Display options
Cite
Hemmati AA, Mojiri Forushani H, Mohammad Asgari H. Wound healing potential of topical amlodipine in full thickness wound of rabbit. Jundishapur J Nat Pharm Prod. 2014;9(3):e15638doi: 10.17795/jjnpp-15638.
Hemmati, A. A., Mojiri Forushani, H., & Mohammad Asgari, H. (2014). Wound healing potential of topical amlodipine in full thickness wound of rabbit. Jundishapur journal of natural pharmaceutical products, 9(3), e15638. https://doi.org/10.17795/jjnpp-15638
Hemmati, Ali Asghar, et al. "Wound healing potential of topical amlodipine in full thickness wound of rabbit." Jundishapur journal of natural pharmaceutical products vol. 9,3 (2014): e15638. doi: https://doi.org/10.17795/jjnpp-15638
Hemmati AA, Mojiri Forushani H, Mohammad Asgari H. Wound healing potential of topical amlodipine in full thickness wound of rabbit. Jundishapur J Nat Pharm Prod. 2014 Jun 16;9(3):e15638. doi: 10.17795/jjnpp-15638. eCollection 2014 Aug. PMID: 25237643; PMCID: PMC4165190.
Copy Download .nbib Format: NLM
Share it on

Jundishapur J Nat Pharm Prod. 2014 Jun 16;9(3):e15638. doi: 10.17795/jjnpp-15638. eCollection 2014 Aug.

Wound healing potential of topical amlodipine in full thickness wound of rabbit.

Jundishapur journal of natural pharmaceutical products

Ali Asghar Hemmati, Hoda Mojiri Forushani, Hossein Mohammad Asgari

Affiliations

  1. School of Pharmacy, The Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran.
  2. School of Natural Resources, Khoramshahr University of Marine Science and Technology, Khoramshahr, IR Iran.

PMID: 25237643 PMCID: PMC4165190 DOI: 10.17795/jjnpp-15638

Abstract

BACKGROUND: Wound healing is a complicated and integrated process. Researches have indicated the wound healing effects of calcium channel blockers in animal models in recent years.

OBJECTIVES: The aim of this study was to evaluate the wound-healing activity of amlodipine as a calcium channel blocker and combination of amlodipine with phenytoin on excisional cutaneous wound models in rabbit.

MATERIALS AND METHODS: Animals were divided into 5 groups (n = 5). The control group was treated topically with eucerin. The untreated control group received no healing agent. The reference standard group was treated with phenytoin1%. A treatment group was treated with amlodipine 1%. The last group was treated with combination of amlodipine1% and phenytoin 1%.

RESULTS: Results indicated significant difference between days needed for complete healing in both of the treatment groups. Wound closure was completed on 13th day and 9th day in amlodipine and combination groups respectively.

CONCLUSIONS: In conclusion, calcium channel blockers can be used to enhance wound healing, especially if this treatment becomes with phenytoin. Further studies are needed to find out the mechanism of this healing effect.

Keywords: Amlodipine; Calcium Channel Blocker; Phenytoin; Rabbits; Wound Healing

References

  1. Phytochemistry. 2001 Feb;56(3):237-43 - PubMed
  2. N Engl J Med. 1999 Sep 2;341(10):738-46 - PubMed
  3. J Evid Based Dent Pract. 2012 Sep;12(3 Suppl):147-8 - PubMed
  4. Lancet. 1993 Apr 24;341(8852):1102-3 - PubMed
  5. J Periodontol. 2008 Jan;79(1):114-22 - PubMed
  6. Surg Gynecol Obstet. 1982 Mar;154(3):421-9 - PubMed
  7. J Surg Res. 2011 Jul;169(1):e101-7 - PubMed
  8. J Periodontol. 1997 Jul;68(7):676-8 - PubMed
  9. Am Heart J. 1989 Nov;118(5 Pt 2):1100-3 - PubMed
  10. Adverse Drug React Toxicol Rev. 2001 Jun;20(2):89-103 - PubMed
  11. J Periodontol. 1999 Jan;70(1):63-7 - PubMed
  12. J Invest Surg. 1991;4(3):313-22 - PubMed
  13. Dermatol Online J. 2004 Jul 15;10(1):5 - PubMed
  14. Biochem Biophys Res Commun. 1994 Sep 30;203(3):1803-8 - PubMed
  15. Ann Pharmacother. 1996 Jul-Aug;30(7-8):768-75 - PubMed
  16. J Young Pharm. 2010 Jan;2(1):59-62 - PubMed
  17. Med Oral Patol Oral Cir Bucal. 2006 Nov 01;11(6):E480-2 - PubMed
  18. J Ethnopharmacol. 2007 Nov 1;114(2):103-13 - PubMed
  19. Indian J Physiol Pharmacol. 1991 Oct;35(4):217-31 - PubMed
  20. J Periodontol. 2006 Dec;77(12):2005-10 - PubMed
  21. J Surg Res. 1990 Nov;49(5):463-6 - PubMed
  22. J Clin Periodontol. 2010 Jul;37(7):625-30 - PubMed
  23. J Ethnopharmacol. 2012 Aug 1;142(3):714-22 - PubMed
  24. J Oral Pathol Med. 2000 Nov;29(10):491-9 - PubMed
  25. Br J Plast Surg. 1995 Jun;48(4):189-97 - PubMed
  26. Circulation. 2004 Oct 19;110(16):2484-93 - PubMed

Publication Types