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Rajoriya N, Fergusson JR, Leithead JA, et al. Gamma Delta T-lymphocytes in Hepatitis C and Chronic Liver Disease. Front Immunol. 2014;5:400doi: 10.3389/fimmu.2014.00400.
Rajoriya, N., Fergusson, J. R., Leithead, J. A., & Klenerman, P. (2014). Gamma Delta T-lymphocytes in Hepatitis C and Chronic Liver Disease. Frontiers in immunology, 5400. https://doi.org/10.3389/fimmu.2014.00400
Rajoriya, Neil, et al. "Gamma Delta T-lymphocytes in Hepatitis C and Chronic Liver Disease." Frontiers in immunology vol. 5 (2014): 400. doi: https://doi.org/10.3389/fimmu.2014.00400
Rajoriya N, Fergusson JR, Leithead JA, Klenerman P. Gamma Delta T-lymphocytes in Hepatitis C and Chronic Liver Disease. Front Immunol. 2014 Aug 26;5:400. doi: 10.3389/fimmu.2014.00400. eCollection 2014. PMID: 25206355; PMCID: PMC4143964.
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Front Immunol. 2014 Aug 26;5:400. doi: 10.3389/fimmu.2014.00400. eCollection 2014.

Gamma Delta T-lymphocytes in Hepatitis C and Chronic Liver Disease.

Frontiers in immunology

Neil Rajoriya, Joannah Ruth Fergusson, Joanna A Leithead, Paul Klenerman

Affiliations

  1. Peter Medawar Building for Pathogen Research , Oxford , UK.
  2. Liver Unit, Queen Elizabeth Hospital , Birmingham , UK ; NIHR Biomedical Research Unit and Centre for Liver Research, University of Birmingham , Birmingham , UK.
  3. Peter Medawar Building for Pathogen Research , Oxford , UK ; NIHR Biomedical Research Centre, Oxford Radcliffe Hospital , Oxford , UK.

PMID: 25206355 PMCID: PMC4143964 DOI: 10.3389/fimmu.2014.00400

Abstract

Discovered 30 years ago, gamma delta (γδ) T-lymphocytes remain an intriguing and enigmatic T-cell subset. Although in humans they comprise a small fraction of the total circulating T-lymphocyte pool, they represent an important T-cell subset in tissues such as the liver, with roles bridging the innate and adaptive immune systems. The associations of γδ T-lymphocytes with chronic liver disease have been explored - however, there remain conflicting data as to whether these T-cells are pathogenic or protective. In patients with some forms of liver disease, their expansion in the periphery and especially in the liver may indeed help pathogen clearance, while in other conditions their presence may, in contrast, contribute to disease progression. γδ T-cells can also express CD161, a C-type lectin, and such cells have been found to be involved in the pathogenesis of inflammatory disease. CD161+ T-cells of diverse subsets are known to be enriched in the livers of patients with chronic hepatitis C. This article serves to provide a review of the γδ T-cell population and its role in hepatitis C and other chronic liver diseases, and also explores a potential role of the CD161+ γδ T-cells in liver diseases.

Keywords: CD161; gamma delta T-lymphocytes; γδ T-cells

References

  1. Mol Med. 2001 Jan;7(1):11-9 - PubMed
  2. Science. 1998 Mar 13;279(5357):1737-40 - PubMed
  3. J Immunol. 2004 Jun 1;172(11):6578-86 - PubMed
  4. Immunity. 2009 Aug 21;31(2):184-96 - PubMed
  5. AIDS Res Hum Retroviruses. 2001 Sep 20;17(14):1357-63 - PubMed
  6. Cell Immunol. 2001 Sep 15;212(2):110-7 - PubMed
  7. J Exp Med. 2009 Mar 16;206(3):525-34 - PubMed
  8. Gastroenterology. 2001 Jan;120(1):250-60 - PubMed
  9. Clin Immunol. 2004 Oct;113(1):56-63 - PubMed
  10. Blood. 2010 Sep 23;116(12):2164-72 - PubMed
  11. J Immunol. 1995 Jun 1;154(11):5832-41 - PubMed
  12. Cancer Immunol Immunother. 2008 Apr;57(4):531-9 - PubMed
  13. N Engl J Med. 2001 Jul 5;345(1):41-52 - PubMed
  14. Front Immunol. 2012 Nov 20;3:346 - PubMed
  15. J Infect Dis. 2008 Dec 1;198(11):1643-50 - PubMed
  16. J Immunol. 2007 Apr 1;178(7):4304-14 - PubMed
  17. Cell Mol Immunol. 2008 Jun;5(3):203-8 - PubMed
  18. Eur J Immunol. 2010 Aug;40(8):2174-81 - PubMed
  19. J Exp Med. 2011 Mar 14;208(3):491-503 - PubMed
  20. Immunol Today. 1989 Jun;10(6):186-8 - PubMed
  21. Nature. 1986 Jul 10-16;322(6075):145-9 - PubMed
  22. Gut. 2007 Dec;56(12):1743-6 - PubMed
  23. J Clin Invest. 1999 May 15;103(10):1437-49 - PubMed
  24. Nat Immunol. 2014 Jan;15(1):80-7 - PubMed
  25. J Immunol. 1990 Nov 1;145(9):2827-32 - PubMed
  26. Transpl Int. 2010 Oct;23(10):1045-55 - PubMed
  27. Nat Immunol. 2013 Nov;14(11):1137-45 - PubMed
  28. Blood. 2011 Jul 7;118(1):129-38 - PubMed
  29. Cell Mol Life Sci. 2006 Sep;63(18):2089-94 - PubMed
  30. Hepatology. 2008 Feb;47(2):396-406 - PubMed
  31. J Immunol. 2011 Sep 1;187(5):2783-93 - PubMed
  32. Gut. 2011 Jun;60(6):837-45 - PubMed
  33. Am J Gastroenterol. 1992 Aug;87(8):1018-22 - PubMed
  34. Int Immunol. 2006 Jan;18(1):11-8 - PubMed
  35. J Immunol. 1997 Aug 1;159(3):1328-35 - PubMed
  36. J Exp Med. 2007 Aug 6;204(8):1849-61 - PubMed
  37. J Immunol. 2001 Dec 1;167(11):6195-201 - PubMed
  38. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3006-11 - PubMed
  39. J Immunol. 1997 Oct 15;159(8):3723-30 - PubMed
  40. Hum Immunol. 1999 Jan;60(1):20-31 - PubMed
  41. PLoS Biol. 2009 Mar 10;7(3):e54 - PubMed
  42. Nature. 1984 Jun 28-Jul 4;309(5971):757-62 - PubMed
  43. J Immunol. 2002 Jun 15;168(12):6071-7 - PubMed
  44. Neuro Oncol. 2009 Aug;11(4):357-67 - PubMed
  45. Liver Int. 2013 Jan;33(1):127-36 - PubMed
  46. Eur J Cardiothorac Surg. 2010 May;37(5):1191-7 - PubMed
  47. Eur J Immunol. 2014 Jan;44(1):195-203 - PubMed
  48. Eur J Immunol. 1997 Sep;27(9):2345-50 - PubMed
  49. Hepatology. 1996 May;23(5):988-93 - PubMed
  50. J Immunol. 2006 Jan 1;176(1):211-6 - PubMed
  51. J Immunol. 1995 May 1;154(9):4883-94 - PubMed
  52. Cell Mol Life Sci. 2011 Jul;68(14):2357-70 - PubMed
  53. Scand J Immunol. 2003 Jul;58(1):99-105 - PubMed
  54. APMIS. 2009 Nov;117(11):779-85 - PubMed
  55. Transpl Immunol. 2007 Feb;17(2):94-7 - PubMed
  56. Hepatology. 2010 Sep;52(3):999-1007 - PubMed
  57. Cancer Immunol Immunother. 2009 Apr;58(4):493-502 - PubMed
  58. Blood. 2012 Jan 12;119(2):422-33 - PubMed
  59. J Immunol. 1997 Oct 1;159(7):3629-37 - PubMed
  60. Clin Exp Immunol. 2002 Jul;129(1):92-8 - PubMed
  61. Clin Dev Immunol. 2011;2011:587315 - PubMed
  62. Int Arch Allergy Immunol. 2000 May;122(1):1-7 - PubMed
  63. J Clin Microbiol. 1992 Mar;30(3):729-31 - PubMed
  64. Gut. 2012 Aug;61(8):1226-34 - PubMed
  65. Nat Immunol. 2013 Sep;14(9):908-16 - PubMed
  66. Scand J Immunol. 1989 Dec;30(6):665-72 - PubMed
  67. J Immunol. 1999 Apr 1;162(7):4349-54 - PubMed
  68. Nat Rev Immunol. 2010 Jul;10(7):467-78 - PubMed
  69. Int Immunol. 2005 Nov;17(11):1419-28 - PubMed
  70. J Exp Med. 2008 Aug 4;205(8):1903-16 - PubMed
  71. J Hepatol. 2002 Oct;37(4):514-22 - PubMed
  72. Gut. 1990 Aug;31(8):841-4 - PubMed
  73. Hepatology. 2001 May;33(5):1312-20 - PubMed
  74. J Immunol. 1994 Sep 15;153(6):2417-28 - PubMed
  75. J Immunol. 2010 Jun 15;184(12):7268-80 - PubMed
  76. J Immunol. 1992 Mar 15;148(6):1871-8 - PubMed
  77. Eur J Immunol. 1998 May;28(5):1611-6 - PubMed
  78. Blood. 2011 Jan 27;117(4):1250-9 - PubMed
  79. J Exp Med. 2000 Mar 20;191(6):937-48 - PubMed
  80. Am J Transplant. 2007 Feb;7(2):309-19 - PubMed

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