Horm Mol Biol Clin Investig. 2012 Dec;12(2):391-400. doi: 10.1515/hmbci-2012-0026.
Circulating 5α-dihydrotestosterone, abdominal obesity and adipocyte characteristics in women.
Hormone molecular biology and clinical investigation
Julie A Côté, Julie Lessard, Jacques Mailloux, Philippe Laberge, Caroline Rhéaume, André Tchernof
PMID: 25436698
DOI: 10.1515/hmbci-2012-0026
Abstract
UNLABELLED: Abstract Background: The association between circulating androgen levels and fat distribution in women has been widely inconsistent among existing studies.
OBJECTIVE: We sought to investigate the relation between plasma adrenal and gonadal androgen levels and body fat distribution, as well as abdominal adipocyte characteristics.
METHODS: Paired omental and subcutaneous adipose tissue samples were surgically obtained from 60 women (age, 47±5 years; body mass index, 26±5 kg/m2) undergoing gynecological surgery. Body composition and fat distribution were measured by dual-energy X-ray absorptiometry and computed tomography, respectively. Adipocyte diameter, basal lipolysis, and heparin-releasable lipoprotein lipase activity were measured. Steroids were quantified using high-performance gas chromatography and mass spectrometry.
RESULTS: Significant negative associations were found between plasma dihydrotestosterone (DHT) levels and total adiposity (body mass index, r=-0.35, p<0.05; fat mass, r=-0.31, p<0.05) as well as computed tomography assessments of abdominal adiposity (r=-0.30, p<0.05 and r=-0.44, p<0.005 for subcutaneous and visceral adipose tissue area, respectively). The association between DHT levels and visceral adipose tissue area was independent of total body fat mass. A significant negative association was also observed between plasma DHT and omental adipocyte diameter (r=-0.27, p<0.05). When expressed as the omental/subcutaneous ratio, heparin-releasable lipoprotein lipase activity was negatively and significantly related to plasma DHT, androstenedione, and dehydroepiandrosterone (DHEA) levels.
CONCLUSION: Abdominally obese women with large, metabolically active omental adipocytes appear to be characterized by reduced endogenous levels of DHT. The assumption that high androgen levels are associated with an android body fat distribution pattern in women should be critically re-examined.
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