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Meddeb S, Rhim MS, Kouira M, et al. Ewing's Sarcoma: An Uncommon Breast Tumor. Clin Pract. 2014;4(2):659doi: 10.4081/cp.2014.659.
Meddeb, S., Rhim, M. S., Kouira, M., Mestiri, S., Bibi, M., & Yacoubi, M. T. (2014). Ewing's Sarcoma: An Uncommon Breast Tumor. Clinics and practice, 4(2), 659. https://doi.org/10.4081/cp.2014.659
Meddeb, Sawsen, et al. "Ewing's Sarcoma: An Uncommon Breast Tumor." Clinics and practice vol. 4,2 (2014): 659. doi: https://doi.org/10.4081/cp.2014.659
Meddeb S, Rhim MS, Kouira M, Mestiri S, Bibi M, Yacoubi MT. Ewing's Sarcoma: An Uncommon Breast Tumor. Clin Pract. 2014 Oct 03;4(2):659. doi: 10.4081/cp.2014.659. eCollection 2014 Jun 18. PMID: 25332765; PMCID: PMC4202187.
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Clin Pract. 2014 Oct 03;4(2):659. doi: 10.4081/cp.2014.659. eCollection 2014 Jun 18.

Ewing's Sarcoma: An Uncommon Breast Tumor.

Clinics and practice

Sawsen Meddeb, Mohamed Salah Rhim, Mouna Kouira, Sarra Mestiri, Mohamed Bibi, Mohamed Tahar Yacoubi

Affiliations

  1. Department of Gynecology and Obstetrics, Farhat Hached University Hospital , Sousse, Tunisia ; Research Laboratory in Quality of Maternal Health Care in Tunisia , Sousse, Tunisia.
  2. Department of Gynecology and Obstetrics, Farhat Hached University Hospital , Sousse, Tunisia.
  3. Department of Pathology, Farhat Hached University Hospital , Sousse, Tunisia.

PMID: 25332765 PMCID: PMC4202187 DOI: 10.4081/cp.2014.659

Abstract

Ewing's sarcoma/primitive neuroectodermal tumors (EWS/PNET) are rare malignant and aggressive tumors, usually seen in the trunk and lower limbs of children and young adults. They are uncommon in the breast. We report a case of a 43-year-old woman who developed a painless breast mass. An initial core needle biopsy concluded to a fibrocystic dystrophy contrasting with a rapidly growing mass; thus a large lumpectomy was done. Diagnosis of primary PNET of the breast was established, based on both histopathological examination and immunohistochemical findings. Surgical margins were positive, therefore, left modified radical mastectomy with axillary lymph nodes dissection was performed. The patient was given 6 cycles of adjuvant chemotherapy containing cyclophosphamide, adriamycin and vincristine. Twenty months later, she is in life without recurrence or metastasis. EWS/PNET may impose a diagnostic challenge. Indeed, mammography and ultrasonography features are non specific. The histopathological pattern is variable depending on the degree of neuroectodermal differentiation. Immuno-phenotyping is necessary and genetic study is the only confirmatory tool of diagnosis showing a characteristic cytogenetic anomaly; t (11; 22) translocation.

Keywords: Ewing’s sarcoma; Primitive neuroectodermal tumor; breast

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