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Hussaarts L, Yazdanbakhsh M, Guigas B. Priming dendritic cells for th2 polarization: lessons learned from helminths and implications for metabolic disorders. Front Immunol. 2014;5:499doi: 10.3389/fimmu.2014.00499.
Hussaarts, L., Yazdanbakhsh, M., & Guigas, B. (2014). Priming dendritic cells for th2 polarization: lessons learned from helminths and implications for metabolic disorders. Frontiers in immunology, 5499. https://doi.org/10.3389/fimmu.2014.00499
Hussaarts, Leonie, et al. "Priming dendritic cells for th2 polarization: lessons learned from helminths and implications for metabolic disorders." Frontiers in immunology vol. 5 (2014): 499. doi: https://doi.org/10.3389/fimmu.2014.00499
Hussaarts L, Yazdanbakhsh M, Guigas B. Priming dendritic cells for th2 polarization: lessons learned from helminths and implications for metabolic disorders. Front Immunol. 2014 Oct 20;5:499. doi: 10.3389/fimmu.2014.00499. eCollection 2014. PMID: 25368615; PMCID: PMC4202775.
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Front Immunol. 2014 Oct 20;5:499. doi: 10.3389/fimmu.2014.00499. eCollection 2014.

Priming dendritic cells for th2 polarization: lessons learned from helminths and implications for metabolic disorders.

Frontiers in immunology

Leonie Hussaarts, Maria Yazdanbakhsh, Bruno Guigas

Affiliations

  1. Department of Parasitology, Leiden University Medical Center , Leiden , Netherlands.
  2. Department of Parasitology, Leiden University Medical Center , Leiden , Netherlands ; Department of Molecular Cell Biology, Leiden University Medical Center , Leiden , Netherlands.

PMID: 25368615 PMCID: PMC4202775 DOI: 10.3389/fimmu.2014.00499

Abstract

Nearly one quarter of the world's population is infected with helminth parasites. A common feature of helminth infections is the manifestation of a type 2 immune response, characterized by T helper 2 (Th2) cells that mediate anti-helminth immunity. In addition, recent literature describes a close association between type 2 immune responses and wound repair, suggesting that a Th2 response may concurrently mediate repair of parasite-induced damage. The molecular mechanisms that govern Th2 responses are poorly understood, although it is clear that dendritic cells (DCs), which are the most efficient antigen-presenting cells in the immune system, play a central role. Here, we review the molecular mechanisms by which DCs polarize Th2 cells, examining both helminth antigens and helminth-mediated tissue damage as Th2-inducing triggers. Finally, we discuss the implication of these findings in the context of metabolic disorders, as recent literature indicates that various aspects of the Th2-associated inflammatory response contribute to metabolic homeostasis.

Keywords: Th2 cells; antigen-presenting cells; dendritic cells; helminth; insulin resistance; metabolic diseases; obesity; type 2 inflammation

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