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Regensburger M, Huttner HB, Doerfler A, et al. Propofol-related urine discoloration in a patient with fatal atypical intracerebral hemorrhage treated with hypothermia. Springerplus. 2014;3:551doi: 10.1186/2193-1801-3-551.
Regensburger, M., Huttner, H. B., Doerfler, A., Schwab, S., & Staykov, D. (2014). Propofol-related urine discoloration in a patient with fatal atypical intracerebral hemorrhage treated with hypothermia. SpringerPlus, 3551. https://doi.org/10.1186/2193-1801-3-551
Regensburger, Martin, et al. "Propofol-related urine discoloration in a patient with fatal atypical intracerebral hemorrhage treated with hypothermia." SpringerPlus vol. 3 (2014): 551. doi: https://doi.org/10.1186/2193-1801-3-551
Regensburger M, Huttner HB, Doerfler A, Schwab S, Staykov D. Propofol-related urine discoloration in a patient with fatal atypical intracerebral hemorrhage treated with hypothermia. Springerplus. 2014 Sep 23;3:551. doi: 10.1186/2193-1801-3-551. eCollection 2014. PMID: 25332856; PMCID: PMC4192142.
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Springerplus. 2014 Sep 23;3:551. doi: 10.1186/2193-1801-3-551. eCollection 2014.

Propofol-related urine discoloration in a patient with fatal atypical intracerebral hemorrhage treated with hypothermia.

SpringerPlus

Martin Regensburger, Hagen B Huttner, Arnd Doerfler, Stefan Schwab, Dimitre Staykov

Affiliations

  1. Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany ; Division of Molecular Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany.
  2. Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany.
  3. Department of Neuroradiology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany.

PMID: 25332856 PMCID: PMC4192142 DOI: 10.1186/2193-1801-3-551

Abstract

INTRODUCTION: Mild therapeutic hypothermia is an increasingly recognised treatment option to reduce perihemorrhagic edema in severe intracerebral hemorrhage.

CASE DESCRIPTION: We report the case of a 77-year old woman with atypical intracerebral hemorrhage that was treated with mild hypothermia in addition to osmotic therapy. The patient's urine subsequently showed a green discoloration. Urine discoloration was completely reversible upon discontinuation of propofol.

DISCUSSION AND EVALUATION: Propofol-related urine discoloration may have been provoked by hypothermia. Due to the benign nature of this side effect, propofol should be stopped and gastrointestinal function should be supported.

CONCLUSION: More studies are needed to show a causal role of hypothermia and related decreased enzymatic function.

Keywords: Enterohepatic circulation; Hypothermia; Intracerebral hemorrhage; Liver enzyme function; Urine discoloration

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