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Oncol Lett. 2015 Jan;9(1):3-8. doi: 10.3892/ol.2014.2696. Epub 2014 Nov 10.

Diagnostic and prognostic serum marker of cholangiocarcinoma (Review).

Oncology letters

Xiaojun Zeng, Hualin Tao

Affiliations

  1. Department of Laboratory Medicine, Luzhou Medical College, Luzhou, Sichuan 646000, P.R. China.
  2. Department of Laboratory Medicine, Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000, P.R. China.

PMID: 25435926 PMCID: PMC4247112 DOI: 10.3892/ol.2014.2696

Abstract

Cholangiocarcinoma (CCA) is a fatal disease that is typically diagnosed late and treated ineffectively. As the morbidity and mortality rates for CCA rise markedly, patietns with CCA currently have a poor prognosis. However, if it were possible to diagnose CCA early while effective treat methods are available, CCA patients would achieve a better quality of life. Therefore, preventing the process of CCA in the early stages is an urgent problem to solve. An accurate, quick and safe method to diagnose early-stage CCA is required. The present review discusses the risk factors, status of research and certain serum markers of CCA. The sensitivity and specificity of these markers differ from each other. To explore the more accurate serum markers may be a novel direction and method for the diagnosis of CCA in laboratory medicine in the future.

Keywords: cholangiocarcinoma; diagnostic; prognostic; serum marker

References

  1. Exp Biol Med (Maywood). 2012 Oct;237(10):1142-9 - PubMed
  2. Surg Endosc. 2013 Nov;27(11):4210-6 - PubMed
  3. Southeast Asian J Trop Med Public Health. 2009 Jul;40(4):701-12 - PubMed
  4. Clin Res Hepatol Gastroenterol. 2011 Oct;35(10):644-9 - PubMed
  5. Tumour Biol. 2013 Apr;34(2):695-704 - PubMed
  6. Chin Med J (Engl). 2003 Nov;116(11):1678-82 - PubMed
  7. Mol Cancer. 2010 Jan 24;9:13 - PubMed
  8. Clin Chim Acta. 2013 Oct 21;425:236-41 - PubMed
  9. World J Gastroenterol. 2010 Oct 7;16(37):4697-703 - PubMed
  10. Clin Exp Metastasis. 2013 Oct;30(7):877-90 - PubMed
  11. World J Gastrointest Oncol. 2013 Jul 15;5(7):132-8 - PubMed
  12. Am J Pathol. 2012 Jan;180(1):123-30 - PubMed
  13. Eur J Gastroenterol Hepatol. 2013 Dec;25(12):1408-14 - PubMed
  14. Dig Liver Dis. 2013 Apr;45(4):316-22 - PubMed
  15. Cancer Biomark. 2012;12(2):81-95 - PubMed
  16. J Cancer Res Clin Oncol. 2012 Aug;138(8):1311-20 - PubMed
  17. J Hepatol. 2013 Dec;59(6):1278-84 - PubMed
  18. Clin Cancer Res. 2007 Dec 15;13(24):7370-9 - PubMed
  19. Int J Cancer. 2012 Aug 15;131(4):E416-24 - PubMed
  20. Ann Surg Oncol. 2012 Aug;19(8):2506-14 - PubMed
  21. Eur J Cancer. 2009 Jan;45(1):33-47 - PubMed
  22. Asian Pac J Cancer Prev. 2012;13 Suppl:131-6 - PubMed
  23. J Viral Hepat. 2010 Oct;17(10):742-8 - PubMed
  24. J Hepatol. 2012 Oct;57(4):813-20 - PubMed
  25. Eur J Med Res. 2010 Aug 20;15(8):357-61 - PubMed
  26. Hepatogastroenterology. 2008 Nov-Dec;55(88):2000-4 - PubMed
  27. J Hepatobiliary Pancreat Sci. 2013 Mar;20(3):389-95 - PubMed
  28. J Proteome Res. 2008 Nov;7(11):4670-7 - PubMed
  29. Asian Pac J Cancer Prev. 2012;13 Suppl:107-14 - PubMed
  30. Ann Surg Oncol. 2013 Dec;20 Suppl 3:S616-24 - PubMed
  31. Am Surg. 2010 Nov;76(11):1210-3 - PubMed
  32. Int J Hepatol. 2011;2011:873548 - PubMed
  33. Tumour Biol. 2014 Feb;35(2):1029-39 - PubMed
  34. Int J Cancer. 2013 Oct 15;133(8):1867-75 - PubMed
  35. Parasitol Int. 2012 Mar;61(1):151-4 - PubMed
  36. Int J Parasitol. 2010 Aug 15;40(10):1203-12 - PubMed
  37. World J Gastrointest Pathophysiol. 2010 Apr 15;1(1):12-22 - PubMed
  38. Front Med China. 2010 Dec;4(4):457-62 - PubMed
  39. Int J Cancer. 2011 Dec 1;129(11):2543-52 - PubMed
  40. Eur J Cancer Care (Engl). 2009 Nov;18(6):625-35 - PubMed
  41. Oncologist. 2012;17(1):72-9 - PubMed
  42. Parasitol Int. 2012 Mar;61(1):145-50 - PubMed
  43. Clin Gastroenterol Hepatol. 2011 May;9(5):434-9.e1 - PubMed
  44. BMC Gastroenterol. 2009 Apr 30;9:30 - PubMed
  45. Biochem Biophys Res Commun. 1978 Feb 14;80(3):623-30 - PubMed
  46. J Clin Pathol. 2004 Nov;57(11):1156-9 - PubMed
  47. World J Gastroenterol. 2009 Aug 21;15(31):3916-9 - PubMed
  48. Amino Acids. 2011 Apr;40(4):1053-63 - PubMed
  49. Dig Dis Sci. 2011 Aug;56(8):2491-6 - PubMed
  50. J Biomed Biotechnol. 2010;2010:437143 - PubMed
  51. World J Gastroenterol. 2013 May 7;19(17 ):2621-8 - PubMed
  52. Clin Exp Immunol. 2010 Sep;161(3):471-9 - PubMed
  53. BMC Cancer. 2008 Aug 16;8:241 - PubMed
  54. Biochem J. 1996 Aug 15;318 ( Pt 1):1-14 - PubMed
  55. Acta Pharmacol Sin. 2004 May;25(5):672-7 - PubMed
  56. Urology. 2012 Oct;80(4):952.e1-7 - PubMed
  57. J Gastroenterol Hepatol. 2012 Oct;27(10):1561-8 - PubMed
  58. Cell Biochem Biophys. 2013;67(3):1033-9 - PubMed
  59. Int J Oncol. 2011 Oct;39(4):873-81 - PubMed
  60. World J Gastroenterol. 2012 Jun 14;18(22):2805-12 - PubMed
  61. Cancer Sci. 2013 Oct;104(10):1278-84 - PubMed
  62. Indian J Clin Biochem. 2012 Jan;27(1):90-3 - PubMed
  63. Anticancer Res. 2005 May-Jun;25(3A):1507-15 - PubMed
  64. Dig Liver Dis. 2009 Aug;41(8):605-8 - PubMed
  65. Asian Pac J Cancer Prev. 2012;13 Suppl:41-5 - PubMed
  66. Gut. 2001 Jun;48(6):816-20 - PubMed
  67. Semin Liver Dis. 2011 Feb;31(1):49-60 - PubMed
  68. World J Gastroenterol. 2005 Sep 21;11(35):5450-4 - PubMed
  69. Br J Cancer. 2003 Sep 15;89(6):1028-30 - PubMed
  70. Cancer Epidemiol Biomarkers Prev. 2009 Apr;18(4):1127-33 - PubMed
  71. Gut. 2012 Dec;61(12 ):1657-69 - PubMed
  72. Asian Pac J Cancer Prev. 2011;12(6):1503-10 - PubMed
  73. Cancer. 2011 Aug 1;117(15):3393-403 - PubMed
  74. PLoS One. 2012;7(2):e31868 - PubMed
  75. Gut. 2002 Nov;51 Suppl 6:VI1-9 - PubMed

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