Display options
Cite
Yu FJ, Zheng JJ, Dong PH, et al. Long non-coding RNAs and hepatocellular carcinoma. Mol Clin Oncol. 2014;3(1):13-17doi: 10.3892/mco.2014.429.
Yu, F. J., Zheng, J. J., Dong, P. H., & Fan, X. M. (2015). Long non-coding RNAs and hepatocellular carcinoma. Molecular and clinical oncology, 3(1), 13-17. https://doi.org/10.3892/mco.2014.429
Yu, Fu-Jun, et al. "Long non-coding RNAs and hepatocellular carcinoma." Molecular and clinical oncology vol. 3,1 (2015): 13-17. doi: https://doi.org/10.3892/mco.2014.429
Yu FJ, Zheng JJ, Dong PH, Fan XM. Long non-coding RNAs and hepatocellular carcinoma. Mol Clin Oncol. 2015 Jan;3(1):13-17. doi: 10.3892/mco.2014.429. Epub 2014 Sep 25. PMID: 25469263; PMCID: PMC4251171.
Copy Download .nbib Format: NLM
Share it on

Mol Clin Oncol. 2015 Jan;3(1):13-17. doi: 10.3892/mco.2014.429. Epub 2014 Sep 25.

Long non-coding RNAs and hepatocellular carcinoma.

Molecular and clinical oncology

Fu-Jun Yu, Jian-Jian Zheng, Pei-Hong Dong, Xiao-Ming Fan

Affiliations

  1. Department of Gastroenterology, Jinshan Hospital of Fudan University, Jinshan, Shanghai 201508.
  2. Wenzhou Key Laboratory of Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.
  3. Wenzhou Key Laboratory of Surgery, Department of Infectious Diseases, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.

PMID: 25469263 PMCID: PMC4251171 DOI: 10.3892/mco.2014.429

Abstract

Recent advances in next-generation sequencing technology in transcriptome analysis have helped identify numerous non-coding RNAs. The long non-coding RNA (lncRNA) is commonly defined as an RNA molecule with a length of 200 bp-100 kbp that lacks protein-coding potential. LncRNAs play a critical role in the regulation of gene expression, including chromatin modification, transcription and post-transcriptional processing. It has been confirmed that dysregulation of lncRNAs is associated with a number of human diseases, particularly tumors. In this study, we focused on the most extensively investigated lncRNAs in hepatocellular carcinoma (HCC). The biological functions and molecular mechanisms of the majority of lncRNAs have yet to be investigated. The improved knowledge on lncRNAs in HCC may help identify lncRNAs that may be used as novel prognostic markers and therapeutic targets.

Keywords: H19; HOX antisense intergenic RNA; downregulated expression by HBx; hepatocellular carcinoma; high expression in HCC; highly upregulated in liver cancer; long non-coding RNA; maternally expressed gene 3; metastasis associated lung adenocarcinoma transcript 1; microvascular invasion in HCC

References

  1. Nucleic Acids Res. 2014 Feb;42(3):1772-83 - PubMed
  2. PLoS One. 2012;7(4):e35145 - PubMed
  3. Biomed Res Int. 2013;2013:136106 - PubMed
  4. Gastroenterology. 2007 Jan;132(1):330-42 - PubMed
  5. MBio. 2013 Jan 29;4(1):e00596-12 - PubMed
  6. Med Oncol. 2012 Sep;29(3):1810-6 - PubMed
  7. FEBS J. 2013 Apr;280(7):1709-16 - PubMed
  8. BMC Genomics. 2013 Nov 14;14:789 - PubMed
  9. Hepatology. 2011 Nov;54(5):1679-89 - PubMed
  10. Hepatology. 2013 May;57(5):1882-92 - PubMed
  11. Clin Transl Oncol. 2014 Apr;16(4):410-7 - PubMed
  12. Curr Drug Targets. 2012 Dec;13(13):1616-21 - PubMed
  13. Cancer Res. 1999 Dec 1;59(23):5975-9 - PubMed
  14. Cancer Lett. 2013 Oct 10;339(2):159-66 - PubMed
  15. RNA Biol. 2012 Jun;9(6):703-19 - PubMed
  16. Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12417-22 - PubMed
  17. Mol Cell. 2014 Feb 20;53(4):549-61 - PubMed
  18. Hepatogastroenterology. 2013 May;60(123):549-52 - PubMed
  19. Oncol Rep. 2013 Mar;29(3):946-50 - PubMed
  20. Nucleic Acids Res. 2010 Sep;38(16):5366-83 - PubMed
  21. Hepatology. 2013 Mar;57(3):1285-6 - PubMed
  22. FEBS J. 2014 Jan;281(1):88-103 - PubMed
  23. J Int Med Res. 2011;39(6):2119-28 - PubMed
  24. J Biol Chem. 2012 Jul 27;287(31):26302-11 - PubMed
  25. Mol Cell Biochem. 2010 Nov;344(1-2):195-202 - PubMed
  26. Front Mol Neurosci. 2013 Dec 30;6:53 - PubMed
  27. BMC Cell Biol. 2013 May 27;14 :26 - PubMed
  28. Int J Mol Sci. 2013 Feb 21;14(2):4298-316 - PubMed
  29. Folia Histochem Cytobiol. 2012 Jul 05;50(2):171-9 - PubMed
  30. J Mol Biol. 2013 Oct 9;425(19):3723-30 - PubMed
  31. Cell Metab. 2014 Jan 7;19(1):135-45 - PubMed
  32. PLoS One. 2012;7(11):e49462 - PubMed
  33. Oncogene. 2011 Nov 24;30(47):4750-6 - PubMed
  34. J Exp Clin Cancer Res. 2011 Dec 01;30:110 - PubMed
  35. Mol Cell. 2014 Feb 6;53(3):393-406 - PubMed
  36. Breast Cancer Res Treat. 2013 Dec;142(3):529-36 - PubMed
  37. Neuro Oncol. 2013 Dec;15(12):1595-603 - PubMed
  38. Am J Transplant. 2013 Mar;13(3):729-37 - PubMed
  39. Biochem Pharmacol. 2013 Jun 15;85(12):1761-9 - PubMed
  40. Tumour Biol. 2013 Apr;34(2):613-20 - PubMed
  41. Neoplasma. 2013;60(5):486-92 - PubMed
  42. Int J Biochem Cell Biol. 2013 Aug;45(8):1895-910 - PubMed
  43. Ann Surg Oncol. 2011 May;18(5):1243-50 - PubMed
  44. J Mol Endocrinol. 2012 Apr 02;48(3):R45-53 - PubMed
  45. Int J Mol Sci. 2013 Jul 31;14(8):16010-39 - PubMed
  46. Mol Cell. 2012 Aug 24;47(4):648-55 - PubMed
  47. Carcinogenesis. 2013 Mar;34(3):577-86 - PubMed
  48. Int J Mol Med. 2013 Jul;32(1):17-24 - PubMed
  49. Mol Carcinog. 2013 Nov;52(11):908-15 - PubMed
  50. Hepatology. 2012 Dec;56(6):2231-41 - PubMed
  51. Nucleic Acids Res. 2012 Aug;40(14):6391-400 - PubMed
  52. Nature. 2014 Jan 30;505(7485):635-40 - PubMed
  53. Cancer Lett. 2014 Mar 1;344(1):20-7 - PubMed
  54. PLoS One. 2007 Sep 05;2(9):e845 - PubMed
  55. Mol Biosyst. 2013 Mar;9(3):407-11 - PubMed
  56. Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20693-8 - PubMed
  57. J Neurooncol. 2013 Mar;112(1):1-8 - PubMed
  58. Mol Biol Rep. 2014 Jun;41(6):3915-23 - PubMed
  59. Crit Rev Eukaryot Gene Expr. 2012;22(1):1-15 - PubMed
  60. J Neurosurg. 1999 Aug;91(2):308-12 - PubMed
  61. Eur J Gastroenterol Hepatol. 2009 Jun;21(6):688-92 - PubMed
  62. PLoS One. 2011;6(10):e25915 - PubMed
  63. Cell. 2007 Jun 29;129(7):1311-23 - PubMed
  64. Int J Biochem Cell Biol. 2014 Sep;54:338-49 - PubMed
  65. Oncol Rep. 2014 Jan;31(1):358-64 - PubMed
  66. Mol Cell. 2013 Apr 25;50(2):212-22 - PubMed
  67. FEBS Lett. 2013 Oct 1;587(19):3175-81 - PubMed
  68. Int J Mol Med. 2010 May;25(5):801-6 - PubMed

Publication Types