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Kukreti V, Daoud H, Bola SS, et al. Early critical care course in children after liver transplant. Crit Care Res Pract. 2014;2014:725748doi: 10.1155/2014/725748.
Kukreti, V., Daoud, H., Bola, S. S., Singh, R. N., Atkison, P., & Kornecki, A. (2014). Early critical care course in children after liver transplant. Critical care research and practice, 2014725748. https://doi.org/10.1155/2014/725748
Kukreti, Vinay, et al. "Early critical care course in children after liver transplant." Critical care research and practice vol. 2014 (2014): 725748. doi: https://doi.org/10.1155/2014/725748
Kukreti V, Daoud H, Bola SS, Singh RN, Atkison P, Kornecki A. Early critical care course in children after liver transplant. Crit Care Res Pract. 2014;2014:725748. doi: 10.1155/2014/725748. Epub 2014 Sep 25. PMID: 25328695; PMCID: PMC4190826.
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Crit Care Res Pract. 2014;2014:725748. doi: 10.1155/2014/725748. Epub 2014 Sep 25.

Early critical care course in children after liver transplant.

Critical care research and practice

Vinay Kukreti, Hani Daoud, Sundeep S Bola, Ram N Singh, Paul Atkison, Alik Kornecki

Affiliations

  1. Department of Pediatric Critical Care Medicine, Children's Hospital, London Health Sciences Centre, University of Western Ontario, 800 Commissioners Road East, P.O. Box 5010, London, ON, Canada N6A 5W9.
  2. Division of Respiratory Medicine, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON, Canada M5G 1X8.
  3. Department of Pediatrics, Children's Hospital, London Health Sciences Centre, University of Western Ontario, 800 Commissioners Road East, P.O. Box 5010, London, ON, Canada N6A 5W9.
  4. Department of Pediatric Critical Care Medicine, Children's Hospital, London Health Sciences Centre, University of Western Ontario, 800 Commissioners Road East, P.O. Box 5010, London, ON, Canada N6A 5W9 ; Children's Health Research Institute, 800 Commissioners Road East, P.O. Box 5010, London, ON, Canada N6A 5W9.

PMID: 25328695 PMCID: PMC4190826 DOI: 10.1155/2014/725748

Abstract

Objective. To review the critical care course of children receiving orthotopic liver transplantation (OLT). Methods. A retrospective chart review of patients admitted to the pediatric critical care following OLT performed in our center between 1988 and 2011. Results. A total of 149 transplants in 145 patients with a median age of 2.7 (IQR 0.9-7) years were analyzed. Mortality in the first 28 days was 8%. The median length of stay (LOS) was 7 (4.0-12.0) days. The median length of mechanical ventilation (MV) was 3 (1.0-6.2) days. Open abdomen, age, and oxygenation index on the 2nd day predicted LOS. Open abdomen, age, amount of blood transfused during surgery, and PRISM III predicted length of MV. 28% of patients had infection and 24% developed acute rejection. In recent group (2000-2011) OLT was performed in younger patients; the risk of infection and acute rejection was reduced and patients required longer LOS and MV compared with old group (1988-1999). Conclusion. The postoperative course of children after OLT is associated with multiple complications. In recent years OLT was performed in younger children; living donors were more common; the rate of postoperative infection and suspected rejection was reduced significantly; however patients required longer MV and LOS in the PCCU.

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