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De Marco RJ, Groneberg AH, Yeh CM, et al. The behavior of larval zebrafish reveals stressor-mediated anorexia during early vertebrate development. Front Behav Neurosci. 2014;8:367doi: 10.3389/fnbeh.2014.00367.
De Marco, R. J., Groneberg, A. H., Yeh, C. M., Treviño, M., & Ryu, S. (2014). The behavior of larval zebrafish reveals stressor-mediated anorexia during early vertebrate development. Frontiers in behavioral neuroscience, 8367. https://doi.org/10.3389/fnbeh.2014.00367
De Marco, Rodrigo J, et al. "The behavior of larval zebrafish reveals stressor-mediated anorexia during early vertebrate development." Frontiers in behavioral neuroscience vol. 8 (2014): 367. doi: https://doi.org/10.3389/fnbeh.2014.00367
De Marco RJ, Groneberg AH, Yeh CM, Treviño M, Ryu S. The behavior of larval zebrafish reveals stressor-mediated anorexia during early vertebrate development. Front Behav Neurosci. 2014 Oct 20;8:367. doi: 10.3389/fnbeh.2014.00367. eCollection 2014. PMID: 25368561; PMCID: PMC4202704.
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Front Behav Neurosci. 2014 Oct 20;8:367. doi: 10.3389/fnbeh.2014.00367. eCollection 2014.

The behavior of larval zebrafish reveals stressor-mediated anorexia during early vertebrate development.

Frontiers in behavioral neuroscience

Rodrigo J De Marco, Antonia H Groneberg, Chen-Min Yeh, Mario Treviño, Soojin Ryu

Affiliations

  1. Developmental Genetics of the Nervous System, Max Planck Institute for Medical Research Heidelberg, Germany.
  2. Laboratorio de Plasticidad Cortical y Aprendizaje Perceptual, Instituto de Neurociencias, Universidad de Guadalajara Guadalajara, México.

PMID: 25368561 PMCID: PMC4202704 DOI: 10.3389/fnbeh.2014.00367

Abstract

The relationship between stress and food consumption has been well documented in adults but less so in developing vertebrates. Here we demonstrate that an encounter with a stressor can suppress food consumption in larval zebrafish. Furthermore, we provide indication that food intake suppression cannot be accounted for by changes in locomotion, oxygen consumption and visual responses, as they remain unaffected after exposure to a potent stressor. We also show that feeding reoccurs when basal levels of cortisol (stress hormone in humans and teleosts) are re-established. The results present evidence that the onset of stress can switch off the drive for feeding very early in vertebrate development, and add a novel endpoint for analyses of metabolic and behavioral disorders in an organism suitable for high-throughput genetics and non-invasive brain imaging.

Keywords: HPA-axis; behavior; feeding; larval zebrafish; stress response

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