nootropic effects of daytime melatonin in mice. Annals of neurosciences, 21(3), 90-6. https://doi.org/10.5214/ans.0972.7531.210304
Onaolapo, Olakunle J, et al. "Central depressant and nootropic effects of daytime melatonin in mice." Annals of neurosciences vol. 21,3 (2014): 90-6. doi: https://doi.org/10.5214/ans.0972.7531.210304
Onaolapo OJ, Onaolapo AY, Abiola AA, Lillian EA. Central depressant and nootropic effects of daytime melatonin in mice. Ann Neurosci. 2014 Jul;21(3):90-6. doi: 10.5214/ans.0972.7531.210304. PMID: 25206072; PMCID: PMC4158777.
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Ann Neurosci. 2014 Jul;21(3):90-6. doi: 10.5214/ans.0972.7531.210304.

Central depressant and nootropic effects of daytime melatonin in mice.

Annals of neurosciences

Olakunle J Onaolapo, Adejoke Y Onaolapo, Akanni A Abiola, Eniafe A Lillian

Affiliations

  1. Department of Pharmacology, Faculty of Basic Medical Sciences, College of Health Sciences, Ladoke Akintola University of Technology, Oshogbo, Nigeria;
  2. Department of Human Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomosho, Oyo State, Nigeria.

PMID: 25206072 PMCID: PMC4158777 DOI: 10.5214/ans.0972.7531.210304

Abstract

BACKGROUND: Effects of orally administered daytime melatonin on novelty induced behaviors and spatial working memory in mice were evaluated using the open field, the Y maze and the radial arm maze.

PURPOSE: To ascertain the possible nootropic and/or central excitatory or inhibitory effects of daytime oral melatonin in mice.

METHODS: Adult male mice from our colony, assigned to three and four groups for open field tests and memory tests respectively were given vehicle (normal saline), a standard drug Scopolamine at 0.5 mg/kg i.p, single dose, 30 minutes before behavioral study) or one of two doses of melatonin (5 and 10 mg/kg daily for a period of 30 days). All administrations were done between 8.00 a.m. and 9.00 a.m. daily. Behavioral tests were carried out on day 30 after administration. Results were analysed using a one-way ANOVA followed by a posthoc test (Student-Newman-Keul's) and expressed as mean ± S.E.M.

RESULTS: Open field tests revealed a significant reduction in rearing and grooming behaviors at both doses tested while no significant changes in horizontal locomotion were seen. Y maze studies showed an improvement in spatial memory in mice that received 5 mg/kg of melatonin when compared to scopolamine control. At 10 mg/kg, no significant improvement was seen. A significant increase in the radial arm maze spatial working memory following melatonin administration was seen at 5 mg/kg and 10 mg/kg compared to scopolamine control. Radial arm maze exploration was also significantly reduced.

CONCLUSION: The study demonstrates the ability of exogenously administered melatonin, to affect both central excitation and spatial working memory in mice even when given orally.

Keywords: Animal models; Memory; Neurobehavior; Novelty induced behaviors

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