Future Cardiol. 2014 Nov;10(6):789-800. doi: 10.2217/fca.14.64.

MiRNAs as potential molecular targets in heart failure.

Future cardiology

Michael G Katz, Anthony S Fargnoli, Richard D Williams, Andrew P Kendle, Nury M Steuerwald, Charles R Bridges

PMID: 25495820 DOI: 10.2217/fca.14.64

Abstract

Pathogenesis of heart diseases is associated with an altered expression profile of hundreds of genes. miRNAs are a newly identified layer of gene regulation operating at the post-transcriptional level by pairing to complementary base sequences in target mRNAs. Genetic data have identified the roles of miRNAs in basic pathological processes associated with heart failure: apoptosis, fibrosis, myocardial hypertrophy and cardiac remodeling. Many reports demonstrated that aberrantly expressed miRNAs and their modulation have effects on cardiac insufficiency. Here, we overview the advances in miRNAs as potential targets in the modulation of the heart failure phenotype. miRNA-based therapy holds great promise as a future strategy for treating heart diseases and identifying emerging signaling pathways responsible for the progression of heart failure.

Keywords: apoptosis; cardiac remodeling; fibrosis; heart failure; microRNAs; myocardial hypertrophy

Substances

• MicroRNAs

MeSH terms

• Heart Failure / etiology
• Heart Failure / pathology
• Humans
• MicroRNAs / physiology
• Ventricular Remodeling / physiology

Publication Types

• Journal Article
• Research Support, N.I.H., Extramural
• Research Support, Non-U.S. Gov't
• Review

Grant support

• 2R01 HL083078-05/HL/NHLBI NIH HHS/United States