Display options
Cite
Landwehr-Kenzel S, Henneke P. Interaction of Streptococcus agalactiae and Cellular Innate Immunity in Colonization and Disease. Front Immunol. 2014;5:519doi: 10.3389/fimmu.2014.00519.
Landwehr-Kenzel, S., & Henneke, P. (2014). Interaction of Streptococcus agalactiae and Cellular Innate Immunity in Colonization and Disease. Frontiers in immunology, 5519. https://doi.org/10.3389/fimmu.2014.00519
Landwehr-Kenzel, Sybille, and Henneke, Philipp. "Interaction of Streptococcus agalactiae and Cellular Innate Immunity in Colonization and Disease." Frontiers in immunology vol. 5 (2014): 519. doi: https://doi.org/10.3389/fimmu.2014.00519
Landwehr-Kenzel S, Henneke P. Interaction of Streptococcus agalactiae and Cellular Innate Immunity in Colonization and Disease. Front Immunol. 2014 Oct 29;5:519. doi: 10.3389/fimmu.2014.00519. eCollection 2014. PMID: 25400631; PMCID: PMC4212683.
Copy Download .nbib Format: NLM
Share it on

Front Immunol. 2014 Oct 29;5:519. doi: 10.3389/fimmu.2014.00519. eCollection 2014.

Interaction of Streptococcus agalactiae and Cellular Innate Immunity in Colonization and Disease.

Frontiers in immunology

Sybille Landwehr-Kenzel, Philipp Henneke

Affiliations

  1. Berlin-Brandenburg Center for Regenerative Therapies, Charité University Medicine Berlin , Berlin , Germany ; Berlin-Brandenburg School for Regenerative Therapies, Charité University Medicine Berlin , Berlin , Germany ; Department of Pediatric Pulmonology and Immunology, Charité University Medicine Berlin , Berlin , Germany.
  2. Center for Pediatrics and Adolescent Medicine, University Medical Center Freiburg , Freiburg , Germany ; Center for Chronic Immunodeficiency, University Medical Center Freiburg , Freiburg , Germany.

PMID: 25400631 PMCID: PMC4212683 DOI: 10.3389/fimmu.2014.00519

Abstract

Streptococcus agalactiae (Group B streptococcus, GBS) is highly adapted to humans, where it is a normal constituent of the intestinal and vaginal flora. Yet, GBS has highly invasive potential and causes excessive inflammation, sepsis, and death at the beginning of life, in the elderly and in diabetic patients. Thus, GBS is a model pathobiont that thrives in the healthy host, but has not lost its potential virulence during coevolution with mankind. It remains incompletely understood how the innate immune system contains GBS in the natural niches, the intestinal and genital tracts, and which molecular events underlie breakdown of mucocutaneous resistance. Newborn infants between days 7 and 90 of life are at risk of a particularly striking sepsis manifestation (late-onset disease), where the transition from colonization to invasion and dissemination, and thus from health to severe sepsis is typically fulminant and not predictable. The great majority of late-onset sepsis cases are caused by one clone, GBS ST17, which expresses HvgA as a signature virulence factor and adhesin. In mice, HvgA promotes the crossing of both the mucosal and the blood-brain barrier. Expression levels of HvgA and other GBS virulence factors, such as pili and toxins, are regulated by the upstream two-component control system CovR/S. This in turn is modulated by acidic epithelial pH, high glucose levels, and during the passage through the mouse intestine. After invasion, GBS has the ability to subvert innate immunity by mechanisms like glycerinaldehyde-3-phosphate-dehydrogenase-dependent induction of IL-10 and β-protein binding to the inhibitory phagocyte receptors sialic acid binding immunoglobulin-like lectin 5 and 14. On the host side, sensing of GBS nucleic acids and lipopeptides by both Toll-like receptors and the inflammasome appears to be critical for host resistance against GBS. Yet, comprehensive models on the interplay between GBS and human immune cells at the colonizing site are just emerging.

Keywords: S. agalactiae; cellular innate immunity; colonization; intestinal microbiota; invasion; sepsis

References

  1. Clin Immunol. 2009 Nov;133(2):228-37 - PubMed
  2. J Bacteriol. 2009 Sep;191(17):5387-97 - PubMed
  3. J Immunol. 2004 May 15;172(10):6324-9 - PubMed
  4. Am J Gastroenterol. 1987 Dec;82(12):1322-5 - PubMed
  5. Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10278-83 - PubMed
  6. J Infect Dis. 2014 Jul 15;210(2):265-73 - PubMed
  7. Nat Rev Immunol. 2010 Jun;10(6):415-26 - PubMed
  8. Immunology. 1998 Jan;93(1):86-95 - PubMed
  9. PLoS One. 2013;8(1):e53876 - PubMed
  10. J Biol Chem. 2013 Dec 13;288(50):35982-96 - PubMed
  11. Mol Microbiol. 2007 Feb;63(3):754-67 - PubMed
  12. Pediatr Res. 2002 Mar;51(3):304-9 - PubMed
  13. Pediatrics. 2006 Aug;118(2):511-21 - PubMed
  14. J Exp Med. 1993 Feb 1;177(2):547-50 - PubMed
  15. Arch Dis Child Fetal Neonatal Ed. 1998 Jan;78(1):F46-50 - PubMed
  16. Nat Commun. 2012;3:1120 - PubMed
  17. J Exp Med. 2010 Oct 25;207(11):2313-22 - PubMed
  18. PLoS Biol. 2007 Jul;5(7):e177 - PubMed
  19. J Exp Med. 1992 Aug 1;176(2):415-26 - PubMed
  20. Infection. 1987;15(5):332-6 - PubMed
  21. Infect Immun. 1997 Dec;65(12):5216-21 - PubMed
  22. J Mol Med (Berl). 2014 Sep;92(9):951-9 - PubMed
  23. Mol Microbiol. 1991 Apr;5(4):843-9 - PubMed
  24. Proc Natl Acad Sci U S A. 1989 Jun;86(12):4731-5 - PubMed
  25. Trends Microbiol. 2005 Feb;13(2):52-6 - PubMed
  26. J Infect Dis. 2012 Sep 15;206(6):924-31 - PubMed
  27. Infect Immun. 2005 Jun;73(6):3342-50 - PubMed
  28. Curr Opin Microbiol. 2012 Feb;15(1):44-9 - PubMed
  29. Pediatr Crit Care Med. 2005 May;6(3 Suppl):S45-9 - PubMed
  30. J Leukoc Biol. 2004 Jun;75(6):982-94 - PubMed
  31. Am J Obstet Gynecol. 1981 Mar 1;139(5):512-5 - PubMed
  32. Pediatrics. 2011 May;127(5):817-26 - PubMed
  33. Zentralbl Bakteriol Mikrobiol Hyg A. 1987 Oct;266(3-4):330-7 - PubMed
  34. J Immunol. 2009 Dec 1;183(11):7150-60 - PubMed
  35. Microbes Infect. 2007 May;9(6):714-20 - PubMed
  36. Mol Microbiol. 2003 Jun;48(5):1417-25 - PubMed
  37. PLoS Pathog. 2009 May;5(5):e1000422 - PubMed
  38. Pediatr Infect Dis J. 2006 Oct;25(10):945-8 - PubMed
  39. Mol Microbiol. 2010 Jul;77(2):431-43 - PubMed
  40. Vaccine. 2008 Jan 24;26(4):502-8 - PubMed
  41. Microsc Res Tech. 2001 Aug 15;54(4):254-9 - PubMed
  42. Clin Dev Immunol. 2013;2013:526860 - PubMed
  43. Medicine (Baltimore). 2010 Nov;89(6):403-25 - PubMed
  44. J Immunol. 2012 Nov 1;189(9):4582-91 - PubMed
  45. Proc Natl Acad Sci U S A. 1987 Oct;84(20):7208-12 - PubMed
  46. Microb Pathog. 2008 Jan;44(1):84-8 - PubMed
  47. Science. 2005 Jul 1;309(5731):105 - PubMed
  48. J Clin Microbiol. 2009 Apr;47(4):1143-8 - PubMed
  49. Cell. 2010 Mar 19;140(6):859-70 - PubMed
  50. BMC Pediatr. 2011 Apr 14;11:29 - PubMed
  51. Pediatr Res. 1999 May;45(5 Pt 1):626-34 - PubMed
  52. J Immunol. 2012 Feb 15;188(4):1953-60 - PubMed
  53. Can J Microbiol. 2003 May;49(5):350-6 - PubMed
  54. J Clin Microbiol. 2003 Jun;41(6):2530-6 - PubMed
  55. PLoS One. 2012;7(1):e29963 - PubMed
  56. Annu Rev Nutr. 2002;22:283-307 - PubMed
  57. Mol Microbiol. 2009 Mar;71(6):1477-95 - PubMed
  58. Annu Rev Immunol. 2001;19:683-765 - PubMed
  59. Cell Host Microbe. 2008 Dec 11;4(6):543-54 - PubMed
  60. J Endotoxin Res. 2002;8(6):459-63 - PubMed
  61. Infect Dis Clin North Am. 1999 Sep;13(3):711-33, viii - PubMed
  62. Early Hum Dev. 2014 Mar;90 Suppl 1:S57-9 - PubMed
  63. Clin Microbiol Rev. 2011 Jul;24(3):490-7 - PubMed
  64. J Exp Med. 2012 Feb 13;209(2):235-41 - PubMed
  65. Int Immunol. 2014 Oct;26(10):563-73 - PubMed
  66. Pediatrics. 2010 Sep;126(3):443-56 - PubMed
  67. Int J Infect Dis. 2009 Nov;13(6):679-84 - PubMed
  68. Pediatrics. 2014 May;133(5):e1388-91 - PubMed
  69. J Immunol. 2004 Sep 1;173(5):3392-7 - PubMed
  70. Int Arch Allergy Appl Immunol. 1987;84(1):32-9 - PubMed
  71. EMBO Rep. 2011 Jan;12(1):71-6 - PubMed
  72. J Bacteriol. 2012 May;194(10):2479-90 - PubMed
  73. Infect Immun. 1991 Aug;59(8):2638-44 - PubMed
  74. J Immunol. 2007 Mar 1;178(5):2667-78 - PubMed
  75. Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10452-9 - PubMed
  76. J Exp Med. 2002 Oct 21;196(8):1017-24 - PubMed
  77. Immunity. 2006 Dec;25(6):941-52 - PubMed
  78. Microbiology. 2006 Apr;152(Pt 4):1029-40 - PubMed
  79. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3074-9 - PubMed
  80. Mol Microbiol. 2006 Nov;62(4):941-57 - PubMed
  81. Curr Opin Microbiol. 2006 Apr;9(2):143-52 - PubMed
  82. Infect Immun. 1996 Sep;64(9):3818-26 - PubMed
  83. Blood. 1994 Feb 15;83(4):1086-92 - PubMed
  84. Infect Immun. 2004 Apr;72(4):2416-9 - PubMed
  85. J Exp Med. 2007 May 14;204(5):1107-18 - PubMed
  86. Microbes Infect. 2006 Jun;8(7):1714-22 - PubMed
  87. Immunity. 2005 Apr;22(4):467-77 - PubMed
  88. PLoS Pathog. 2012;8(7):e1002812 - PubMed
  89. J Infect Dis. 1999 Jun;179(6):1410-5 - PubMed
  90. Trends Immunol. 2009 Dec;30(12):585-91 - PubMed
  91. Mol Microbiol. 2006 Jul;61(1):126-41 - PubMed
  92. J Clin Invest. 2003 Sep;112(5):736-44 - PubMed
  93. Infect Immun. 2014 Mar;82(3):1007-16 - PubMed
  94. J Immunol. 2004 Apr 15;172(8):4733-43 - PubMed
  95. Adv Exp Med Biol. 2000;478:77-93 - PubMed
  96. Pediatrics. 2006 Jun;117(6):e1139-45 - PubMed
  97. Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4131-6 - PubMed
  98. J Bacteriol. 2005 Feb;187(3):1105-13 - PubMed
  99. J Biol Chem. 2010 Jun 18;285(25):19593-604 - PubMed
  100. Respir Res. 2011 Dec 05;12:155 - PubMed
  101. Proc Natl Acad Sci U S A. 2004 Oct 5;101(40):14491-6 - PubMed
  102. J Leukoc Biol. 2006 Sep;80(3):492-9 - PubMed
  103. Science. 2005 Jun 10;308(5728):1635-8 - PubMed
  104. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15451-5 - PubMed
  105. Gastroenterology. 2011 Jan;140(1):242-53 - PubMed
  106. Am J Obstet Gynecol. 1996 Apr;174(4):1354-60 - PubMed
  107. Clin Infect Dis. 2009 Nov 1;49(9):1393-6 - PubMed
  108. Lancet. 2010 Oct 9;376(9748):1272 - PubMed
  109. J Exp Med. 1993 Apr 1;177(4):1205-8 - PubMed
  110. Eur J Clin Microbiol Infect Dis. 2004 Nov;23(11):818-24 - PubMed
  111. Antonie Van Leeuwenhoek. 2012 Mar;101(3):677-82 - PubMed
  112. Infect Immun. 1999 Feb;67(2):871-8 - PubMed
  113. J Leukoc Biol. 1994 Jun;55(6):711-8 - PubMed
  114. Infect Immun. 1992 Dec;60(12):4989-94 - PubMed
  115. Gastroenterol Clin North Am. 2005 Sep;34(3):401-12, vii-viii - PubMed
  116. Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10060-4 - PubMed
  117. J Infect Dis. 2005 Apr 15;191(8):1287-91 - PubMed
  118. Ann Intern Med. 1995 Sep 15;123(6):415-20 - PubMed
  119. J Infect Dis. 2009 Jan 1;199(1):108-15 - PubMed
  120. Mol Microbiol. 2002 Oct;46(2):557-69 - PubMed
  121. J Infect Dis. 2006 Jan 15;193(2):241-50 - PubMed
  122. Immunology. 2007 Jan;120(1):19-27 - PubMed
  123. Clin Exp Immunol. 2004 Nov;138(2):290-8 - PubMed
  124. Microbes Infect. 2006 Apr;8(5):1227-43 - PubMed
  125. J Autoimmun. 2003 Nov;21(3):277-81 - PubMed
  126. Mol Microbiol. 2004 Dec;54(5):1250-68 - PubMed
  127. PLoS One. 2013 Aug 30;8(8):e73465 - PubMed
  128. Infect Immun. 2003 Nov;71(11):6344-53 - PubMed
  129. J Pediatr. 1993 Aug;123(2):292-300 - PubMed
  130. Cell Microbiol. 2013 Jul;15(7):1154-67 - PubMed
  131. J Immunol. 2004 Mar 1;172(5):3111-8 - PubMed
  132. J Perinat Med. 2011 Jul;39(4):417-22 - PubMed
  133. Immunol Rev. 2008 Oct;225:114-27 - PubMed
  134. J Infect Dis. 1983 Apr;147(4):776 - PubMed
  135. J Immunol. 2008 May 1;180(9):6149-58 - PubMed
  136. Appl Environ Microbiol. 1998 Oct;64(10):3854-9 - PubMed
  137. Pediatr Res. 1993 Jan;33(1):27-31 - PubMed
  138. Am J Gastroenterol. 2011 Aug;106(8):1544-55 - PubMed
  139. J Immunol. 2008 May 1;180(9):5771-7 - PubMed
  140. Infect Immun. 2000 Sep;68(9):5018-25 - PubMed
  141. J Infect Dis. 2002 Jan 15;185(2):196-203 - PubMed
  142. Cell Host Microbe. 2011 May 19;9(5):355-61 - PubMed
  143. Trends Biochem Sci. 2005 Mar;30(3):142-50 - PubMed
  144. Mol Med. 2011;17(11-12):1146-56 - PubMed
  145. J Bacteriol. 2001 Nov;183(21):6324-34 - PubMed
  146. Front Cell Infect Microbiol. 2012 Oct 16;2:94 - PubMed
  147. Curr Top Microbiol Immunol. 2005;291:11-28 - PubMed
  148. Microbiology. 2007 Dec;153(Pt 12):4039-49 - PubMed
  149. PLoS Pathog. 2011 Nov;7(11):e1002363 - PubMed
  150. J Immunol. 2006 Mar 1;176(5):3181-8 - PubMed
  151. N Engl J Med. 2009 Nov 19;361(21):2033-45 - PubMed
  152. J Exp Med. 1987 Mar 1;165(3):720-32 - PubMed
  153. J Pediatr. 1973 Dec;83(6):919-25 - PubMed
  154. Vet Microbiol. 2003 Oct 8;96(1):103-13 - PubMed
  155. Infect Immun. 2001 Aug;69(8):5098-106 - PubMed
  156. Pediatrics. 2002 Jul;110(1 Pt 1):36-41 - PubMed
  157. Oncoimmunology. 2013 Mar 1;2(3):e23141 - PubMed
  158. J Biol Chem. 2003 Oct 3;278(40):38167-73 - PubMed
  159. Nat Immunol. 2009 Jun;10(6):587-94 - PubMed
  160. PLoS Pathog. 2013 Feb;9(2):e1003179 - PubMed
  161. Nature. 2011 Jan 27;469(7331):543-7 - PubMed
  162. Arch Dis Child Fetal Neonatal Ed. 1995 May;72(3):F172-5 - PubMed
  163. Clin Perinatol. 2014 Jun;41(2):423-35 - PubMed
  164. JAMA. 2008 May 7;299(17):2056-65 - PubMed
  165. Nature. 2012 Sep 13;489(7415):231-41 - PubMed
  166. Clin Infect Dis. 2014 May;58(9):1211-8 - PubMed
  167. J Immunol. 1999 Sep 1;163(5):2777-82 - PubMed
  168. PLoS One. 2011 Apr 15;6(4):e18747 - PubMed
  169. J Immunol. 2012 Jan 15;188(2):774-80 - PubMed
  170. Blood. 2007 Apr 1;109 (7):2887-93 - PubMed
  171. Clin Infect Dis. 2009 Jul 1;49(1):85-92 - PubMed
  172. J Immunol. 2013 Nov 1;191(9):4759-68 - PubMed
  173. Emerg Infect Dis. 2008 Oct;14(10):1647-9 - PubMed
  174. J Immunol. 2007 Feb 1;178(3):1379-87 - PubMed
  175. J Biol Chem. 2014 May 16;289(20):13701-5 - PubMed
  176. CMAJ. 2013 Mar 19;185(5):385-94 - PubMed
  177. Infect Immun. 1996 Jul;64(7):2850-2 - PubMed
  178. Med Microbiol Immunol. 1994 Nov;183(5):239-56 - PubMed
  179. Pediatr Infect Dis J. 2004 Feb;23(2):172-3 - PubMed
  180. PLoS Pathog. 2014 Jan;10(1):e1003846 - PubMed

Publication Types